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RFPL1 ret finger protein like 1 [ Homo sapiens (human) ]

Gene ID: 5988, updated on 24-Nov-2020

Summary

Official Symbol
RFPL1provided by HGNC
Official Full Name
ret finger protein like 1provided by HGNC
Primary source
HGNC:HGNC:9977
See related
Ensembl:ENSG00000128250 MIM:605968
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF78
Expression
Biased expression in brain (RPKM 3.4), testis (RPKM 1.0) and 3 other tissues See more
Orthologs

Genomic context

See RFPL1 in Genome Data Viewer
Location:
22q12.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (29403031..29442490)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (29834572..29838444)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene RAS like family 10 member A Neighboring gene small nucleolar RNA, C/D box 125 Neighboring gene adaptor related protein complex 1 subunit beta 1 Neighboring gene uncharacterized LOC102723305 Neighboring gene ret finger protein like 4A pseudogene 6 Neighboring gene RFPL1 antisense RNA 1 Neighboring gene uncharacterized LOC107985541 Neighboring gene neurofilament heavy

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of carotid atherosclerosis in HIV-infected men.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC132428

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ret finger protein-like 1
Names
RING finger protein 78

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021026.2NP_066306.2  ret finger protein-like 1

    See identical proteins and their annotated locations for NP_066306.2

    Status: VALIDATED

    Source sequence(s)
    AC000041, CR456562
    Consensus CDS
    CCDS13857.2
    UniProtKB/Swiss-Prot
    O75677
    Related
    ENSP00000346342.2, ENST00000354373.2
    Conserved Domains (3) summary
    pfam11002
    Location:83124
    RDM; RFPL defining motif (RDM)
    pfam15227
    Location:4081
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15821
    Location:122299
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    29403031..29442490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028902.2XP_016884391.1  ret finger protein-like 1 isoform X1

    UniProtKB/Swiss-Prot
    O75677
    Conserved Domains (3) summary
    pfam11002
    Location:5495
    RDM; RFPL defining motif (RDM)
    pfam15227
    Location:1152
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15821
    Location:93270
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
  2. XM_011530298.3XP_011528600.1  ret finger protein-like 1 isoform X1

    See identical proteins and their annotated locations for XP_011528600.1

    UniProtKB/Swiss-Prot
    O75677
    Conserved Domains (3) summary
    pfam11002
    Location:5495
    RDM; RFPL defining motif (RDM)
    pfam15227
    Location:1152
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15821
    Location:93270
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
  3. XM_017028900.2XP_016884389.1  ret finger protein-like 1 isoform X1

    UniProtKB/Swiss-Prot
    O75677
    Conserved Domains (3) summary
    pfam11002
    Location:5495
    RDM; RFPL defining motif (RDM)
    pfam15227
    Location:1152
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15821
    Location:93270
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
  4. XM_011530299.3XP_011528601.1  ret finger protein-like 1 isoform X1

    See identical proteins and their annotated locations for XP_011528601.1

    UniProtKB/Swiss-Prot
    O75677
    Conserved Domains (3) summary
    pfam11002
    Location:5495
    RDM; RFPL defining motif (RDM)
    pfam15227
    Location:1152
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15821
    Location:93270
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
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