Format

Send to:

Choose Destination

DEFB135 defensin beta 135 [ Homo sapiens (human) ]

Gene ID: 613209, updated on 23-Nov-2021

Summary

Official Symbol
DEFB135provided by HGNC
Official Full Name
defensin beta 135provided by HGNC
Primary source
HGNC:HGNC:32400
See related
Ensembl:ENSG00000205883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DEFB136
Summary
Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 8p23. [provided by RefSeq, Nov 2014]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DEFB135 in Genome Data Viewer
Location:
8p23.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (11982256..11984590)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (11839765..11842099)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379244 Neighboring gene uncharacterized LOC112268017 Neighboring gene defensin beta 136 Neighboring gene nuclear receptor binding SET domain protein 3 pseudogene Neighboring gene defensin beta 134 Neighboring gene uncharacterized LOC105379245 Neighboring gene olfactory receptor family 7 subfamily E member 160 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-defensin 135
Names
beta-defensin 136

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033017.3NP_001028189.2  beta-defensin 135 precursor

    See identical proteins and their annotated locations for NP_001028189.2

    Status: VALIDATED

    Source sequence(s)
    AC107918
    Consensus CDS
    CCDS43710.1
    UniProtKB/Swiss-Prot
    Q30KP9
    Related
    ENSP00000371643.2, ENST00000382208.3
    Conserved Domains (1) summary
    pfam13841
    Location:3665
    Defensin_beta_2; Beta defensin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    11982256..11984590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p13 PATCHES

    Range
    1363428..1365762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center