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RGS7 regulator of G protein signaling 7 [ Homo sapiens (human) ]

Gene ID: 6000, updated on 6-Jun-2024

Summary

Official Symbol
RGS7provided by HGNC
Official Full Name
regulator of G protein signaling 7provided by HGNC
Primary source
HGNC:HGNC:10003
See related
Ensembl:ENSG00000182901 MIM:602517; AllianceGenome:HGNC:10003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables G-protein beta-subunit binding activity and GTPase activator activity. Involved in positive regulation of GTPase activity. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 5.9), adrenal (RPKM 1.5) and 2 other tissues See more
Orthologs
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Genomic context

See RGS7 in Genome Data Viewer
Location:
1q43; 1q23.1
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (240774742..241357230, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (240186136..240768709, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (240938042..241520530, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506929 Neighboring gene THAP domain containing 12 pseudogene 8 Neighboring gene uncharacterized LOC124904602 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:241051410-241051937 Neighboring gene riboflavin kinase pseudogene 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_6389 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:241099640-241100839 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 42 Neighboring gene NANOG hESC enhancer GRCh37_chr1:241133415-241133985 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_6394 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:241175575-241176086 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:241208875-241209433 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:241208316-241208874 Neighboring gene ribosomal protein lateral stalk subunit P1 pseudogene 2 Neighboring gene NANOG hESC enhancer GRCh37_chr1:241229736-241230326 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:241252482-241252653 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:241305709-241306361 Neighboring gene microRNA 3123 Neighboring gene Sharpr-MPRA regulatory region 3307 Neighboring gene MPRA-validated peak795 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2006 Neighboring gene uncharacterized LOC124904601 Neighboring gene ribosomal protein L36 pseudogene 6 Neighboring gene NANOG hESC enhancer GRCh37_chr1:241581573-241582074 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:241602586-241603173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2007 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:241682833-241683429 Neighboring gene fumarate hydratase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies in african americans provides insights into the genetic architecture of type 2 diabetes.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
enables G-protein beta-subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 7
Names
regulator of G-protein signaling RGS7
regulator of G-protein signalling 7

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282773.2NP_001269702.1  regulator of G-protein signaling 7 isoform 2

    See identical proteins and their annotated locations for NP_001269702.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (2) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF493930, AL365184, AW872845, BC022009, BI547250, DA085997, DA605226, R43370
    Consensus CDS
    CCDS60457.1
    UniProtKB/TrEMBL
    A0A8I5KR27
    Related
    ENSP00000341242.2, ENST00000348120.6
    Conserved Domains (4) summary
    smart00224
    Location:203263
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:273393
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:2976
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    pfam18148
    Location:74161
    RGS_DHEX; Regulator of G-protein signalling DHEX domain
  2. NM_001282775.2NP_001269704.1  regulator of G-protein signaling 7 isoform 3

    See identical proteins and their annotated locations for NP_001269704.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and contains another alternate exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF493931, AW872845, BC022009, BI547250, DA085997, DA605226, R43370
    Consensus CDS
    CCDS60459.1
    UniProtKB/TrEMBL
    A0A8I5KRS1
    Related
    ENSP00000355521.1, ENST00000366563.5
    Conserved Domains (4) summary
    smart00224
    Location:256316
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:326446
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:29116
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    pfam18148
    Location:113214
    RGS_DHEX; Regulator of G-protein signalling DHEX domain
  3. NM_001282778.2NP_001269707.1  regulator of G-protein signaling 7 isoform 4

