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Rnf130 ring finger protein 130 [ Mus musculus (house mouse) ]

Gene ID: 59044, updated on 2-Nov-2024

Summary

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Official Symbol
Rnf130provided by MGI
Official Full Name
ring finger protein 130provided by MGI
Primary source
MGI:MGI:1891717
See related
Ensembl:ENSMUSG00000020376 AllianceGenome:MGI:1891717
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GP; G1rp; G1RZFP; GOLIATH; 2510042A13Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Involved in programmed cell death. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; male reproductive system; retina; and urinary system. Orthologous to human RNF130 (ring finger protein 130). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 19.6), whole brain E14.5 (RPKM 16.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf130 in Genome Data Viewer
Location:
11 B1.3; 11 30.16 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (49916158..50016546)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50025331..50125719)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5221 Neighboring gene mitogen-activated protein kinase 9 Neighboring gene predicted gene, 53699 Neighboring gene RasGEF domain family, member 1C Neighboring gene microRNA 340 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene TBC1 domain family, member 9B Neighboring gene predicted gene, 53700

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Goliath induces inflammation in obese mice by linking fatty acid β-oxidation to glycolysis. Hao S, et al. EMBO Rep, 2023 Apr 5. PMID 36862324, Free PMC Article
  2. RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol Levels. Clifford BL, et al. Circ Res, 2023 Mar 31. PMID 36876496, Free PMC Article
  3. Cloning of murine G1RP, a novel gene related to Drosophila melanogaster g1. Baker SJ, et al. Gene, 2000 May 2. PMID 10806348
  4. RNF130 protects against pulmonary fibrosis through suppressing aerobic glycolysis by mediating c-myc ubiquitination. Zhang J, et al. Int Immunopharmacol, 2023 Apr. PMID 36893517
  5. The E3 ubiquitin ligase GREUL1 anteriorizes ectoderm during Xenopus development. Borchers AG, et al. Dev Biol, 2002 Nov 15. PMID 12435366

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF130 protects against pulmonary fibrosis through suppressing aerobic glycolysis by mediating c-myc ubiquitination.
    Title: RNF130 protects against pulmonary fibrosis through suppressing aerobic glycolysis by mediating c-myc ubiquitination.
  2. Goliath induces inflammation in obese mice by linking fatty acid beta-oxidation to glycolysis.
    Title: Goliath induces inflammation in obese mice by linking fatty acid β-oxidation to glycolysis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 2510042A13Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF130
Names
RING-type E3 ubiquitin transferase RNF130
g1-related zinc finger protein
goliath homolog
NP_001277678.1
NP_001277679.1
NP_067515.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290749.1 → NP_001277678.1  E3 ubiquitin-protein ligase RNF130 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AI852677, AL645913, BC048901
    Consensus CDS
    CCDS78937.1
    UniProtKB/TrEMBL
    Q5SVR5
    Related
    ENSMUSP00000056345.8, ENSMUST00000054684.14
    Conserved Domains (3) summary
    COG5243
    Location:197 → 306
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd02122
    Location:40 → 179
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    cd16803
    Location:262 → 310
    RING-H2_RNF130; RING finger, H2 subclass, found in RING finger protein 130 (RNF130) and similar proteins

  2. NM_001290750.1 → NP_001277679.1  E3 ubiquitin-protein ligase RNF130 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (3) is the same length but has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL627187, AL645913, BC048901, CB246244
    Consensus CDS
    CCDS88150.1
    UniProtKB/TrEMBL
    A0A571BES6
    Related
    ENSMUSP00000158797.2, ENSMUST00000238748.2
    Conserved Domains (3) summary
    COG5243
    Location:197 → 306
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd02122
    Location:40 → 179
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    cd16803
    Location:262 → 310
    RING-H2_RNF130; RING finger, H2 subclass, found in RING finger protein 130 (RNF130) and similar proteins

  3. NM_021540.4 → NP_067515.2  E3 ubiquitin-protein ligase RNF130 isoform 1 precursor

    See identical proteins and their annotated locations for NP_067515.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AI852677, AL645913, BC048901
    Consensus CDS
    CCDS24626.1
    UniProtKB/Swiss-Prot
    Q80VL7, Q8VEM1, Q9QZQ6
    Related
    ENSMUSP00000099837.5, ENSMUST00000102776.5
    Conserved Domains (3) summary
    COG5243
    Location:197 → 306
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd02122
    Location:40 → 179
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    cd16803
    Location:262 → 310
    RING-H2_RNF130; RING finger, H2 subclass, found in RING finger protein 130 (RNF130) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    49916158..50016546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VEM1.1 GenPept UniProtKB/Swiss-Prot:Q8VEM1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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