U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PKNOX2 PBX/knotted 1 homeobox 2 [ Homo sapiens (human) ]

Gene ID: 63876, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
PKNOX2provided by HGNC
Official Full Name
PBX/knotted 1 homeobox 2provided by HGNC
Primary source
HGNC:HGNC:16714
See related
Ensembl:ENSG00000165495 MIM:613066; AllianceGenome:HGNC:16714
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PREP2
Summary
Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009]
Expression
Broad expression in thyroid (RPKM 4.8), ovary (RPKM 4.1) and 21 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PKNOX2 in Genome Data Viewer
Location:
11q24.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (125164751..125433389)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (125193419..125462086)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (125034647..125303285)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene keratin 18 pseudogene 59 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125011687-125012243 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4039 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125048979-125049726 Neighboring gene PKNOX2 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125049727-125050473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125084643-125085174 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:125094169-125094781 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:125098532-125099526 Neighboring gene PKNOX2 antisense RNA 1 Neighboring gene RNA, U6 small nuclear 321, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125181994-125182578 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125211245-125211994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125219321-125219863 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:125220519-125221182 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:125221183-125221844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125239164-125240045 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125241808-125242687 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:125278650-125279849 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125296399-125296900 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125298605-125299508 Neighboring gene Sharpr-MPRA regulatory region 8813 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:125314964-125315827 Neighboring gene Sharpr-MPRA regulatory region 13231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5697 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:125364213-125364716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125365219-125365722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125365723-125366224 Neighboring gene fasciculation and elongation protein zeta 1 Neighboring gene putative uncharacterized protein MGC39545 Neighboring gene CRISPRi-validated cis-regulatory element chr11.5907 Neighboring gene Sharpr-MPRA regulatory region 4861 Neighboring gene CRISPRi-validated cis-regulatory element chr11.5909 Neighboring gene CRISPRi-validated cis-regulatory element chr11.5910 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:125439037-125439538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5698 Neighboring gene STT3A antisense RNA 1 Neighboring gene RNA, U6 small nuclear 1156, pseudogene Neighboring gene EI24 autophagy associated transmembrane protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification and characterization of human PKNOX2, a novel homeobox-containing gene. Imoto I, et al. Biochem Biophys Res Commun, 2001 Sep 14. PMID 11549286
  2. PKNOX2 expression and regulation in the bone marrow mesenchymal stem cells of Fanconi anemia patients and healthy donors. Cagnan I, et al. Mol Biol Rep, 2019 Feb. PMID 30515693
  3. The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women. Chen X, et al. PLoS One, 2011 Jan 27. PMID 21298047, Free PMC Article
  4. PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis. Chen L, et al. Signal Transduct Target Ther, 2024 Apr 22. PMID 38644381, Free PMC Article
  5. Characterization of PREP2, a paralog of PREP1, which defines a novel sub-family of the MEINOX TALE homeodomain transcription factors. Fognani C, et al. Nucleic Acids Res, 2002 May 1. PMID 11972344, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis.
    Title: PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis.
  2. PKNOX2 is a tumor suppressor in gastric cancer by activation of IGFBP5 and p53 signaling pathways
    Title: PKNOX2 suppresses gastric cancer through the transcriptional activation of IGFBP5 and p53.
  3. PKNOX2 was significantly downregulated in Fanconi anemia cells compared to donors.
    Title: PKNOX2 expression and regulation in the bone marrow mesenchymal stem cells of Fanconi anemia patients and healthy donors.
  4. We identified four new loci (PKNOX2, MYH13, PHF2, and GPC6) associated with formal thought disorder in schizophrenia.
    Title: PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies.
  5. Using data from several genomewide case-control studies, we identified a strong and significant association signal with a novel gene, PKNOX2, on chromosome 11 with the composite phenotype in European-origin women
    Title: The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.
  6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  9. This novel PKNOX-related protein may interact with PBX proteins and play a role in tissue-specific regulation of transcription.
    Title: Identification and characterization of human PKNOX2, a novel homeobox-containing gene.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.
EBI GWAS Catalog
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
EBI GWAS Catalog
Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.
EBI GWAS Catalog
Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.
EBI GWAS Catalog
Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies.
EBI GWAS Catalog
The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ13074

