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RPS29 ribosomal protein S29 [ Homo sapiens (human) ]

Gene ID: 6235, updated on 3-May-2020

Summary

Official Symbol
RPS29provided by HGNC
Official Full Name
ribosomal protein S29provided by HGNC
Primary source
HGNC:HGNC:10419
See related
Ensembl:ENSG00000213741 MIM:603633
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S29; uS14; DBA13
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit and a member of the S14P family of ribosomal proteins. The protein, which contains a C2-C2 zinc finger-like domain that can bind to zinc, can enhance the tumor suppressor activity of Ras-related protein 1A (KREV1). It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]
Expression
Ubiquitous expression in colon (RPKM 132.6), ovary (RPKM 125.8) and 25 other tissues See more
Orthologs

Genomic context

See RPS29 in Genome Data Viewer
Location:
14q21.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (49570988..49598710, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (50043390..50053134, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984701 Neighboring gene RNA, 5S ribosomal pseudogene 384 Neighboring gene ribosomal protein L32 pseudogene 29 Neighboring gene uncharacterized LOC107987206 Neighboring gene RNA component of signal recognition particle 7SL1 Neighboring gene ras homolog family member Q pseudogene 1 Neighboring gene leucine rich repeat protein 1 Neighboring gene ribosomal protein L36a pseudogene 42 Neighboring gene ribosomal protein L36a like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Diamond-Blackfan anemia 13
MedGen: C4014641 OMIM: 615909 GeneReviews: Diamond-Blackfan Anemia
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural constituent of ribosome HDA PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
cytoplasmic translation IDA
Inferred from Direct Assay
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation IC
Inferred by Curator
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
40S ribosomal protein S29
Names
small ribosomal subunit protein uS14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050638.2 RefSeqGene

    Range
    17295..32723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001030001.4NP_001025172.1  40S ribosomal protein S29 isoform 2

    See identical proteins and their annotated locations for NP_001025172.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) utilizes an alternate 3'-terminal exon, compared to variant 1, resulting in a longer isoform (2) with a unique C-terminus.
    Source sequence(s)
    AL139099, BC015974, BU942244
    Consensus CDS
    CCDS32072.1
    UniProtKB/Swiss-Prot
    P62273
    Related
    ENSP00000379339.3, ENST00000396020.7
    Conserved Domains (1) summary
    PTZ00218
    Location:154
    PTZ00218; 40S ribosomal protein S29; Provisional
  2. NM_001032.5NP_001023.1  40S ribosomal protein S29 isoform 1

    See identical proteins and their annotated locations for NP_001023.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant transcript and encodes isoform 1.
    Source sequence(s)
    BC035313, BU942244
    Consensus CDS
    CCDS9685.1
    UniProtKB/Swiss-Prot
    P62273
    Related
    ENSP00000245458.6, ENST00000245458.10
    Conserved Domains (1) summary
    PTZ00218
    Location:156
    PTZ00218; 40S ribosomal protein S29; Provisional
  3. NM_001351375.1NP_001338304.1  40S ribosomal protein S29 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate first exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL139099, HY027234
    Consensus CDS
    CCDS86388.1
    Related
    ENSP00000478117.1, ENST00000557111.5
    Conserved Domains (1) summary
    cl00355
    Location:1953
    Ribosomal_S14; Ribosomal protein S14p/S29e

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    49570988..49598710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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