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EVA1C eva-1 homolog C [ Homo sapiens (human) ]

Gene ID: 59271, updated on 13-Mar-2020

Summary

Official Symbol
EVA1Cprovided by HGNC
Official Full Name
eva-1 homolog Cprovided by HGNC
Primary source
HGNC:HGNC:13239
See related
Ensembl:ENSG00000166979
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B18; B19; SUE21; PRED34; FAM176C; C21orf63; C21orf64
Expression
Ubiquitous expression in prostate (RPKM 3.9), gall bladder (RPKM 3.7) and 25 other tissues See more
Orthologs

Genomic context

See EVA1C in Genome Data Viewer
Location:
21q22.11
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (32411692..32515387)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (33784034..33887702)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene URB1 ribosome biogenesis homolog Neighboring gene Sharpr-MPRA regulatory region 9918 Neighboring gene small nucleolar RNA, H/ACA box 80A Neighboring gene URB1 antisense RNA 1 (head to head) Neighboring gene histone demethylase UTY-like Neighboring gene exosome component 3 pseudogene 1 Neighboring gene CFAP298-TCP10L readthrough Neighboring gene RNA, 5S ribosomal pseudogene 490 Neighboring gene t-complex 10 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heparin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
colocalizes_with extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein eva-1 homolog C
Names
family with sequence similarity 176, member C
protein FAM176C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286556.2NP_001273485.1  protein eva-1 homolog C isoform 2 precursor

    See identical proteins and their annotated locations for NP_001273485.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame donor splice site in the 3' coding region compared to variant 1. The resulting shorter isoform (2) lacks a 3 aa segment compared to isoform 1.
    Source sequence(s)
    AY358787, BC038710, BU175692
    Consensus CDS
    CCDS68186.1
    UniProtKB/Swiss-Prot
    P58658
    Related
    ENSP00000372146.3, ENST00000382699.7
    Conserved Domains (2) summary
    pfam02140
    Location:75158
    Gal_Lectin; Galactose binding lectin domain
    pfam14851
    Location:298438
    FAM176; FAM176 family
  2. NM_001320744.2NP_001307673.1  protein eva-1 homolog C isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate, in-frame exons in the 5' coding region compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AP000269, AP000270, AP000271, AP000272
    Conserved Domains (2) summary
    pfam02140
    Location:69152
    Gal_Lectin; Galactose binding lectin domain
    pfam14851
    Location:194334
    FAM176; FAM176 family
  3. NM_001320745.2NP_001307674.1  protein eva-1 homolog C isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate 5' -terminal exon, which results in a different 5' UTR and use of a downstream start AUG compared to variant 1. It encodes isoform 4, which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AP000269, AW957938, BM836911, CA412371
    UniProtKB/TrEMBL
    B3KWG0
    Conserved Domains (2) summary
    pfam02140
    Location:81164
    Gal_Lectin; Galactose binding lectin domain
    pfam14851
    Location:206346
    FAM176; FAM176 family
  4. NM_058187.5NP_478067.2  protein eva-1 homolog C isoform 1 precursor

    See identical proteins and their annotated locations for NP_478067.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1).
    Source sequence(s)
    AY358787, BC038710, BU175692
    Consensus CDS
    CCDS13614.1
    UniProtKB/Swiss-Prot
    P58658
    Related
    ENSP00000300255.2, ENST00000300255.7
    Conserved Domains (2) summary
    pfam02140
    Location:75158
    Gal_Lectin; Galactose binding lectin domain
    pfam14851
    Location:301441
    FAM176; FAM176 family

RNA

  1. NR_104472.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY040087, AY358787, BC038710, BU175692
    Related
    ENST00000437338.5
  2. NR_135467.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site at an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP000269, AP000272, BM836911, BX342316, CA412371

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    32411692..32515387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028421.1XP_016883910.1  protein eva-1 homolog C isoform X7

  2. XM_024452125.1XP_024307893.1  protein eva-1 homolog C isoform X6

    Conserved Domains (2) summary
    pfam02140
    Location:80163
    Gal_Lectin; Galactose binding lectin domain
    pfam14851
    Location:205345
    FAM176; FAM176 family
  3. XM_024452126.1XP_024307894.1  protein eva-1 homolog C isoform X8

    Conserved Domains (2) summary
    pfam02140
    Location:80163
    Gal_Lectin; Galactose binding lectin domain
    pfam14851
    Location:202342
    FAM176; FAM176 family
  4. XM_017028420.1XP_016883909.1  protein eva-1 homolog C isoform X5

    UniProtKB/TrEMBL
    B3KWG0
    Conserved Domains (2) summary
    pfam02140
    Location:81164
    Gal_Lectin; Galactose binding lectin domain
    pfam14851
    Location:206346
    FAM176; FAM176 family
  5. XM_017028419.1XP_016883908.1  protein eva-1 homolog C isoform X3

  6. XM_005261019.4XP_005261076.1  protein eva-1 homolog C isoform X4

    Conserved Domains (2) summary
    pfam02140
    Location:75158
    Gal_Lectin; Galactose binding lectin domain
    pfam14851
    Location:254384
    FAM176; FAM176 family
  7. XM_006724038.3XP_006724101.1  protein eva-1 homolog C isoform X2

    Conserved Domains (2) summary
    pfam02140
    Location:75158
    Gal_Lectin; Galactose binding lectin domain
    pfam14851
    Location:300440
    FAM176; FAM176 family
  8. XM_017028418.1XP_016883907.1  protein eva-1 homolog C isoform X1

  9. XM_017028422.1XP_016883911.1  protein eva-1 homolog C isoform X9

  10. XM_017028423.1XP_016883912.1  protein eva-1 homolog C isoform X10

  11. XM_011529669.3XP_011527971.1  protein eva-1 homolog C isoform X5

    See identical proteins and their annotated locations for XP_011527971.1

    UniProtKB/TrEMBL
    B3KWG0
    Conserved Domains (2) summary
    pfam02140
    Location:81164
    Gal_Lectin; Galactose binding lectin domain
    pfam14851
    Location:206346
    FAM176; FAM176 family

RNA

  1. XR_001754885.1 RNA Sequence

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