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Tpm3 tropomyosin 3, gamma [ Mus musculus (house mouse) ]

Gene ID: 59069, updated on 5-Mar-2024

Summary

Official Symbol
Tpm3provided by MGI
Official Full Name
tropomyosin 3, gammaprovided by MGI
Primary source
MGI:MGI:1890149
See related
Ensembl:ENSMUSG00000027940 AllianceGenome:MGI:1890149
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TMnm; Tpm5; Tm5NM; Tpm-5; hTMnm; TM30nm; Trop-5; hTM30nm; gamma-TM
Summary
Enables actin filament binding activity. Predicted to be involved in actin filament organization and muscle contraction. Located in cleavage furrow; cytoskeleton; and growth cone. Is expressed in coelomic epithelium of testis; ovary; and primary sex cord. Human ortholog(s) of this gene implicated in congenital fiber-type disproportion and nemaline myopathy 1. Orthologous to human TPM3 (tropomyosin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 17.7), CNS E11.5 (RPKM 17.1) and 28 other tissues See more
Orthologs
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Genomic context

See Tpm3 in Genome Data Viewer
Location:
3 F1; 3 39.2 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89979958..90008209)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90072651..90100902)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 141 Neighboring gene STARR-seq mESC enhancer starr_08271 Neighboring gene STARR-positive B cell enhancer ABC_E3447 Neighboring gene STARR-positive B cell enhancer ABC_E7923 Neighboring gene microRNA 190b Neighboring gene STARR-seq mESC enhancer starr_08272 Neighboring gene nucleoporin 210-like Neighboring gene predicted gene, 34865 Neighboring gene predicted gene, 23723 Neighboring gene STARR-seq mESC enhancer starr_08276 Neighboring gene predicted gene, 24185

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102590

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
located_in cortical cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in podosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
tropomyosin alpha-3 chain
Names
gamma-tropomyosin
skalphaTM.2
tropomyosin 5
tropomyosin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253738.1NP_001240667.1  tropomyosin alpha-3 chain isoform Tpm3.1cy

    See identical proteins and their annotated locations for NP_001240667.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3, also known as variant Tpm3.1) represents the use of an alternate promoter and differs in the 5' structure, causing translation initiation at an alternate start codon compared to variant Tpm3.13. The encoded isoform (Tpm3.1cy, also known as isoform 3) has a distinct N-terminus and is shorter than isoform Tpm3.13cy. Isoforms Tpm3.1cy, Tpm3.2cy, and Tpm3.5cy are the same length, but contain distinct C-termini.
    Source sequence(s)
    AK146557, BY284672, BY622941
    Consensus CDS
    CCDS57223.1
    UniProtKB/TrEMBL
    D3Z2H9, Q58E70
    Related
    ENSMUSP00000029549.9, ENSMUST00000029549.16
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin; Tropomyosin
  2. NM_001253740.1NP_001240669.1  tropomyosin alpha-3 chain isoform Tpm3.2cy

    See identical proteins and their annotated locations for NP_001240669.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4, also known as variant Tpm3.2) represents the use of an alternate promoter and has multiple differences compared to variant Tpm3.13. These differences result in a different 5' UTR and cause translation initiation at an alternate start codon compared to variant Tpm3.13. The encoded isoform (Tpm3.2cy, also known as isoform 4) has a distinct N-terminus and is shorter than isoform Tpm3.13cy. Isoforms Tpm3.1cy, Tpm3.2cy, and Tpm3.5cy are the same length, but contain distinct C-termini.
    Source sequence(s)
    AK146557, BY284672, BY622941, CX237327
    UniProtKB/TrEMBL
    Q58E70
    Conserved Domains (2) summary
    pfam00261
    Location:12246
    Tropomyosin; Tropomyosin
    pfam06009
    Location:150229
    Laminin_II; Laminin Domain II
  3. NM_001271764.2NP_001258693.1  tropomyosin alpha-3 chain isoform Tpm3.5cy

