S100A12 S100 calcium binding protein A12 [Homo sapiens (human)] - Gene

Summary

Official Symbol: S100A12provided by HGNC
Official Full Name: S100 calcium binding protein A12provided by HGNC
Primary source: HGNC:HGNC:10489
See related: Ensembl:ENSG00000163221 MIM:603112
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p6; CAGC; CGRP; MRP6; CAAF1; MRP-6; ENRAGE
Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity. [provided by RefSeq, Nov 2014]
Expression: Restricted expression toward bone marrow (RPKM 747.5) See more
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1q21.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109.20210514	current	GRCh38.p13 (GCF_000001405.39)	1	NC_000001.11 (153373711..153375621, complement)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (153346187..153348097, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impact of chorioamnionitis on maternal and fetal levels of proinflammatory S100A12.
Title: Impact of chorioamnionitis on maternal and fetal levels of proinflammatory S100A12.
Serum S100A12 levels are correlated with clinical severity in patients with dermatomyositis-associated interstitial lung disease.
Title: Serum S100A12 levels are correlated with clinical severity in patients with dermatomyositis-associated interstitial lung disease.
A single transcript for the prognosis of disease severity in COVID-19 patients.
Title: A single transcript for the prognosis of disease severity in COVID-19 patients.
Urine and serum S100A8/A9 and S100A12 associate with active lupus nephritis and may predict response to rituximab treatment.
Title: Urine and serum S100A8/A9 and S100A12 associate with active lupus nephritis and may predict response to rituximab treatment.
Evaluation of the S100 protein A12 as a biomarker of neonatal sepsis.
Title: Evaluation of the S100 protein A12 as a biomarker of neonatal sepsis.
S100A12 Expression Is Modulated During Monocyte Differentiation and Reflects Periodontitis Severity.
Title: S100A12 Expression Is Modulated During Monocyte Differentiation and Reflects Periodontitis Severity.
Epigenetic Regulation of S100A9 and S100A12 Expression in Monocyte-Macrophage System in Hyperglycemic Conditions.
Title: Epigenetic Regulation of S100A9 and S100A12 Expression in Monocyte-Macrophage System in Hyperglycemic Conditions.
Downregulation of S100 calcium binding protein A12 inhibits the growth of glioma cells.
Title: Downregulation of S100 calcium binding protein A12 inhibits the growth of glioma cells.
MiR-30a Regulates S100A12-induced Retinal Microglial Activation and Inflammation by Targeting NLRP3.
Title: MiR-30a Regulates S100A12-induced Retinal Microglial Activation and Inflammation by Targeting NLRP3.
S100A12 is a promising biomarker in papillary thyroid cancer.
Title: S100A12 is a promising biomarker in papillary thyroid cancer.

Submit: New GeneRIF Correction See all GeneRIFs (117)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

G54103 (e-PCR)
- UniSTS:109340

WI-17060 (e-PCR)
- UniSTS:63450

Homology

Homologs of the S100A12 gene: The S100A12 gene is conserved in chimpanzee, dog, and cow.
Orthologs from Annotation Pipeline: 102 organisms have orthologs with human gene S100A12
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RAGE receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RAGE receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables RAGE receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RAGE receptor binding	TAS Traceable Author Statement more info	PubMed
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables calcium ion binding	TAS Traceable Author Statement more info	PubMed
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables copper ion binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	TAS Traceable Author Statement more info	PubMed
involved_in defense response to fungus	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to fungus	TAS Traceable Author Statement more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	TAS Traceable Author Statement more info	PubMed
involved_in killing of cells of other organism	IDA Inferred from Direct Assay more info	PubMed
involved_in mast cell activation	TAS Traceable Author Statement more info	PubMed
involved_in monocyte chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in neutrophil chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAP kinase activity	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in xenobiotic metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	TAS Traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in secretory granule lumen	TAS Traceable Author Statement more info

General protein information

Go to the top of the page Help

Preferred Names: protein S100-A12

Names: EN-RAGE; calcitermin; calcium-binding protein in amniotic fluid 1; calgranulin C; extracellular newly identified RAGE-binding protein; migration inhibitory factor-related protein 6; neutrophil S100 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005621.2 → NP_005612.1 protein S100-A12

See identical proteins and their annotated locations for NP_005612.1

Status: REVIEWED

Source sequence(s)

AL591704, D83664

Consensus CDS

CCDS1037.1

UniProtKB/Swiss-Prot

P80511

Related

ENSP00000357726.3, ENST00000368737.5

Conserved Domains (1) summary

cd05030
Location:2 → 89

calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...