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REG1A regenerating family member 1 alpha [ Homo sapiens (human) ]

Gene ID: 5967, updated on 28-Jun-2021

Summary

Official Symbol
REG1Aprovided by HGNC
Official Full Name
regenerating family member 1 alphaprovided by HGNC
Primary source
HGNC:HGNC:9951
See related
Ensembl:ENSG00000115386 MIM:167770
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P19; PSP; PTP; REG; ICRF; PSPS; PSPS1
Summary
This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]
Expression
Biased expression in pancreas (RPKM 5037.4), duodenum (RPKM 2788.3) and 2 other tissues See more
Orthologs
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Genomic context

See REG1A in Genome Data Viewer
Location:
2p12
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (79120488..79123409)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (79347614..79350535)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene regenerating family member 3 gamma Neighboring gene regenerating family member 1 beta Neighboring gene regenerating family member 1 gamma, pseudogene Neighboring gene regenerating family member 3 alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12447

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables oligosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptidoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell wall disruption in other organism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to chemokine IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to gastrin IEA
Inferred from Electronic Annotation
more info
 
involved_in liver regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in midgut development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in pancreas regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of acinar cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of dendrite extension IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of type B pancreatic cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to acetylsalicylate IEA
Inferred from Electronic Annotation
more info
 
involved_in response to growth hormone-releasing hormone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 
involved_in response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to water-immersion restraint stress IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in wound healing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in basal part of cell IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
located_in zymogen granule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lithostathine-1-alpha
Names
REG-1-alpha
islet cells regeneration factor
islet of langerhans regenerating protein
pancreatic stone protein, secretory
pancreatic thread protein
protein-X
regenerating islet-derived protein 1-alpha
regenerating protein I alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023271.1 RefSeqGene

    Range
    5031..7952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002909.5NP_002900.2  lithostathine-1-alpha precursor

    See identical proteins and their annotated locations for NP_002900.2

    Status: REVIEWED

    Source sequence(s)
    AK291981, AW873911, BM769434, W38384
    Consensus CDS
    CCDS1964.1
    UniProtKB/Swiss-Prot
    P05451
    UniProtKB/TrEMBL
    A8K7G6
    Related
    ENSP00000233735.1, ENST00000233735.2
    Conserved Domains (1) summary
    cl02432
    Location:36164
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    79120488..79123409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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