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SERPINB4 serpin family B member 4 [ Homo sapiens (human) ]

Gene ID: 6318, updated on 1-Jun-2020

Summary

Official Symbol
SERPINB4provided by HGNC
Official Full Name
serpin family B member 4provided by HGNC
Primary source
HGNC:HGNC:10570
See related
Ensembl:ENSG00000206073 MIM:600518
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PI11; SCCA1; SCCA2; LEUPIN; SCCA-2
Summary
The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. [provided by RefSeq, Jan 2017]
Expression
Biased expression in esophagus (RPKM 63.1), urinary bladder (RPKM 11.6) and 1 other tissue See more
Orthologs

Genomic context

See SERPINB4 in Genome Data Viewer
Location:
18q21.33
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (63637259..63644310, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (61304493..61311502, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene serpin family B member 12 Neighboring gene serpin family B member 13 Neighboring gene serpin family B member 3 Neighboring gene serpin family B member 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
serine-type endopeptidase inhibitor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
protection from natural killer cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of proteolysis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serpin B4
Names
SCCA2/SCCA1 fusion protein
peptidase inhibitor 11
protease inhibitor (leucine-serpin)
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 4
serpin peptidase inhibitor, clade B (ovalbumin), member 4
squamous cell carcinoma antigen 1
squamous cell carcinoma antigen 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053001.1 RefSeqGene

    Range
    5064..12061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002974.4NP_002965.1  serpin B4 isoform 1

    See identical proteins and their annotated locations for NP_002965.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC017401, BU676816
    Consensus CDS
    CCDS11986.1
    UniProtKB/Swiss-Prot
    P48594
    Related
    ENSP00000343445.5, ENST00000341074.10
    Conserved Domains (1) summary
    cl00137
    Location:4390
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
  2. NM_175041.2NP_778206.1  serpin B4 isoform 2

    See identical proteins and their annotated locations for NP_778206.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB046400, AK292212, BU676816
    UniProtKB/Swiss-Prot
    P48594
    UniProtKB/TrEMBL
    Q9BYF7
    Related
    ENSP00000398645.1, ENST00000413673.5
    Conserved Domains (1) summary
    cl00137
    Location:4369
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    63637259..63644310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526138.1XP_011524440.1  serpin B4 isoform X1

    See identical proteins and their annotated locations for XP_011524440.1

    UniProtKB/Swiss-Prot
    P48594
    Conserved Domains (1) summary
    cl00137
    Location:4390
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
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