Format

Send to:

Choose Destination

S100A12 S100 calcium binding protein A12 [ Homo sapiens (human) ]

Gene ID: 6283, updated on 1-Jun-2020

Summary

Official Symbol
S100A12provided by HGNC
Official Full Name
S100 calcium binding protein A12provided by HGNC
Primary source
HGNC:HGNC:10489
See related
Ensembl:ENSG00000163221 MIM:603112
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p6; CAGC; CGRP; MRP6; CAAF1; MRP-6; ENRAGE
Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity. [provided by RefSeq, Nov 2014]
Expression
Restricted expression toward bone marrow (RPKM 747.5) See more
Orthologs

Genomic context

See S100A12 in Genome Data Viewer
Location:
1q21.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (153373711..153375621, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153346184..153348075, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene peptidoglycan recognition protein 4 Neighboring gene RNA, U6 small nuclear 160, pseudogene Neighboring gene S100 calcium binding protein A9 Neighboring gene lysosomal protein transmembrane 4 beta pseudogene 1 Neighboring gene S100 calcium binding protein A8 Neighboring gene S100 calcium binding protein A15A (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RAGE receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
RAGE receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
RAGE receptor binding TAS
Traceable Author Statement
more info
PubMed 
calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
copper ion binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein S100-A12
Names
EN-RAGE
calcitermin
calcium-binding protein in amniotic fluid 1
calgranulin C
extracellular newly identified RAGE-binding protein
migration inhibitory factor-related protein 6
neutrophil S100 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005621.2NP_005612.1  protein S100-A12

    See identical proteins and their annotated locations for NP_005612.1

    Status: REVIEWED

    Source sequence(s)
    AL591704, D83664
    Consensus CDS
    CCDS1037.1
    UniProtKB/Swiss-Prot
    P80511
    Related
    ENSP00000357726.3, ENST00000368737.5
    Conserved Domains (1) summary
    cd05030
    Location:289
    calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    153373711..153375621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center