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Rnf130 ring finger protein 130 [ Mus musculus (house mouse) ]

Gene ID: 59044, updated on 14-May-2024

Summary

Official Symbol
Rnf130provided by MGI
Official Full Name
ring finger protein 130provided by MGI
Primary source
MGI:MGI:1891717
See related
Ensembl:ENSMUSG00000020376 AllianceGenome:MGI:1891717
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GP; G1rp; G1RZFP; GOLIATH; 2510042A13Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Involved in programmed cell death. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human RNF130 (ring finger protein 130). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 19.6), whole brain E14.5 (RPKM 16.1) and 28 other tissues See more
Orthologs
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Genomic context

See Rnf130 in Genome Data Viewer
Location:
11 B1.3; 11 30.16 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (49916158..50016546)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50025331..50125719)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5221 Neighboring gene mitogen-activated protein kinase 9 Neighboring gene predicted gene, 53699 Neighboring gene RasGEF domain family, member 1C Neighboring gene microRNA 340 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene TBC1 domain family, member 9B Neighboring gene predicted gene, 53700

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • 2510042A13Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF130
Names
RING-type E3 ubiquitin transferase RNF130
g1-related zinc finger protein
goliath homolog
NP_001277678.1
NP_001277679.1
NP_067515.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290749.1NP_001277678.1  E3 ubiquitin-protein ligase RNF130 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AI852677, AL645913, BC048901
    Consensus CDS
    CCDS78937.1
    UniProtKB/TrEMBL
    Q5SVR5
    Related
    ENSMUSP00000056345.8, ENSMUST00000054684.14
    Conserved Domains (3) summary
    COG5243
    Location:197306
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd02122
    Location:40179
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    cd16803
    Location:262310
    RING-H2_RNF130; RING finger, H2 subclass, found in RING finger protein 130 (RNF130) and similar proteins
  2. NM_001290750.1NP_001277679.1  E3 ubiquitin-protein ligase RNF130 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (3) is the same length but has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL627187, AL645913, BC048901, CB246244
    Consensus CDS
    CCDS88150.1
    UniProtKB/TrEMBL
    A0A571BES6
    Related
    ENSMUSP00000158797.2, ENSMUST00000238748.2
    Conserved Domains (3) summary
    COG5243
    Location:197306
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd02122
    Location:40179
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    cd16803
    Location:262310
    RING-H2_RNF130; RING finger, H2 subclass, found in RING finger protein 130 (RNF130) and similar proteins
  3. NM_021540.4NP_067515.2  E3 ubiquitin-protein ligase RNF130 isoform 1 precursor

    See identical proteins and their annotated locations for NP_067515.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AI852677, AL645913, BC048901
    Consensus CDS
    CCDS24626.1
    UniProtKB/Swiss-Prot
    Q80VL7, Q8VEM1, Q9QZQ6
    Related
    ENSMUSP00000099837.5, ENSMUST00000102776.5
    Conserved Domains (3) summary
    COG5243
    Location:197306
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd02122
    Location:40179
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    cd16803
    Location:262310
    RING-H2_RNF130; RING finger, H2 subclass, found in RING finger protein 130 (RNF130) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    49916158..50016546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)