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SIGIRR single Ig and TIR domain containing [ Homo sapiens (human) ]

Gene ID: 59307, updated on 13-Mar-2020

Summary

Official Symbol
SIGIRRprovided by HGNC
Official Full Name
single Ig and TIR domain containingprovided by HGNC
Primary source
HGNC:HGNC:30575
See related
Ensembl:ENSG00000185187 MIM:605478
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIR8; IL-1R8
Expression
Ubiquitous expression in spleen (RPKM 19.3), kidney (RPKM 16.8) and 25 other tissues See more
Orthologs

Genomic context

See SIGIRR in Genome Data Viewer
Location:
11p15.5
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (405716..417454, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (405716..417454, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene beta-1,4-N-acetyl-galactosaminyltransferase 4 Neighboring gene plakophilin 3 Neighboring gene anoctamin 9 Neighboring gene uncharacterized LOC105376506 Neighboring gene RNA, 7SL, cytoplasmic 838, pseudogene Neighboring gene phosphatidylserine synthase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC110992

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acute-phase response ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to cytokine stimulus TAS
Traceable Author Statement
more info
 
negative regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of chemokine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cytokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of lipopolysaccharide-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
single Ig IL-1-related receptor
Names
interleukin-1 receptor 8 long isoform
single Ig IL-1R-related molecule
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
single immunoglobulin domain IL1R1 related
single immunoglobulin domain-containing IL1R-related protein
toll/interleukin-1 receptor 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135053.2NP_001128525.1  single Ig IL-1-related receptor

    See identical proteins and their annotated locations for NP_001128525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK025099, AK172830, BX369506, DA963481
    Consensus CDS
    CCDS31325.1
    UniProtKB/Swiss-Prot
    Q6IA17
    Related
    ENSP00000380756.3, ENST00000397632.7
    Conserved Domains (2) summary
    pfam01582
    Location:165311
    TIR; TIR domain
    cl11960
    Location:8111
    Ig; Immunoglobulin domain
  2. NM_001135054.2NP_001128526.1  single Ig IL-1-related receptor

    See identical proteins and their annotated locations for NP_001128526.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AK025099, AK172830, BX369506, DB112269
    Consensus CDS
    CCDS31325.1
    UniProtKB/Swiss-Prot
    Q6IA17
    Related
    ENSP00000403104.2, ENST00000431843.7
    Conserved Domains (2) summary
    pfam01582
    Location:165311
    TIR; TIR domain
    cl11960
    Location:8111
    Ig; Immunoglobulin domain
  3. NM_021805.3NP_068577.2  single Ig IL-1-related receptor

    See identical proteins and their annotated locations for NP_068577.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK025099, AK172830, BX369506
    Consensus CDS
    CCDS31325.1
    UniProtKB/Swiss-Prot
    Q6IA17
    Related
    ENSP00000333656.3, ENST00000332725.7
    Conserved Domains (2) summary
    pfam01582
    Location:165311
    TIR; TIR domain
    cl11960
    Location:8111
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    405716..417454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253046.1XP_005253103.1  single Ig IL-1-related receptor isoform X1

    See identical proteins and their annotated locations for XP_005253103.1

    UniProtKB/TrEMBL
    C9JFX4
    Conserved Domains (2) summary
    pfam01582
    Location:165311
    TIR; TIR domain
    cl11960
    Location:8111
    Ig; Immunoglobulin domain
  2. XM_005253045.1XP_005253102.1  single Ig IL-1-related receptor isoform X1

    See identical proteins and their annotated locations for XP_005253102.1

    UniProtKB/TrEMBL
    C9JFX4
    Related
    ENSP00000433022.1, ENST00000531205.5
    Conserved Domains (2) summary
    pfam01582
    Location:165311
    TIR; TIR domain
    cl11960
    Location:8111
    Ig; Immunoglobulin domain
  3. XM_005253048.4XP_005253105.1  single Ig IL-1-related receptor isoform X3

    Conserved Domains (1) summary
    pfam01582
    Location:110256
    TIR; TIR domain
  4. XM_017018100.2XP_016873589.1  single Ig IL-1-related receptor isoform X4

  5. XM_017018099.2XP_016873588.1  single Ig IL-1-related receptor isoform X2

    Conserved Domains (2) summary
    pfam01582
    Location:165311
    TIR; TIR domain
    cl11960
    Location:8111
    Ig; Immunoglobulin domain
  6. XM_005253044.3XP_005253101.1  single Ig IL-1-related receptor isoform X1

    See identical proteins and their annotated locations for XP_005253101.1

    UniProtKB/TrEMBL
    C9JFX4
    Conserved Domains (2) summary
    pfam01582
    Location:165311
    TIR; TIR domain
    cl11960
    Location:8111
    Ig; Immunoglobulin domain

RNA

  1. XR_001747933.2 RNA Sequence

  2. XR_001747934.2 RNA Sequence

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