Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp2r3cprovided by MGI
Official Full Name: protein phosphatase 2, regulatory subunit B'', gammaprovided by MGI
Primary source: MGI:MGI:1930009
See related: Ensembl:ENSMUSG00000021022 AllianceGenome:MGI:1930009
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: G4-1; G5pr; 4930511A21Rik; 5730412A08Rik
Summary: Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including lymphocyte homeostasis; positive regulation of B cell differentiation; and spleen development. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in centrosome. Is expressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; and embryo. Human ortholog(s) of this gene implicated in spermatogenic failure 36. Orthologous to human PPP2R3C (protein phosphatase 2 regulatory subunit B''gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 10.4), CNS E14 (RPKM 10.1) and 24 other tissues See more
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Genomic context

Location:: 12 C1; 12 23.9 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (55327594..55350024, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (55280809..55303239, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings suggest that G5PR is involved in both the survival of B cells and the differentiation of peritoneal B1a cells into autoantibody-producing plasma cells.
Title: JNK regulatory molecule G5PR induces IgG autoantibody-producing plasmablasts from peritoneal B1a cells.
G5PR regulates the thymocyte unique apoptotic signal involved in JNK-mediated Caspase-3 activation but not in Bim activation.
Title: Protein phosphatase subunit G5PR that regulates the JNK-mediated apoptosis signal is essential for the survival of CD4 and CD8 double-positive thymocytes.
G5PR is required for the B cell receptor-mediated proliferation associated with the prevention of activation-induced cell death in mature B cells.
Title: Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ppp2r3c (e-PCR), detects polymorphism
- UniSTS:548011

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within B cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within T cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within activation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of B cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of B cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of antimicrobial humoral response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dephosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of mitochondrial depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spleen development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

Names: phosphatase subunit gene g4-1; protein phosphatase subunit G5PR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021529.4 → NP_067504.2 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

See identical proteins and their annotated locations for NP_067504.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the protein-coding transcript.

Source sequence(s)

AC166323

Consensus CDS

CCDS36450.1

UniProtKB/Swiss-Prot

B2RR97, Q9CSA6, Q9JJD2, Q9JK24

Related

ENSMUSP00000021410.9, ENSMUST00000021410.10

Conserved Domains (1) summary

pfam17958
Location:184 → 258

EF-hand_13; EF-hand domain

RNA

NR_168549.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC166323
NR_168550.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC166323
NR_168551.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC166323
NR_168552.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC166323

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

55327594..55350024 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246828.1 → XP_030102688.1 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1

UniProtKB/Swiss-Prot

B2RR97, Q9CSA6, Q9JJD2, Q9JK24

Conserved Domains (1) summary

pfam17958
Location:184 → 258

EF-hand_13; EF-hand domain