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CCDC90B coiled-coil domain containing 90B [ Homo sapiens (human) ]

Gene ID: 60492, updated on 8-Oct-2017
Official Symbol
CCDC90Bprovided by HGNC
Official Full Name
coiled-coil domain containing 90Bprovided by HGNC
Primary source
HGNC:HGNC:28108
See related
Ensembl:ENSG00000137500 Vega:OTTHUMG00000167078
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDS011; MDS025
Orthologs
Location:
11q14.1
Exon count:
10
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (83259093..83286407, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (82972498..82997445, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 42 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 4 Neighboring gene ribosomal protein L32 pseudogene 24 Neighboring gene uncharacterized LOC105369420 Neighboring gene cytochrome c, somatic pseudogene 28

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ22685, MGC104239

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
Preferred Names
coiled-coil domain-containing protein 90B, mitochondrial

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286116.1NP_001273045.1  coiled-coil domain-containing protein 90B, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_001273045.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK304769, AP000873, CN309108
    Consensus CDS
    CCDS66191.1
    UniProtKB/Swiss-Prot
    Q9GZT6
    Related
    ENSP00000390990.2, OTTHUMP00000235041, ENST00000455220.6, OTTHUMT00000392941
    Conserved Domains (1) summary
    pfam07798
    Location:52243
    DUF1640; Protein of unknown function (DUF1640)
  2. NM_001286117.1NP_001273046.1  coiled-coil domain-containing protein 90B, mitochondrial isoform c

    See identical proteins and their annotated locations for NP_001273046.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AF271782, AK304769, AP000873, BC067764, CN309108
    Consensus CDS
    CCDS66190.1
    UniProtKB/Swiss-Prot
    Q9GZT6
    Related
    ENSP00000431424.1, OTTHUMP00000235042, ENST00000525503.5, OTTHUMT00000392942
    Conserved Domains (1) summary
    pfam07798
    Location:1151
    DUF1640; Protein of unknown function (DUF1640)
  3. NM_001286118.1NP_001273047.1  coiled-coil domain-containing protein 90B, mitochondrial isoform d

    See identical proteins and their annotated locations for NP_001273047.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' coding region and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a. Variants 4 and 5 encode the same isoform (d).
    Source sequence(s)
    AK304769, AP000873, AV756714, BC067764, CN309108
    UniProtKB/Swiss-Prot
    Q9GZT6
    Conserved Domains (1) summary
    pfam07798
    Location:10154
    DUF1640; Protein of unknown function (DUF1640)
  4. NM_001286119.1NP_001273048.1  coiled-coil domain-containing protein 90B, mitochondrial isoform d

    See identical proteins and their annotated locations for NP_001273048.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate exon and lacks an exon in the 5' coding region, and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a. Variants 4 and 5 encode the same isoform (d).
    Source sequence(s)
    AF271782, AK304769, AP000873, BF131344, CN309108
    UniProtKB/Swiss-Prot
    Q9GZT6
    Conserved Domains (1) summary
    pfam07798
    Location:10154
    DUF1640; Protein of unknown function (DUF1640)
  5. NM_001286120.1NP_001273049.1  coiled-coil domain-containing protein 90B, mitochondrial isoform e

    See identical proteins and their annotated locations for NP_001273049.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two alternate exons in the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (e) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AF271782, AK304769, AP000873, BC067764, BG700162, CN309108
    UniProtKB/Swiss-Prot
    Q9GZT6
    Conserved Domains (1) summary
    pfam07798
    Location:1137
    DUF1640; Protein of unknown function (DUF1640)
  6. NM_021825.4NP_068597.2  coiled-coil domain-containing protein 90B, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_068597.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AF271782, AK304769, AP000873, CN309108
    Consensus CDS
    CCDS8266.1
    UniProtKB/Swiss-Prot
    Q9GZT6
    Related
    ENSP00000434724.1, OTTHUMP00000235040, ENST00000529689.5, OTTHUMT00000392940
    Conserved Domains (1) summary
    pfam07798
    Location:61252
    DUF1640; Protein of unknown function (DUF1640)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

    Range
    83259093..83286407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274156.3XP_005274213.1  coiled-coil domain-containing protein 90B, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005274213.1

    Conserved Domains (1) summary
    pfam07798
    Location:10154
    DUF1640; Protein of unknown function (DUF1640)
  2. XM_017018104.1XP_016873593.1  coiled-coil domain-containing protein 90B, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q9GZT6
    Related
    ENSP00000431345.1, OTTHUMP00000235044, ENST00000529611.5, OTTHUMT00000392944
    Conserved Domains (1) summary
    pfam07798
    Location:1151
    DUF1640; Protein of unknown function (DUF1640)
  3. XM_005274159.3XP_005274216.1  coiled-coil domain-containing protein 90B, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_005274216.1

    UniProtKB/Swiss-Prot
    Q9GZT6
    Conserved Domains (1) summary
    pfam07798
    Location:1151
    DUF1640; Protein of unknown function (DUF1640)
  4. XM_005274154.2XP_005274211.1  coiled-coil domain-containing protein 90B, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005274211.1

    Conserved Domains (1) summary
    pfam07798
    Location:10154
    DUF1640; Protein of unknown function (DUF1640)
  5. XM_017018103.1XP_016873592.1  coiled-coil domain-containing protein 90B, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam07798
    Location:10154
    DUF1640; Protein of unknown function (DUF1640)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    82854278..82881592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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