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UBL5 ubiquitin like 5 [ Homo sapiens (human) ]

Gene ID: 59286, updated on 8-Dec-2018

Summary

Official Symbol
UBL5provided by HGNC
Official Full Name
ubiquitin like 5provided by HGNC
Primary source
HGNC:HGNC:13736
See related
Ensembl:ENSG00000198258 MIM:606849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HUB1
Summary
This gene encodes a member of a group of proteins similar to ubiquitin. The encoded protein is not thought to degrade proteins like ubiquitin but to affect their function through being bound to target proteins by an isopeptide bond. The gene product has been studied as a link to predisposition to obesity based on its expression in Psammomys obesus, the fat sand rat, which is an animal model for obesity studies. Variation in this gene was found to be significantly associated with some metabolic traits (PMID: 15331561) but not associated with childhood obesity (PMID: 19189687). Pseudogenes of this gene are located on chromosomes 3, 5 and 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in kidney (RPKM 86.7), adrenal (RPKM 83.4) and 25 other tissues See more
Orthologs

Genomic context

See UBL5 in Genome Data Viewer
Location:
19p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (9827880..9830121)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9938556..9940797)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100505555 Neighboring gene F-box and leucine rich repeat protein 12 Neighboring gene ribosomal protein L10 pseudogene 15 Neighboring gene uncharacterized LOC100996288 Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ46917, MGC131795

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tag IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular protein modification process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein targeting to mitochondrion HMP PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin-like protein 5
Names
beacon
testicular tissue protein Li 217

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048241.2NP_001041706.1  ubiquitin-like protein 5

    See identical proteins and their annotated locations for NP_001041706.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AV682189, BC110839, BP213482, CA418471
    Consensus CDS
    CCDS12219.1
    UniProtKB/Swiss-Prot
    Q9BZL1
    UniProtKB/TrEMBL
    A0A024R7B0
    Related
    ENSP00000468656.1, ENST00000586895.5
    Conserved Domains (1) summary
    cd01791
    Location:173
    Ubl5; UBL5 ubiquitin-like modifier
  2. NM_024292.3NP_077268.1  ubiquitin-like protein 5

    See identical proteins and their annotated locations for NP_077268.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK128885, BC007053, CA418471
    Consensus CDS
    CCDS12219.1
    UniProtKB/Swiss-Prot
    Q9BZL1
    UniProtKB/TrEMBL
    A0A024R7B0
    Related
    ENSP00000351492.2, ENST00000358666.7
    Conserved Domains (1) summary
    cd01791
    Location:173
    Ubl5; UBL5 ubiquitin-like modifier

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    9827880..9830121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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