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RGS13 regulator of G protein signaling 13 [ Homo sapiens (human) ]

Gene ID: 6003, updated on 11-Sep-2019

Summary

Official Symbol
RGS13provided by HGNC
Official Full Name
regulator of G protein signaling 13provided by HGNC
Primary source
HGNC:HGNC:9995
See related
Ensembl:ENSG00000127074 MIM:607190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 52.7), appendix (RPKM 9.2) and 2 other tissues See more
Orthologs

Genomic context

See RGS13 in Genome Data Viewer
Location:
1q31.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (192636147..192660311)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (192605268..192629441)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371664 Neighboring gene regulator of G protein signaling 1 Neighboring gene uncharacterized LOC107985241 Neighboring gene HNF1 motif-containing MPRA enhancer 26 Neighboring gene ribosomal protein S27a pseudogene 5 Neighboring gene microRNA 4426

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC17173

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 13
Names
regulator of G-protein signalling 13

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002927.5NP_002918.1  regulator of G-protein signaling 13

    See identical proteins and their annotated locations for NP_002918.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AL136454, AL596119
    Consensus CDS
    CCDS1376.1
    UniProtKB/Swiss-Prot
    O14921
    UniProtKB/TrEMBL
    A0A024R989
    Related
    ENSP00000375853.2, ENST00000391995.6
    Conserved Domains (1) summary
    cd08716
    Location:35148
    RGS_RGS13; Regulator of G protein signaling (RGS) domain found in the RGS13 protein
  2. NM_144766.3NP_658912.1  regulator of G-protein signaling 13

    See identical proteins and their annotated locations for NP_658912.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL136454, AL596119
    Consensus CDS
    CCDS1376.1
    UniProtKB/Swiss-Prot
    O14921
    UniProtKB/TrEMBL
    A0A024R989
    Related
    ENSP00000442837.1, ENST00000543215.5
    Conserved Domains (1) summary
    cd08716
    Location:35148
    RGS_RGS13; Regulator of G protein signaling (RGS) domain found in the RGS13 protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    192636147..192660311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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