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RMRP RNA component of mitochondrial RNA processing endoribonuclease [ Homo sapiens (human) ]

Gene ID: 6023, updated on 17-Oct-2021

Summary

Official Symbol
RMRPprovided by HGNC
Official Full Name
RNA component of mitochondrial RNA processing endoribonucleaseprovided by HGNC
Primary source
HGNC:HGNC:10031
See related
Ensembl:ENSG00000269900 MIM:157660
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHH; NME1; RRP2; RMRPR
Summary
This gene encodes the RNA component of mitochondrial RNA processing endoribonuclease, which cleaves mitochondrial RNA at a priming site of mitochondrial DNA replication. This RNA also interacts with the telomerase reverse transcriptase catalytic subunit to form a distinct ribonucleoprotein complex that has RNA-dependent RNA polymerase activity and produces double-stranded RNAs that can be processed into small interfering RNA. Mutations in this gene are associated with cartilage-hair hypoplasia.[provided by RefSeq, Mar 2010]
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Genomic context

See RMRP in Genome Data Viewer
Location:
9p13.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (35657751..35658018, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35657748..35658015, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101926948 Neighboring gene signaling threshold regulating transmembrane adaptor 1 Neighboring gene coiled-coil domain containing 107 Neighboring gene Rho guanine nucleotide exchange factor 39 Neighboring gene RNA, 7SL, cytoplasmic 22, pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017041.1 RefSeqGene

    Range
    5001..5268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_163

RNA

  1. NR_003051.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    DW422801, DW423815
    Related
    ENST00000602361.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    35657751..35658018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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