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RNASE4 ribonuclease A family member 4 [ Homo sapiens (human) ]

Gene ID: 6038, updated on 13-Mar-2020

Summary

Official Symbol
RNASE4provided by HGNC
Official Full Name
ribonuclease A family member 4provided by HGNC
Primary source
HGNC:HGNC:10047
See related
Ensembl:ENSG00000258818 MIM:601030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAB1; RNS4
Summary
The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2013]
Expression
Biased expression in liver (RPKM 129.2), fat (RPKM 38.7) and 12 other tissues See more
Orthologs

Genomic context

See RNASE4 in Genome Data Viewer
Location:
14q11.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (20684560..20701216)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21152259..21168761)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene tRNA-Tyr (anticodon GTA) 5-5 Neighboring gene tRNA-Pro (anticodon TGG) 3-2 Neighboring gene angiogenin Neighboring gene uncharacterized LOC107984671 Neighboring gene RAN binding protein 20 pseudogene Neighboring gene epididymal protein 3A Neighboring gene epididymal protein 3D, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9306

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
ribonuclease A activity NAS
Non-traceable Author Statement
more info
PubMed 
ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis IDA
Inferred from Direct Assay
more info
PubMed 
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
mRNA cleavage NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribonuclease 4
Names
RNase 4
epididymis secretory sperm binding protein
ribonuclease A B1
ribonuclease, RNase A family, 4
NP_001269121.1
NP_001269122.1
NP_002928.1
NP_919412.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033053.1 RefSeqGene

    Range
    5348..22004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282192.2NP_001269121.1  ribonuclease 4 precursor

    See identical proteins and their annotated locations for NP_001269121.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AK092422, AL163636, BX247985, CA447209, DA925725
    Consensus CDS
    CCDS9555.1
    UniProtKB/Swiss-Prot
    P34096
    UniProtKB/TrEMBL
    Q53XB4
    Conserved Domains (1) summary
    smart00092
    Location:29147
    RNAse_Pc; Pancreatic ribonuclease
  2. NM_001282193.2NP_001269122.1  ribonuclease 4 precursor

    See identical proteins and their annotated locations for NP_001269122.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. All four variants encode the same protein.
    Source sequence(s)
    AK092422, AL163636, BU594423, CA447209
    Consensus CDS
    CCDS9555.1
    UniProtKB/Swiss-Prot
    P34096
    UniProtKB/TrEMBL
    Q53XB4
    Related
    ENSP00000381081.2, ENST00000397995.2
    Conserved Domains (1) summary
    smart00092
    Location:29147
    RNAse_Pc; Pancreatic ribonuclease
  3. NM_002937.5NP_002928.1  ribonuclease 4 precursor

    See identical proteins and their annotated locations for NP_002928.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 4. All four variants encode the same protein.
    Source sequence(s)
    AK092422, AL163636, CA447209
    Consensus CDS
    CCDS9555.1
    UniProtKB/Swiss-Prot
    P34096
    UniProtKB/TrEMBL
    Q53XB4
    Related
    ENSP00000452245.1, ENST00000555835.3
    Conserved Domains (1) summary
    smart00092
    Location:29147
    RNAse_Pc; Pancreatic ribonuclease
  4. NM_194431.3NP_919412.1  ribonuclease 4 precursor

    See identical proteins and their annotated locations for NP_919412.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. All four variants encode the same protein.
    Source sequence(s)
    AL163636, BG616902, CA447209, DR003809
    Consensus CDS
    CCDS9555.1
    UniProtKB/Swiss-Prot
    P34096
    UniProtKB/TrEMBL
    Q53XB4
    Related
    ENSP00000451624.1, ENST00000555597.1
    Conserved Domains (1) summary
    smart00092
    Location:29147
    RNAse_Pc; Pancreatic ribonuclease

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    20684560..20701216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_194430.1: Suppressed sequence

    Description
    NM_194430.1: This RefSeq was permanently suppressed because it contains the wrong CDS.
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