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RGS7 regulator of G protein signaling 7 [ Homo sapiens (human) ]

Gene ID: 6000, updated on 8-Dec-2018

Summary

Official Symbol
RGS7provided by HGNC
Official Full Name
regulator of G protein signaling 7provided by HGNC
Primary source
HGNC:HGNC:10003
See related
Ensembl:ENSG00000182901 MIM:602517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 5.9), adrenal (RPKM 1.5) and 2 other tissues See more
Orthologs

Genomic context

See RGS7 in Genome Data Viewer
Location:
1q43; 1q23.1
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (240775193..241357274, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (240938817..241520505, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506929 Neighboring gene THAP domain containing 12 pseudogene 8 Neighboring gene riboflavin kinase pseudogene 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 42 Neighboring gene ribosomal protein lateral stalk subunit P1 pseudogene 2 Neighboring gene microRNA 3123 Neighboring gene ribosomal protein L36 pseudogene 6 Neighboring gene uncharacterized LOC105373230 Neighboring gene fumarate hydratase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies in african americans provides insights into the genetic architecture of type 2 diabetes.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from BioSystems

  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • Chaperonin-mediated protein folding, organism-specific biosystem (from REACTOME)
    Chaperonin-mediated protein folding, organism-specific biosystemThe eukaryotic chaperonin TCP-1 ring complex (TRiC/ CCT) plays an essential role in the folding of a subset of proteins prominent among which are the actins and tubulins (reviewed in Altschuler and...
  • Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, organism-specific biosystem (from REACTOME)
    Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, organism-specific biosystemThe chaperonin complex TRiC/CCT is needed for the proper folding of all five G-protein beta subunits (Wells et al. 2006). TRiC/CCT cooperates with the phosducin-like protein PDCL (commonly known as P...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Protein folding, organism-specific biosystem (from REACTOME)
    Protein folding, organism-specific biosystemDue to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein beta-subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein folding TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 7
Names
regulator of G-protein signaling RGS7
regulator of G-protein signalling 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282773.2NP_001269702.1  regulator of G-protein signaling 7 isoform 2

    See identical proteins and their annotated locations for NP_001269702.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (2) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF493930, AL365184, AW872845, BC022009, BI547250, DA085997, DA605226, R43370
    Consensus CDS
    CCDS60457.1
    UniProtKB/Swiss-Prot
    P49802
    Related
    ENSP00000341242.2, ENST00000348120.6
    Conserved Domains (3) summary
    smart00224
    Location:203263
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:273393
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:2976
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  2. NM_001282775.2NP_001269704.1  regulator of G-protein signaling 7 isoform 3

    See identical proteins and their annotated locations for NP_001269704.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and contains another alternate exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF493931, AW872845, BC022009, BI547250, DA085997, DA605226, R43370
    Consensus CDS
    CCDS60459.1
    UniProtKB/Swiss-Prot
    P49802
    Related
    ENSP00000355521.1, ENST00000366563.5
    Conserved Domains (3) summary
    smart00224
    Location:256316
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:326446
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:29116
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  3. NM_001282778.2NP_001269707.1  regulator of G-protein signaling 7 isoform 4

