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RRAD RRAD, Ras related glycolysis inhibitor and calcium channel regulator [ Homo sapiens (human) ]

Gene ID: 6236, updated on 7-Dec-2018

Summary

Official Symbol
RRADprovided by HGNC
Official Full Name
RRAD, Ras related glycolysis inhibitor and calcium channel regulatorprovided by HGNC
Primary source
HGNC:HGNC:10446
See related
Ensembl:ENSG00000166592 MIM:179503
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAD; RAD1; REM3
Expression
Biased expression in heart (RPKM 57.6), esophagus (RPKM 28.6) and 11 other tissues See more
Orthologs

Genomic context

See RRAD in Genome Data Viewer
Location:
16q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (66921679..66925536, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (66955582..66959439, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984821 Neighboring gene VISTA enhancer hs1760 Neighboring gene cadherin 16 Neighboring gene cytosolic iron-sulfur assembly component 2B Neighboring gene carboxylesterase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of high voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
GTP-binding protein RAD
Names
RAS (RAD and GEM) like GTP binding 3
RRAD, Ras related glycolysis inihibitor and calcium channel regulator
Ras-related associated with diabetes
ras associated with diabetes

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128850.1NP_001122322.1  GTP-binding protein RAD

    See identical proteins and their annotated locations for NP_001122322.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BC057815, BP257026, N93445
    Consensus CDS
    CCDS10824.1
    UniProtKB/Swiss-Prot
    P55042
    UniProtKB/TrEMBL
    A0A024R6X0
    Related
    ENSP00000388744.1, ENST00000420652.5
    Conserved Domains (2) summary
    cd04148
    Location:92308
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
    smart00173
    Location:92252
    RAS; Ras subfamily of RAS small GTPases
  2. NM_004165.3NP_004156.1  GTP-binding protein RAD

    See identical proteins and their annotated locations for NP_004156.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BP257026, L24564, N93445
    Consensus CDS
    CCDS10824.1
    UniProtKB/Swiss-Prot
    P55042
    UniProtKB/TrEMBL
    A0A024R6X0
    Related
    ENSP00000299759.6, ENST00000299759.10
    Conserved Domains (2) summary
    cd04148
    Location:92308
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
    smart00173
    Location:92252
    RAS; Ras subfamily of RAS small GTPases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    66921679..66925536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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