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RCVRN recoverin [ Homo sapiens (human) ]

Gene ID: 5957, updated on 18-Aug-2020

Summary

Official Symbol
RCVRNprovided by HGNC
Official Full Name
recoverinprovided by HGNC
Primary source
HGNC:HGNC:9937
See related
Ensembl:ENSG00000109047 MIM:179618
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RCV1
Summary
This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See RCVRN in Genome Data Viewer
Location:
17p13.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (9896320..9905271, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (9801027..9808684, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene GSG1 like 2 Neighboring gene glucagon like peptide 2 receptor Neighboring gene nucleophosmin 1 pseudogene 45 Neighboring gene growth arrest specific 7 Neighboring gene RPS27A pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium sensitive guanylate cyclase activator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
phototransduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
dendrite IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
 
photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
recoverin
Names
cancer associated retinopathy antigen
cancer-associated retinopathy protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002903.3NP_002894.1  recoverin

    See identical proteins and their annotated locations for NP_002894.1

    Status: REVIEWED

    Source sequence(s)
    AC026591, BC001720, S43855
    Consensus CDS
    CCDS11151.1
    UniProtKB/Swiss-Prot
    P35243
    Related
    ENSP00000226193.5, ENST00000226193.6
    Conserved Domains (1) summary
    COG5126
    Location:14182
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    9896320..9905271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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