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RGS10 regulator of G protein signaling 10 [ Homo sapiens (human) ]

Gene ID: 6001, updated on 7-Sep-2023

Summary

Official Symbol
RGS10provided by HGNC
Official Full Name
regulator of G protein signaling 10provided by HGNC
Primary source
HGNC:HGNC:9992
See related
Ensembl:ENSG00000148908 MIM:602856; AllianceGenome:HGNC:9992
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 32.4), appendix (RPKM 20.0) and 24 other tissues See more
Orthologs
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Genomic context

See RGS10 in Genome Data Viewer
Location:
10q26.11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (119499817..119542719, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (120395411..120438320, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (121259329..121302231, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase 5 Neighboring gene uncharacterized LOC105378511 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121100212-121100805 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121100806-121101398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121108919-121109420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121150987-121151487 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:121160908-121162107 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121164620-121165120 Neighboring gene microRNA 4681 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121203591-121204381 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121210069-121210568 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121214023-121214544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121225296-121225796 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:121239005-121239584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121269325-121269826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121269827-121270326 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121275942-121276524 Neighboring gene NANOG hESC enhancer GRCh37_chr10:121303486-121303994 Neighboring gene uncharacterized LOC105378512 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121355707-121356705 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121356706-121357703 Neighboring gene Sharpr-MPRA regulatory region 3145 Neighboring gene TIA1 cytotoxic granule associated RNA binding protein like 1 Neighboring gene RAD1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 10
Names
regulator of G-protein signalling 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005339.2NP_001005339.1  regulator of G-protein signaling 10 isoform a

    See identical proteins and their annotated locations for NP_001005339.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC012468, AI219612, AL355273, AL547312, BC009361, BF685740, BG763741, BM782346, BM914660, CB112318, CB124184
    Consensus CDS
    CCDS31294.1
    UniProtKB/Swiss-Prot
    A8K408, B1AMR8, O43665, Q6IAZ6, Q96GN0
    Related
    ENSP00000358099.2, ENST00000369103.3
    Conserved Domains (1) summary
    cd08741
    Location:42154
    RGS_RGS10; Regulator of G protein signaling (RGS) domain found in the RGS10 protein
  2. NM_002925.4NP_002916.1  regulator of G-protein signaling 10 isoform b

    See identical proteins and their annotated locations for NP_002916.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AI219612, AL355273, AL592286, AV707839, BC009361, BF685740, BM914660
    Consensus CDS
    CCDS41572.1
    UniProtKB/Swiss-Prot
    O43665
    Related
    ENSP00000376605.1, ENST00000392865.5
    Conserved Domains (1) summary
    cd08741
    Location:28140
    RGS_RGS10; Regulator of G protein signaling (RGS) domain found in the RGS10 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    119499817..119542719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    120395411..120438320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)