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MBOAT4 membrane bound O-acyltransferase domain containing 4 [ Homo sapiens (human) ]

Gene ID: 619373, updated on 22-Sep-2022

Summary

Official Symbol
MBOAT4provided by HGNC
Official Full Name
membrane bound O-acyltransferase domain containing 4provided by HGNC
Primary source
HGNC:HGNC:32311
See related
Ensembl:ENSG00000177669 MIM:611940; AllianceGenome:HGNC:32311
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GOAT; OACT4; FKSG89
Summary
Enables serine O-acyltransferase activity. Involved in peptidyl-serine octanoylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in membrane. Predicted to be integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach (RPKM 1.5), gall bladder (RPKM 0.4) and 10 other tissues See more
Orthologs
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Genomic context

See MBOAT4 in Genome Data Viewer
Location:
8p12
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (30131671..30144665, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (30410588..30423543, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (29989187..30002181, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene store-operated calcium entry associated regulatory factor Neighboring gene leptin receptor overlapping transcript like 1 Neighboring gene ribosomal protein S15a pseudogene 24 Neighboring gene uncharacterized LOC124901927 Neighboring gene dynactin subunit 6 Neighboring gene uncharacterized LOC124901928 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables O-acyltransferase activity TAS
Traceable Author Statement
more info
 
enables acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acyltransferase activity, transferring groups other than amino-acyl groups IDA
Inferred from Direct Assay
more info
PubMed 
enables serine O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in lipid modification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptide hormone processing TAS
Traceable Author Statement
more info
 
involved_in peptidyl-serine octanoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine octanoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein decanoylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ghrelin O-acyltransferase
Names
O-acyltransferase (membrane bound) domain containing 4
O-acyltransferase domain-containing protein 4
membrane-bound O-acyltransferase domain-containing protein 4
NP_001094386.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100916.2NP_001094386.1  ghrelin O-acyltransferase

    See identical proteins and their annotated locations for NP_001094386.1

    Status: VALIDATED

    Source sequence(s)
    AC026979, EU518495
    Consensus CDS
    CCDS47835.1
    UniProtKB/Swiss-Prot
    B1Q003, Q96T53
    Related
    ENSP00000314196.3, ENST00000320542.4
    Conserved Domains (1) summary
    cl00738
    Location:18427
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    30131671..30144665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    30410588..30423543 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)