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A4galt alpha 1,4-galactosyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 63888, updated on 17-Aug-2024

Summary

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Official Symbol
A4galtprovided by RGD
Official Full Name
alpha 1,4-galactosyltransferaseprovided by RGD
Primary source
RGD:621583
See related
EnsemblRapid:ENSRNOG00000009736 AllianceGenome:RGD:621583
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gb3
Summary
Enables galactosyltransferase activity. Predicted to be involved in glycosphingolipid biosynthetic process. Predicted to act upstream of or within globoside biosynthetic process and plasma membrane organization. Predicted to be located in membrane. Orthologous to human A4GALT (alpha 1,4-galactosyltransferase (P blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 68.9), Heart (RPKM 15.6) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q34
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (116248571..116272917, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (114368525..114392872, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (124085832..124110440, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 38 Neighboring gene cytochrome b5 reductase 3 Neighboring gene ADP-ribosylation factor GTPase activating protein 3 Neighboring gene protein kinase C and casein kinase substrate in neurons 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The P blood group system: biochemical, serological, and clinical aspects. Spitalnik PF, et al. Transfus Med Rev, 1995 Apr. PMID 7795329
  2. Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipid synthesis, predicts a family of alpha 1, 4-glycosyltransferases conserved in plants, insects, and mammals. Keusch JJ, et al. J Biol Chem, 2000 Aug 18. PMID 10854428
  3. Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids. Kojima Y, et al. J Biol Chem, 2000 May 19. PMID 10748143
  4. Cloning and expression of the histo-blood group Pk UDP-galactose: Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. Molecular genetic basis of the p phenotype. Steffensen R, et al. J Biol Chem, 2000 Jun 2. PMID 10747952
  5. Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins. Okuda T, et al. J Biol Chem, 2006 Apr 14. PMID 16476743

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables galactosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lactosylceramide 4-alpha-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables toxic substance binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within globoside biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within plasma membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lactosylceramide 4-alpha-galactosyltransferase
Names
Gb3 synthase
UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase
alpha 1,4-galactosyltransferase (P blood group)
alpha-1,4-N-acetylglucosaminyltransferase
alpha4Gal-T1
globotriaosylceramide synthase
NP_071576.1
XP_006242179.1
XP_006242180.1
XP_017450570.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022240.2 → NP_071576.1  lactosylceramide 4-alpha-galactosyltransferase

    See identical proteins and their annotated locations for NP_071576.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097323
    UniProtKB/Swiss-Prot
    Q4QR98, Q9JI93
    UniProtKB/TrEMBL
    A6HT88
    Conserved Domains (2) summary
    pfam04488
    Location:98 → 221
    Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
    pfam04572
    Location:234 → 356
    Gb3_synth; Alpha 1,4-glycosyltransferase conserved region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    116248571..116272917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242117.5 → XP_006242179.1  lactosylceramide 4-alpha-galactosyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006242179.1

    UniProtKB/Swiss-Prot
    Q4QR98, Q9JI93
    UniProtKB/TrEMBL
    A6HT88
    Conserved Domains (2) summary
    pfam04488
    Location:98 → 221
    Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
    pfam04572
    Location:234 → 356
    Gb3_synth; Alpha 1,4-glycosyltransferase conserved region

  2. XM_006242118.5 → XP_006242180.1  lactosylceramide 4-alpha-galactosyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006242180.1

    UniProtKB/Swiss-Prot
    Q4QR98, Q9JI93
    UniProtKB/TrEMBL
    A6HT88
    Related
    ENSRNOP00000112147.1, ENSRNOT00000122895.1
    Conserved Domains (2) summary
    pfam04488
    Location:98 → 221
    Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
    pfam04572
    Location:234 → 356
    Gb3_synth; Alpha 1,4-glycosyltransferase conserved region

  3. XM_017595081.3 → XP_017450570.1  lactosylceramide 4-alpha-galactosyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q4QR98, Q9JI93
    UniProtKB/TrEMBL
    A6HT88
    Related
    ENSRNOP00000064362.1, ENSRNOT00000012914.7
    Conserved Domains (2) summary
    pfam04488
    Location:98 → 221
    Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
    pfam04572
    Location:234 → 356
    Gb3_synth; Alpha 1,4-glycosyltransferase conserved region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JI93.1 GenPept UniProtKB/Swiss-Prot:Q9JI93

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