    See identical proteins and their annotated locations for NP_001269707.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AW872845, AY587875, BC022009, BI547250, DA085997, DA605226, R43370
    Consensus CDS
    CCDS60458.1
    UniProtKB/Swiss-Prot
    P49802
    Related
    ENSP00000355522.1, ENST00000366564.5
    Conserved Domains (3) summary
    smart00224
    Location:256316
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:326446
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:29116
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  4. NM_001350113.1NP_001337042.1  regulator of G-protein signaling 7 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in its 5' UTR, resulting in use of a downstream start codon, and includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and longer 3' UTR. The resulting isoform (5) has a shorter N-terminus and a distinct C-terminus compared to isoform 1. Variants 5 and 6 encode the same protein (isoform 5).
    Source sequence(s)
    AF493931, AL359764, AW872845, BC022009, BI547250, DA085997, DA605226, R43370
    Conserved Domains (3) summary
    smart00224
    Location:230290
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:300420
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:390
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  5. NM_001350114.1NP_001337043.1  regulator of G-protein signaling 7 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate exon in its 5' UTR, resulting in use of a downstream start codon, and includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and longer 3' UTR. The resulting isoform (5) has a shorter N-terminus and a distinct C-terminus compared to isoform 1. Variants 5 and 6 encode the same protein (isoform 5).
    Source sequence(s)
    AF493931, AL592076, AW872845, BC022009, BI547250, DA085997, DA605226, R43370
    Conserved Domains (3) summary
    smart00224
    Location:230290
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:300420
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:390
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  6. NM_001350115.1NP_001337044.1  regulator of G-protein signaling 7 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains an alternate exon in its 5' UTR, resulting in use of a downstream start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (6) has a shorter N-terminus and lacks an internal segment compared to isoform 1. Variants 7 and 8 encode the same protein (isoform 6).
    Source sequence(s)
    AF493931, AL359764, AW872845, BC022009, BI547250, DA085997, DA605226, R43370
    Conserved Domains (3) summary
    smart00224
    Location:230290
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:300420
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:390
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  7. NM_001350116.1NP_001337045.1  regulator of G-protein signaling 7 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in its 5' UTR, resulting in use of a downstream start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (6) has a shorter N-terminus and lacks an internal segment compared to isoform 1. Variants 7 and 8 encode the same protein (isoform 6).
    Source sequence(s)
    AF493931, AL592076, AW872845, BC022009, DA085997, DA605226, R43370
    Conserved Domains (3) summary
    smart00224
    Location:230290
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:300420
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:390
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  8. NM_001364886.1NP_001351815.1  regulator of G-protein signaling 7 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) encodes the longest isoform (7).
    Source sequence(s)
    AL359764, AL365184, AL512307, AL590682
    Conserved Domains (3) summary
    smart00224
    Location:256316
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:326446
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:29116
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  9. NM_002924.6NP_002915.3  regulator of G-protein signaling 7 isoform 1

    See identical proteins and their annotated locations for NP_002915.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL365184, AW872845, BC022009, BI547250, DA605226, R43370
    Consensus CDS
    CCDS31071.1
    UniProtKB/Swiss-Prot
    P49802
    Related
    ENSP00000355523.1, ENST00000366565.5
    Conserved Domains (3) summary
    smart00224
    Location:256316
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:326446
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:29116
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    240775193..241357274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002004.2XP_016857493.1  regulator of G-protein signaling 7 isoform X5

  2. XM_017002009.1XP_016857498.1  regulator of G-protein signaling 7 isoform X7

    Conserved Domains (3) summary
    smart00224
    Location:230290
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:300420
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:390
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  3. XM_017002013.1XP_016857502.1  regulator of G-protein signaling 7 isoform X10

  4. XM_017002003.2XP_016857492.1  regulator of G-protein signaling 7 isoform X4

  5. XM_017002001.2XP_016857490.1  regulator of G-protein signaling 7 isoform X2

  6. XM_017002002.2XP_016857491.1  regulator of G-protein signaling 7 isoform X3

    Conserved Domains (3) summary
    smart00224
    Location:230290
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:300420
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:390
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  7. XM_017002005.2XP_016857494.1  regulator of G-protein signaling 7 isoform X6

    UniProtKB/TrEMBL
    B7Z257
    Conserved Domains (3) summary
    smart00224
    Location:230290
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:300420
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:390
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  8. XM_005273218.4XP_005273275.1  regulator of G-protein signaling 7 isoform X1

    UniProtKB/Swiss-Prot
    P49802
    Conserved Domains (3) summary
    smart00224
    Location:256316
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:326446
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:29116
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  9. XM_011544246.3XP_011542548.1  regulator of G-protein signaling 7 isoform X3

    See identical proteins and their annotated locations for XP_011542548.1

    Conserved Domains (3) summary
    smart00224
    Location:230290
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:300420
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:390
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  10. XM_006711800.4XP_006711863.1  regulator of G-protein signaling 7 isoform X3

    See identical proteins and their annotated locations for XP_006711863.1

    Conserved Domains (3) summary
    smart00224
    Location:230290
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:300420
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:390
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  11. XM_011544247.3XP_011542549.1  regulator of G-protein signaling 7 isoform X3

    See identical proteins and their annotated locations for XP_011542549.1

    Conserved Domains (3) summary
    smart00224
    Location:230290
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:300420
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:390
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  12. XM_017002011.2XP_016857500.1  regulator of G-protein signaling 7 isoform X8

  13. XM_017002012.2XP_016857501.1  regulator of G-protein signaling 7 isoform X9

    UniProtKB/TrEMBL
    B7Z223
    Conserved Domains (3) summary
    smart00224
    Location:172232
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:242362
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cl02442
    Location:132
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
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