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RMRP RNA component of mitochondrial RNA processing endoribonuclease [ Homo sapiens (human) ]

Gene ID: 6023, updated on 25-Oct-2022

Summary

Official Symbol
RMRPprovided by HGNC
Official Full Name
RNA component of mitochondrial RNA processing endoribonucleaseprovided by HGNC
Primary source
HGNC:HGNC:10031
See related
Ensembl:ENSG00000277027 MIM:157660; AllianceGenome:HGNC:10031
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHH; NME1; RRP2; RMRPR
Summary
This gene encodes the RNA component of mitochondrial RNA processing endoribonuclease, which cleaves mitochondrial RNA at a priming site of mitochondrial DNA replication. This RNA also interacts with the telomerase reverse transcriptase catalytic subunit to form a distinct ribonucleoprotein complex that has RNA-dependent RNA polymerase activity and produces double-stranded RNAs that can be processed into small interfering RNA. Mutations in this gene are associated with cartilage-hair hypoplasia.[provided by RefSeq, Mar 2010]
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Genomic context

See RMRP in Genome Data Viewer
Location:
9p13.3
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (35657751..35658018, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (35678403..35678670, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35657748..35658015, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene CD72 molecule Neighboring gene uncharacterized LOC101926948 Neighboring gene signaling threshold regulating transmembrane adaptor 1 Neighboring gene Sharpr-MPRA regulatory region 3743 Neighboring gene coiled-coil domain containing 107 Neighboring gene Rho guanine nucleotide exchange factor 39

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • RNase MRP RNA

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA polymerase binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to RNA-dependent RNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ribonuclease MRP activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to template-free RNA nucleotidyltransferase IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
involved_in RNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in siRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in siRNA transcription IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of TERT-RMRP complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 
part_of ribonuclease MRP complex IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017041.1 RefSeqGene

    Range
    5001..5268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_163

RNA

  1. NR_003051.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    DW422801, DW423815
    Related
    ENST00000363046.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    35657751..35658018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    35678403..35678670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)