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REG1A regenerating family member 1 alpha [ Homo sapiens (human) ]

Gene ID: 5967, updated on 11-Sep-2019

Summary

Official Symbol
REG1Aprovided by HGNC
Official Full Name
regenerating family member 1 alphaprovided by HGNC
Primary source
HGNC:HGNC:9951
See related
Ensembl:ENSG00000115386 MIM:167770
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P19; PSP; PTP; REG; ICRF; PSPS; PSPS1
Summary
This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]
Expression
Biased expression in pancreas (RPKM 5037.4), duodenum (RPKM 2788.3) and 2 other tissues See more
Orthologs

Genomic context

See REG1A in Genome Data Viewer
Location:
2p12
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (79120488..79123409)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (79347584..79350545)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene regenerating family member 3 gamma Neighboring gene regenerating family member 1 beta Neighboring gene regenerating family member 1 gamma, pseudogene Neighboring gene regenerating family member 3 alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.
NHGRI GWA Catalog

Pathways from BioSystems

  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
    Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12447

Gene Ontology Provided by GOA

Function Evidence Code Pubs
growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
oligosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
cell wall disruption in other organism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to chemokine IEA
Inferred from Electronic Annotation
more info
 
cellular response to gastrin IEA
Inferred from Electronic Annotation
more info
 
liver regeneration IEA
Inferred from Electronic Annotation
more info
 
midgut development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
pancreas regeneration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of acinar cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of dendrite extension IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of type B pancreatic cell proliferation IEA
Inferred from Electronic Annotation
more info
 
protein homotetramerization IEA
Inferred from Electronic Annotation
more info
 
response to acetylsalicylate IEA
Inferred from Electronic Annotation
more info
 
response to growth hormone-releasing hormone IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 
response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to water-immersion restraint stress IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
wound healing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basal part of cell IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
dendrite membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth cone IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
zymogen granule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lithostathine-1-alpha
Names
REG-1-alpha
islet cells regeneration factor
islet of langerhans regenerating protein
pancreatic stone protein, secretory
pancreatic thread protein
protein-X
regenerating islet-derived protein 1-alpha
regenerating protein I alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023271.1 RefSeqGene

    Range
    5031..7952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002909.5NP_002900.2  lithostathine-1-alpha precursor

    See identical proteins and their annotated locations for NP_002900.2

    Status: REVIEWED

    Source sequence(s)
    AK291981, AW873911, BM769434, W38384
    Consensus CDS
    CCDS1964.1
    UniProtKB/Swiss-Prot
    P05451
    UniProtKB/TrEMBL
    A8K7G6
    Related
    ENSP00000233735.1, ENST00000233735.2
    Conserved Domains (1) summary
    cl02432
    Location:36164
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    79120488..79123409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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