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S100A12 S100 calcium binding protein A12 [ Homo sapiens (human) ]

Gene ID: 6283, updated on 5-Jul-2025
Official Symbol
S100A12provided by HGNC
Official Full Name
S100 calcium binding protein A12provided by HGNC
Primary source
HGNC:HGNC:10489
See related
Ensembl:ENSG00000163221 MIM:603112; AllianceGenome:HGNC:10489
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p6; CAGC; CGRP; MRP6; CAAF1; MRP-6; ENRAGE
Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity. [provided by RefSeq, Nov 2014]
Expression
Restricted expression toward bone marrow (RPKM 747.5) See more
Orthologs
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See S100A12 in Genome Data Viewer
Location:
1q21.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153373711..153375621, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152510935..152512845, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153346187..153348097, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 160, pseudogene Neighboring gene peptidoglycan recognition protein 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1741 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1743 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1340 Neighboring gene S100 calcium binding protein A9 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:153352860-153353030 Neighboring gene lysosomal protein transmembrane 4 beta pseudogene 1 Neighboring gene MPRA-validated peak414 silencer Neighboring gene S100 calcium binding protein A8 Neighboring gene S100 calcium binding protein A15A (pseudogene)

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RAGE receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RAGE receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RAGE receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RAGE receptor binding TAS
Traceable Author Statement
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
enables calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables copper ion binding TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to bacterium TAS
Traceable Author Statement
more info
PubMed 
involved_in defense response to fungus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to fungus IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to fungus TAS
Traceable Author Statement
more info
PubMed 
involved_in endothelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in killing of cells of another organism IDA
Inferred from Direct Assay
more info
PubMed 
involved_in killing of cells of another organism IEA
Inferred from Electronic Annotation
more info
 
involved_in mast cell activation TAS
Traceable Author Statement
more info
PubMed 
involved_in monocyte chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in neutrophil chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of MAP kinase activity TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 
Preferred Names
protein S100-A12
Names
EN-RAGE
calcitermin
calcium-binding protein in amniotic fluid 1
calgranulin C
extracellular newly identified RAGE-binding protein
migration inhibitory factor-related protein 6
neutrophil S100 protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005621.2NP_005612.1  protein S100-A12

    See identical proteins and their annotated locations for NP_005612.1

    Status: REVIEWED

    Source sequence(s)
    AL591704, D83664
    Consensus CDS
    CCDS1037.1
    UniProtKB/Swiss-Prot
    P80511, P83219, Q5SY66, Q7M4R1
    Related
    ENSP00000357726.3, ENST00000368737.5
    Conserved Domains (1) summary
    cd05030
    Location:289
    calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    153373711..153375621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    152510935..152512845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)