    See identical proteins and their annotated locations for NP_001269707.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AW872845, AY587875, BC022009, BI547250, DA085997, DA605226, R43370
    Consensus CDS
    CCDS60458.1
    UniProtKB/TrEMBL
    A0A8I5KY39
    Related
    ENSP00000355522.1, ENST00000366564.5
    Conserved Domains (4) summary
    smart00224
    Location:256316
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:326446
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:29116
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    pfam18148
    Location:113214
    RGS_DHEX; Regulator of G-protein signalling DHEX domain
  4. NM_001350113.2NP_001337042.1  regulator of G-protein signaling 7 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in its 5' UTR, resulting in use of a downstream start codon, and includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and longer 3' UTR. The resulting isoform (5) has a shorter N-terminus and a distinct C-terminus compared to isoform 1. Variants 5 and 6 encode the same protein (isoform 5).
    Source sequence(s)
    AF493931, AL359764, AW872845, BC022009, DA085997, DA605226, R43370
    Consensus CDS
    CCDS91177.1
    UniProtKB/TrEMBL
    A0A8I5KRS1, B7Z257
    Conserved Domains (4) summary
    smart00224
    Location:230290
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:300420
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:390
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    pfam18148
    Location:87188
    RGS_DHEX; Regulator of G-protein signalling DHEX domain
  5. NM_001350114.2NP_001337043.1  regulator of G-protein signaling 7 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate exon in its 5' UTR, resulting in use of a downstream start codon, and includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and longer 3' UTR. The resulting isoform (5) has a shorter N-terminus and a distinct C-terminus compared to isoform 1. Variants 5 and 6 encode the same protein (isoform 5).
    Source sequence(s)
    AF493931, AL592076, AW872845, BC022009, DA085997, DA605226, R43370
    Consensus CDS
    CCDS91177.1
    UniProtKB/TrEMBL
    A0A8I5KRS1, B7Z257
    Related
    ENSP00000510372.1, ENST00000685936.1
    Conserved Domains (4) summary
    smart00224
    Location:230290
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:300420
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:390
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    pfam18148
    Location:87188
    RGS_DHEX; Regulator of G-protein signalling DHEX domain
  6. NM_001350115.2NP_001337044.1  regulator of G-protein signaling 7 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains an alternate exon in its 5' UTR, resulting in use of a downstream start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (6) has a shorter N-terminus and lacks an internal segment compared to isoform 1. Variants 7 and 8 encode the same protein (isoform 6).
    Source sequence(s)
    AF493931, AL359764, AW872845, BC022009, DA085997, DA605226, R43370
    Consensus CDS
    CCDS91176.1
    UniProtKB/TrEMBL
    A0A8I5KXW5, A0A8I5KY39
    Related
    ENSP00000509046.1, ENST00000692410.1
    Conserved Domains (3) summary
    smart00224
    Location:230290
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:300420
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:390
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  7. NM_001350116.1NP_001337045.1  regulator of G-protein signaling 7 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in its 5' UTR, resulting in use of a downstream start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (6) has a shorter N-terminus and lacks an internal segment compared to isoform 1. Variants 7 and 8 encode the same protein (isoform 6).
    Source sequence(s)
    AF493931, AL592076, AW872845, BC022009, DA085997, DA605226, R43370
    Consensus CDS
    CCDS91176.1
    UniProtKB/TrEMBL
    A0A8I5KXW5, A0A8I5KY39
    Related
    ENST00000690236.1
    Conserved Domains (3) summary
    smart00224
    Location:230290
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:300420
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:390
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  8. NM_001364886.1NP_001351815.1  regulator of G-protein signaling 7 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) encodes the longest isoform (7).
    Source sequence(s)
    AL359764, AL365184, AL512307, AL590682
    Consensus CDS
    CCDS91181.1
    UniProtKB/Swiss-Prot
    P49802, Q5T3H4, Q8TD66, Q8TD67, Q8WW09, Q9UNU7, Q9Y6B9
    UniProtKB/TrEMBL
    A0A8I5KRS1
    Related
    ENSP00000404399.2, ENST00000440928.6
    Conserved Domains (4) summary
    smart00224
    Location:256316
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:326446
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:29116
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    pfam18148
    Location:113214
    RGS_DHEX; Regulator of G-protein signalling DHEX domain
  9. NM_001374806.1NP_001361735.1  regulator of G-protein signaling 7 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL359764, AL365184, AL512307, AL590682
    UniProtKB/TrEMBL
    A0A8I5KRS1
    Conserved Domains (4) summary
    smart00224
    Location:239299
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:309429
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:2999
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    pfam18148
    Location:96197
    RGS_DHEX; Regulator of G-protein signalling DHEX domain
  10. NM_001374807.1NP_001361736.1  regulator of G-protein signaling 7 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL359764, AL365184, AL512307, AL590682
    Consensus CDS
    CCDS91178.1
    UniProtKB/TrEMBL
    A0A8I5KY39, A0A8I5KZ50
    Related
    ENSP00000510735.1, ENST00000690019.1
    Conserved Domains (4) summary
    smart00224
    Location:239299
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:309429
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:2999
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    pfam18148
    Location:96197
    RGS_DHEX; Regulator of G-protein signalling DHEX domain
  11. NM_001374808.1NP_001361737.1  regulator of G-protein signaling 7 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL359764, AL365184, AL512307, AL590682
    Consensus CDS
    CCDS91177.1
    UniProtKB/TrEMBL
    A0A8I5KRS1, B7Z257
    Conserved Domains (4) summary
    smart00224
    Location:230290
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:300420
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:390
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    pfam18148
    Location:87188
    RGS_DHEX; Regulator of G-protein signalling DHEX domain
  12. NM_001374809.1NP_001361738.1  regulator of G-protein signaling 7 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL359764, AL365184, AL512307, AL590682
    Conserved Domains (3) summary
    smart00224
    Location:163223
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:233353
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    pfam18148
    Location:71121
    RGS_DHEX; Regulator of G-protein signalling DHEX domain
  13. NM_001374810.1NP_001361739.1  regulator of G-protein signaling 7 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL359764, AL365184, AL512307, AL590682
    UniProtKB/TrEMBL
    Q5T3H5
    Conserved Domains (3) summary
    smart00224
    Location:163223
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:233353
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    pfam18148
    Location:71121
    RGS_DHEX; Regulator of G-protein signalling DHEX domain
  14. NM_001374811.1NP_001361740.1  regulator of G-protein signaling 7 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL359764, AL365184, AL512307, AL590682
    UniProtKB/TrEMBL
    A0A8I5KY39
    Conserved Domains (4) summary
    smart00224
    Location:203263
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:273393
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:2976
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    pfam18148
    Location:74161
    RGS_DHEX; Regulator of G-protein signalling DHEX domain
  15. NM_001374812.1NP_001361741.1  regulator of G-protein signaling 7 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL359764, AL365184, AL512307, AL590682
    UniProtKB/TrEMBL
    A0A8I5KZ23
    Conserved Domains (4) summary
    smart00224
    Location:231291
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:301421
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:29116
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    pfam18148
    Location:113203
    RGS_DHEX; Regulator of G-protein signalling DHEX domain
  16. NM_001374813.1NP_001361742.1  regulator of G-protein signaling 7 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL359764, AL365184, AL512307, AL590682
    Conserved Domains (2) summary
    smart00224
    Location:85145
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:155275
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
  17. NM_001374814.1NP_001361743.1  regulator of G-protein signaling 7 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AL359764, AL365184, AL512307, AL590682
    Consensus CDS
    CCDS91179.1
    UniProtKB/TrEMBL
    A0A8I5KR27, A0A8I5QJU0
    Related
    ENSP00000510458.1, ENST00000689115.1
    Conserved Domains (4) summary
    smart00224
    Location:203263
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:273393
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:2976
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    pfam18148
    Location:74161
    RGS_DHEX; Regulator of G-protein signalling DHEX domain
  18. NM_001374815.1NP_001361744.1  regulator of G-protein signaling 7 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AL359764, AL365184, AL512307, AL590682
    Consensus CDS
    CCDS91180.1
    UniProtKB/TrEMBL
    A0A8I5KRS1, A0A8I5KUA7
    Related
    ENSP00000508919.1, ENST00000691989.1
    Conserved Domains (4) summary
    cd08738
    Location:289409
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:29116
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    pfam18148
    Location:113214
    RGS_DHEX; Regulator of G-protein signalling DHEX domain
    pfam00631
    Location:256282
    G-gamma; GGL domain
  19. NM_001374816.1NP_001361745.1  regulator of G-protein signaling 7 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AL359764, AL365184, AL512307, AL590682
    UniProtKB/TrEMBL
    A0A8I5KY39
    Conserved Domains (4) summary
    cd08738
    Location:289409
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:29116
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    pfam18148
    Location:113214
    RGS_DHEX; Regulator of G-protein signalling DHEX domain
    cl00069
    Location:256282
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors
  20. NM_002924.6NP_002915.3  regulator of G-protein signaling 7 isoform 1

