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DUSP21 dual specificity phosphatase 21 [ Homo sapiens (human) ]

Gene ID: 63904, updated on 17-Jun-2019

Summary

Official Symbol
DUSP21provided by HGNC
Official Full Name
dual specificity phosphatase 21provided by HGNC
Primary source
HGNC:HGNC:20476
See related
Ensembl:ENSG00000189037 MIM:300678
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LMWDSP21
Summary
This gene encodes a member of the dual specificity phosphatase family, specifically the low molecular weight dual specificity phosphatase family. The encoded protein localizes to both the cytoplasm and the nucleus and functions to remove phosphate groups from phosphotyrosine and phosphothreonine residues.[provided by RefSeq, Mar 2009]
Orthologs

Genomic context

See DUSP21 in Genome Data Viewer
Location:
Xp11.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (44844021..44844888)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (44703249..44704134)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA pseudogene 61 Neighboring gene RNA, 7SL, cytoplasmic 291, pseudogene Neighboring gene uncharacterized LOC105373190 Neighboring gene lysine demethylase 6A

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC149878

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MAP kinase tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
inactivation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity protein phosphatase 21
Names
BJ-HCC-26 tumor antigen
LMW-DSP21
low molecular weight dual specificity phosphatase 21
NP_071359.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013231.1 RefSeqGene

    Range
    5001..5886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022076.4NP_071359.3  dual specificity protein phosphatase 21

    See identical proteins and their annotated locations for NP_071359.3

    Status: REVIEWED

    Source sequence(s)
    AA813372, AF533018
    Consensus CDS
    CCDS14264.1
    UniProtKB/Swiss-Prot
    Q9H596
    Related
    ENSP00000343244.4, ENST00000339042.5
    Conserved Domains (1) summary
    cd00127
    Location:23157
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    44844021..44844888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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