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RNASE2 ribonuclease A family member 2 [ Homo sapiens (human) ]

Gene ID: 6036, updated on 7-Dec-2018

Summary

Official Symbol
RNASE2provided by HGNC
Official Full Name
ribonuclease A family member 2provided by HGNC
Primary source
HGNC:HGNC:10045
See related
Ensembl:ENSG00000169385 MIM:131410
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDN; RAF3; RNS2
Summary
The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses. [provided by RefSeq, Oct 2014]
Expression
Restricted expression toward bone marrow (RPKM 516.0) See more
Orthologs

Genomic context

See RNASE2 in Genome Data Viewer
Location:
14q11.2
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (20955471..20956435)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21423630..21424594)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507513 Neighboring gene ribonuclease A family member 3 Neighboring gene ribonuclease A family member 2 pseudogene Neighboring gene RNA, 7SL, cytoplasmic 189, pseudogene Neighboring gene coiled-coil domain containing 107 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT lipopolysaccharide binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
ribonuclease A activity IEA
Inferred from Electronic Annotation
more info
 
ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA catabolic process TAS
Traceable Author Statement
more info
PubMed 
RNA phosphodiester bond hydrolysis IDA
Inferred from Direct Assay
more info
PubMed 
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
NOT defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
NOT induction of bacterial agglutination IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
azurophil granule lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
non-secretory ribonuclease
Names
RNase 2
RNase UpI-2
eosinophil-derived neurotoxin
ribonuclease 2
ribonuclease A F3
ribonuclease US
ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
NP_002925.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002934.3NP_002925.1  non-secretory ribonuclease precursor

    See identical proteins and their annotated locations for NP_002925.1

    Status: REVIEWED

    Source sequence(s)
    AL355922, M28129, X55988
    Consensus CDS
    CCDS9561.1
    UniProtKB/Swiss-Prot
    P10153
    UniProtKB/TrEMBL
    W0UV60
    Related
    ENSP00000303276.2, ENST00000304625.2
    Conserved Domains (1) summary
    smart00092
    Location:31161
    RNAse_Pc; Pancreatic ribonuclease

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    20955471..20956435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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