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RPL39 ribosomal protein L39 [ Homo sapiens (human) ]

Gene ID: 6170, updated on 5-Jul-2020

Summary

Official Symbol
RPL39provided by HGNC
Official Full Name
ribosomal protein L39provided by HGNC
Primary source
HGNC:HGNC:10350
See related
Ensembl:ENSG00000198918 MIM:300899
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L39; RPL39P42; RPL39_23_1806
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the S39E family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein is the smallest, and one of the most basic, proteins of the ribosome. This gene is co-transcribed with the U69 small nucleolar RNA gene, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 874.5), bone marrow (RPKM 734.5) and 25 other tissues See more
Orthologs

Genomic context

See RPL39 in Genome Data Viewer
Location:
Xq24
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (119786504..119791630, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (118920467..118925622, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene septin 6 Neighboring gene microRNA 766 Neighboring gene sosondowah ankyrin repeat domain family member D Neighboring gene uncharacterized LOC107985694 Neighboring gene small nucleolar RNA, H/ACA box 69 Neighboring gene Sharpr-MPRA regulatory region 4463 Neighboring gene UPF3B regulator of nonsense mediated mRNA decay

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding TAS
Traceable Author Statement
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
structural constituent of ribosome TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
cytosolic large ribosomal subunit TAS
Traceable Author Statement
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
polysomal ribosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
60S ribosomal protein L39
Names
large ribosomal subunit protein eL39

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016250.2 RefSeqGene

    Range
    5014..10140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001000.4NP_000991.1  60S ribosomal protein L39

    See identical proteins and their annotated locations for NP_000991.1

    Status: REVIEWED

    Source sequence(s)
    BX476041
    Consensus CDS
    CCDS14586.1
    UniProtKB/Swiss-Prot
    P62891
    Related
    ENSP00000355315.3, ENST00000361575.4
    Conserved Domains (1) summary
    pfam00832
    Location:950
    Ribosomal_L39; Ribosomal L39 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    119786504..119791630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_010198.1: Suppressed sequence

    Description
    NG_010198.1: This RefSeq was permanently suppressed because it is now thought that this gene is not a pseudogene.
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