    See identical proteins and their annotated locations for NP_002915.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL365184, AW872845, BC022009, BI547250, DA605226, R43370
    Consensus CDS
    CCDS31071.1
    UniProtKB/TrEMBL
    A0A8I5KY39
    Related
    ENSP00000355523.1, ENST00000366565.5
    Conserved Domains (3) summary
    smart00224
    Location:256316
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:326446
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:29116
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    240774742..241357230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426980.1XP_047282936.1  regulator of G-protein signaling 7 isoform X1

    UniProtKB/TrEMBL
    A0A8I5KY39
  2. XM_017002009.2XP_016857498.1  regulator of G-protein signaling 7 isoform X2

    UniProtKB/TrEMBL
    A0A8I5KXW5, A0A8I5KY39
    Conserved Domains (3) summary
    smart00224
    Location:230290
    GGL; G protein gamma subunit-like motifs
    cd08738
    Location:300420
    RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
    cd04450
    Location:390
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    240186136..240768709 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338041.1XP_054194016.1  regulator of G-protein signaling 7 isoform X3

    UniProtKB/TrEMBL
    A0A8I5KRS1
  2. XM_054338043.1XP_054194018.1  regulator of G-protein signaling 7 isoform X3

    UniProtKB/TrEMBL
    A0A8I5KRS1
  3. XM_054338044.1XP_054194019.1  regulator of G-protein signaling 7 isoform X1

    UniProtKB/TrEMBL
    A0A8I5KY39
  4. XM_054338042.1XP_054194017.1  regulator of G-protein signaling 7 isoform X3

    UniProtKB/TrEMBL
    A0A8I5KRS1
  5. XM_054338045.1XP_054194020.1  regulator of G-protein signaling 7 isoform X2

    UniProtKB/TrEMBL
    A0A8I5KXW5, A0A8I5KY39