    See identical proteins and their annotated locations for NP_001258693.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5, also known as variant Tpm3.5) represents the use of an alternate promoter and has multiple differences compared to variant Tpm3.13. These differences result in different 5' and 3' UTRs and cause translation initiation at an alternate start codon compared to variant Tpm3.13. The encoded isoform (Tpm3.5cy, also known as isoform 5) has distinct N- and C- termini and is shorter than isoform Tpm3.13cy. Isoforms Tpm3.1cy, Tpm3.2cy, and Tpm3.5cy are the same length, but contain distinct C-termini.
    Source sequence(s)
    AI842950, AK050665, BB690682, BY284672
    UniProtKB/TrEMBL
    Q8C7C3
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin
  4. NM_001293748.1NP_001280677.2  tropomyosin alpha-3 chain isoform Tpm3.12st

    See identical proteins and their annotated locations for NP_001280677.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as variant Tpm3.12) differs in the 3' UTR and has multiple differences in the 3' coding region compared to variant Tpm3.13. The encoded isoform (Tpm3.12st, also known as isoform 2) is the same length as isoform Tpm3.13cy, but contains a distinct C-terminal segment. The encoded protein is the fast skeletal muscle isoform.
    Source sequence(s)
    AC163616
    UniProtKB/Swiss-Prot
    P21107, Q09021, Q60606, Q80SW6, Q9EPW3
    Related
    ENSMUSP00000113578.2, ENSMUST00000121503.8
    Conserved Domains (2) summary
    pfam00261
    Location:49283
    Tropomyosin
    pfam16526
    Location:1473
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
  5. NM_001293749.1NP_001280678.1  tropomyosin alpha-3 chain isoform Tpm3.4cy

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6, also known as variant Tpm3.4) represents the use of an alternate promoter, differs in the 5' and 3' structures and has multiple differences in the coding region compared to variant Tpm3.13. These differences cause translation initiation at an alternate start codon compared to variant Tpm3.13. The encoded isoform (Tpm3.4cy, also known as isoform 6) has distinct N- and C- termini and is shorter than isoform Tpm3.13cy.
    Source sequence(s)
    AC163616, BF464045
    Consensus CDS
    CCDS79961.1
    UniProtKB/TrEMBL
    D3Z6I8
    Related
    ENSMUSP00000113219.2, ENSMUST00000119158.8
    Conserved Domains (1) summary
    pfam00261
    Location:12245
    Tropomyosin; Tropomyosin
  6. NM_001357581.1NP_001344510.1  tropomyosin alpha-3 chain isoform Tpm3.3cy

    Status: VALIDATED

    Source sequence(s)
    AC163616, AI842950
    Consensus CDS
    CCDS89659.1
    UniProtKB/TrEMBL
    E9Q7Q3
    Related
    ENSMUSP00000113056.2, ENSMUST00000118566.8
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin
  7. NM_022314.3NP_071709.3  tropomyosin alpha-3 chain isoform Tpm3.13cy

    See identical proteins and their annotated locations for NP_071709.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as variant Tpm3.13) encodes isoform Tpm3.13cy (also known as isoform 1). This isoform is the same length as isoform Tpm3.12st, but contains a distinct C-terminal segment.
    Source sequence(s)
    AK146557, BC029186, BY622941, BY770803
    Consensus CDS
    CCDS38499.2
    UniProtKB/TrEMBL
    E9Q5J9
    Related
    ENSMUSP00000113978.2, ENSMUST00000119570.8
    Conserved Domains (1) summary
    pfam00261
    Location:49283
    Tropomyosin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89979958..90008209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501839.4XP_006501902.1  tropomyosin alpha-3 chain isoform X6

    Conserved Domains (1) summary
    pfam00261
    Location:12245
    Tropomyosin
  2. XM_006501835.2XP_006501898.1  tropomyosin alpha-3 chain isoform X1

    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin
  3. XM_006501836.2XP_006501899.1  tropomyosin alpha-3 chain isoform X2

    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin
  4. XM_017319677.3XP_017175166.1  tropomyosin alpha-3 chain isoform X3

    UniProtKB/TrEMBL
    Q8C7C3
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin
  5. XM_036163205.1XP_036019098.1  tropomyosin alpha-3 chain isoform X5

    UniProtKB/TrEMBL
    E9Q7Q3
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin
  6. XM_030252742.1XP_030108602.1  tropomyosin alpha-3 chain isoform X4

    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin
  7. XM_006501841.3XP_006501904.1  tropomyosin alpha-3 chain isoform X7

    Conserved Domains (1) summary
    pfam00261
    Location:23180
    Tropomyosin

RNA

  1. XR_004941375.1 RNA Sequence