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CHP2 calcineurin like EF-hand protein 2 [ Homo sapiens (human) ]

Gene ID: 63928, updated on 24-Nov-2020

Summary

Official Symbol
CHP2provided by HGNC
Official Full Name
calcineurin like EF-hand protein 2provided by HGNC
Primary source
HGNC:HGNC:24927
See related
Ensembl:ENSG00000166869
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013]
Expression
Biased expression in duodenum (RPKM 110.6), small intestine (RPKM 92.6) and 2 other tissues See more
Orthologs

Genomic context

See CHP2 in Genome Data Viewer
Location:
16p12.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (23755026..23758935)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (23765948..23770272)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene dynactin subunit 5 Neighboring gene polo like kinase 1 Neighboring gene endoplasmic reticulum to nucleus signaling 2 Neighboring gene CRISPRi-validated cis-regulatory element chr16.1865 Neighboring gene CRISPRi-validated cis-regulatory element chr16.1866

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calcineurin B homologous protein 2
Names
hepatocellular carcinoma antigen gene 520
hepatocellular carcinoma-associated antigen 520

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022097.4NP_071380.1  calcineurin B homologous protein 2

    See identical proteins and their annotated locations for NP_071380.1

    Status: REVIEWED

    Source sequence(s)
    AF146019, BF197519
    Consensus CDS
    CCDS10617.1
    UniProtKB/Swiss-Prot
    O43745
    Related
    ENSP00000300113.2, ENST00000300113.3
    Conserved Domains (1) summary
    COG5126
    Location:16179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    23755026..23758935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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