Format

Send to:

Choose Destination

RPL38 ribosomal protein L38 [ Homo sapiens (human) ]

Gene ID: 6169, updated on 9-Feb-2020

Summary

Official Symbol
RPL38provided by HGNC
Official Full Name
ribosomal protein L38provided by HGNC
Primary source
HGNC:HGNC:10349
See related
Ensembl:ENSG00000172809 MIM:604182
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L38
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L38E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome, including one located in the promoter region of the type 1 angiotensin II receptor gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 645.4), fat (RPKM 429.7) and 25 other tissues See more
Orthologs

Genomic context

See RPL38 in Genome Data Viewer
Location:
17q25.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (74203678..74210655)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72199795..72206019)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985081 Neighboring gene uncharacterized LOC105371888 Neighboring gene long intergenic non-protein coding RNA 2074 Neighboring gene uncharacterized protein MGC16275 Neighboring gene tweety family member 2 Neighboring gene uncharacterized LOC105371891 Neighboring gene dynein axonemal intermediate chain 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding TAS
Traceable Author Statement
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
90S preribosome assembly IEA
Inferred from Electronic Annotation
more info
 
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
axial mesoderm development IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic translation IDA
Inferred from Direct Assay
more info
PubMed 
middle ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
ossification IEA
Inferred from Electronic Annotation
more info
 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
sensory perception of sound IEA
Inferred from Electronic Annotation
more info
 
skeletal system development IEA
Inferred from Electronic Annotation
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
eukaryotic 80S initiation complex IEA
Inferred from Electronic Annotation
more info
 
focal adhesion HDA PubMed 
polysomal ribosome IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density EXP
Inferred from Experiment
more info
PubMed 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
60S ribosomal protein L38
Names
large ribosomal subunit protein eL38

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000999.4NP_000990.1  60S ribosomal protein L38

    See identical proteins and their annotated locations for NP_000990.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer and predominant transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC100786, BQ276548, CB124619, Z26876
    Consensus CDS
    CCDS11696.1
    UniProtKB/Swiss-Prot
    P63173
    UniProtKB/TrEMBL
    A0A024R8P8
    Related
    ENSP00000309830.6, ENST00000311111.11
    Conserved Domains (1) summary
    pfam01781
    Location:268
    Ribosomal_L38e; Ribosomal L38e protein family
  2. NM_001035258.2NP_001030335.1  60S ribosomal protein L38

    See identical proteins and their annotated locations for NP_001030335.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is the shorter transcript, lacking a segment in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC100786, CB128529
    Consensus CDS
    CCDS11696.1
    UniProtKB/Swiss-Prot
    P63173
    UniProtKB/TrEMBL
    A0A024R8P8
    Related
    ENSP00000390279.2, ENST00000439590.6
    Conserved Domains (1) summary
    pfam01781
    Location:268
    Ribosomal_L38e; Ribosomal L38e protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    74203678..74210655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center