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RGS13 regulator of G protein signaling 13 [ Homo sapiens (human) ]

Gene ID: 6003, updated on 10-Dec-2024

Summary

Official Symbol
RGS13provided by HGNC
Official Full Name
regulator of G protein signaling 13provided by HGNC
Primary source
HGNC:HGNC:9995
See related
Ensembl:ENSG00000127074 MIM:607190; AllianceGenome:HGNC:9995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 52.7), appendix (RPKM 9.2) and 2 other tissues See more
Orthologs
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Genomic context

See RGS13 in Genome Data Viewer
Location:
1q31.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (192636147..192660311)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (191983284..192007378)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (192605277..192629441)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371664 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2263 Neighboring gene regulator of G protein signaling 1 Neighboring gene uncharacterized LOC107985241 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:192637387-192637888 Neighboring gene HNF1 motif-containing MPRA enhancer 26 Neighboring gene ribosomal protein S27a pseudogene 5 Neighboring gene microRNA 4426 Neighboring gene uncharacterized LOC105371665

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC17173

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 13
Names
regulator of G-protein signalling 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002927.5NP_002918.1  regulator of G-protein signaling 13

    See identical proteins and their annotated locations for NP_002918.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AL136454, AL596119
    Consensus CDS
    CCDS1376.1
    UniProtKB/Swiss-Prot
    O14921, Q6PGR2, Q8TD63, Q9BX45
    Related
    ENSP00000375853.2, ENST00000391995.7
    Conserved Domains (1) summary
    cd08716
    Location:35148
    RGS_RGS13; Regulator of G protein signaling (RGS) domain found in the RGS13 protein
  2. NM_144766.3NP_658912.1  regulator of G-protein signaling 13

    See identical proteins and their annotated locations for NP_658912.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL136454, AL596119
    Consensus CDS
    CCDS1376.1
    UniProtKB/Swiss-Prot
    O14921, Q6PGR2, Q8TD63, Q9BX45
    Related
    ENSP00000442837.1, ENST00000543215.5
    Conserved Domains (1) summary
    cd08716
    Location:35148
    RGS_RGS13; Regulator of G protein signaling (RGS) domain found in the RGS13 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    192636147..192660311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    191983284..192007378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)