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables actin monomer binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
homeobox protein PKNOX2
Names
PBX/knotted homeobox 2
homeobox protein PREP-2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382323.2 → NP_001369252.1  homeobox protein PKNOX2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069
    Consensus CDS
    CCDS41730.1
    UniProtKB/Swiss-Prot
    B7Z5I5, F5GZ15, Q63HL6, Q86XD1, Q96KN3
    UniProtKB/TrEMBL
    B7Z3G7, B7Z9N6
    Related
    ENSP00000298282.8, ENST00000298282.14
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  2. NM_001382324.1 → NP_001369253.1  homeobox protein PKNOX2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069
    Consensus CDS
    CCDS41730.1
    UniProtKB/Swiss-Prot
    B7Z5I5, F5GZ15, Q63HL6, Q86XD1, Q96KN3
    UniProtKB/TrEMBL
    B7Z3G7, B7Z9N6
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  3. NM_001382325.1 → NP_001369254.1  homeobox protein PKNOX2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069
    Consensus CDS
    CCDS41730.1
    UniProtKB/Swiss-Prot
    B7Z5I5, F5GZ15, Q63HL6, Q86XD1, Q96KN3
    UniProtKB/TrEMBL
    B7Z3G7, B7Z9N6
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  4. NM_001382326.1 → NP_001369255.1  homeobox protein PKNOX2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069
    Consensus CDS
    CCDS41730.1
    UniProtKB/Swiss-Prot
    B7Z5I5, F5GZ15, Q63HL6, Q86XD1, Q96KN3
    UniProtKB/TrEMBL
    B7Z3G7, B7Z9N6
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  5. NM_001382327.1 → NP_001369256.1  homeobox protein PKNOX2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069
    Consensus CDS
    CCDS41730.1
    UniProtKB/Swiss-Prot
    B7Z5I5, F5GZ15, Q63HL6, Q86XD1, Q96KN3
    UniProtKB/TrEMBL
    B7Z3G7, B7Z9N6
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  6. NM_001382328.1 → NP_001369257.1  homeobox protein PKNOX2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069
    Consensus CDS
    CCDS41730.1
    UniProtKB/Swiss-Prot
    B7Z5I5, F5GZ15, Q63HL6, Q86XD1, Q96KN3
    UniProtKB/TrEMBL
    B7Z3G7, B7Z9N6
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  7. NM_001382329.1 → NP_001369258.1  homeobox protein PKNOX2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 8-11, encodes isoform b.
    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069
    UniProtKB/TrEMBL
    B7Z3G7, B7Z9N6, B7ZAF3
    Conserved Domains (2) summary
    pfam05920
    Location:277 → 316
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:67 → 152
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  8. NM_001382330.1 → NP_001369259.1  homeobox protein PKNOX2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 7 and 9-11, encodes isoform b.
    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069
    UniProtKB/TrEMBL
    B7Z3G7, B7Z9N6, B7ZAF3
    Conserved Domains (2) summary
    pfam05920
    Location:277 → 316
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:67 → 152
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  9. NM_001382331.1 → NP_001369260.1  homeobox protein PKNOX2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 7, 8, 10, and 11, encodes isoform b.
    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069
    UniProtKB/TrEMBL
    B7Z3G7, B7Z9N6, B7ZAF3
    Conserved Domains (2) summary
    pfam05920
    Location:277 → 316
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:67 → 152
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  10. NM_001382332.1 → NP_001369261.1  homeobox protein PKNOX2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 7-9 and 11, encodes isoform b.
    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069
    UniProtKB/TrEMBL
    B7Z3G7, B7Z9N6, B7ZAF3
    Conserved Domains (2) summary
    pfam05920
    Location:277 → 316
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:67 → 152
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  11. NM_001382333.1 → NP_001369262.1  homeobox protein PKNOX2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 7-10, encodes isoform b.
    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069
    UniProtKB/TrEMBL
    B7Z3G7, B7Z9N6, B7ZAF3
    Conserved Domains (2) summary
    pfam05920
    Location:277 → 316
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:67 → 152
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  12. NM_001382334.1 → NP_001369263.1  homeobox protein PKNOX2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variant 13, encodes isoform c.
    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069
    Conserved Domains (3) summary
    pfam05920
    Location:194 → 229
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  13. NM_001382335.1 → NP_001369264.1  homeobox protein PKNOX2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variant 12, encodes isoform c.
    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069
    Conserved Domains (3) summary
    pfam05920
    Location:194 → 229
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  14. NM_001382336.1 → NP_001369265.1  homeobox protein PKNOX2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 15 and 16, encodes isoform d.
    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069
    Conserved Domains (2) summary
    pfam05920
    Location:165 → 200
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:67 → 152
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  15. NM_001382337.1 → NP_001369266.1  homeobox protein PKNOX2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variants 14 and 16, encodes isoform d.
    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069
    Conserved Domains (2) summary
    pfam05920
    Location:165 → 200
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:67 → 152
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  16. NM_001382338.1 → NP_001369267.1  homeobox protein PKNOX2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variants 14 and 15, encodes isoform d.
    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069
    Conserved Domains (2) summary
    pfam05920
    Location:165 → 200
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:67 → 152
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  17. NM_001382339.1 → NP_001369268.1  homeobox protein PKNOX2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069
    UniProtKB/TrEMBL
    B7Z3G7, B7Z9N6
    Conserved Domains (3) summary
    pfam05920
    Location:302 → 341
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  18. NM_001382340.1 → NP_001369269.1  homeobox protein PKNOX2 isoform f

    Status: VALIDATED

    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069
    UniProtKB/TrEMBL
    B7Z3G7, B7Z9N6
    Conserved Domains (2) summary
    pfam05920
    Location:242 → 281
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:32 → 117
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  19. NM_001382341.1 → NP_001369270.1  homeobox protein PKNOX2 isoform g

    Status: VALIDATED

    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069
    UniProtKB/TrEMBL
    B7Z3G7, B7Z9N6
    Conserved Domains (3) summary
    pfam05920
    Location:230 → 269
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

RNA

  1. NR_168076.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069

  2. NR_168077.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069

  3. NR_168078.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069

  4. NR_168079.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069

  5. NR_168080.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069

  6. NR_168081.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069

  7. NR_168082.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069

  8. NR_168083.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069

  9. NR_168084.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000708, AP001007, AP003061, AP003069

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    125164751..125433389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    125193419..125462086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022062.3: Suppressed sequence

    Description
    NM_022062.3: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96KN3.2 GenPept UniProtKB/Swiss-Prot:Q96KN3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools