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MRPS35 mitochondrial ribosomal protein S35 [ Homo sapiens (human) ]

Gene ID: 60488, updated on 5-Jul-2020

Summary

Official Symbol
MRPS35provided by HGNC
Official Full Name
mitochondrial ribosomal protein S35provided by HGNC
Primary source
HGNC:HGNC:16635
See related
Ensembl:ENSG00000061794 MIM:611995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDS023; MRPS28; MRP-S28; HDCMD11P
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in kidney (RPKM 30.7), colon (RPKM 30.0) and 25 other tissues See more
Orthologs

Genomic context

See MRPS35 in Genome Data Viewer
Location:
12p11.22
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (27710773..27756304)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (27863706..27909237)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984461 Neighboring gene RAB15 effector protein Neighboring gene high mobility group box 1 pseudogene 49 Neighboring gene MANSC domain containing 4 Neighboring gene kelch like family member 42 Neighboring gene RN7SK pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC104278, DKFZp762P093

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, detection of DNA damage NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial small ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
28S ribosomal protein S35, mitochondrial
Names
28S ribosomal protein S28, mitochondrial
MRP-S35
S28mt
S35mt
mitochondrial ribosomal protein S28
mitochondrial small ribosomal subunit protein mS35

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190864.1NP_001177793.1  28S ribosomal protein S35, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_001177793.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing an internal coding exon compared to variant 1. This results in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AI538796, AK075378, BC015862, DA747094
    Consensus CDS
    CCDS53769.1
    UniProtKB/Swiss-Prot
    P82673
    Related
    ENSP00000445390.1, ENST00000538315.5
  2. NM_021821.4NP_068593.2  28S ribosomal protein S35, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_068593.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC015862, DA747094
    Consensus CDS
    CCDS8714.1
    UniProtKB/Swiss-Prot
    P82673
    Related
    ENSP00000081029.3, ENST00000081029.8
    Conserved Domains (1) summary
    pfam10213
    Location:148251
    MRP-S28; Mitochondrial ribosomal subunit protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    27710773..27756304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019780.1XP_016875269.1  28S ribosomal protein S35, mitochondrial isoform X1

    Related
    ENSP00000442137.1, ENST00000542199.1
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