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Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma [ Mus musculus (house mouse) ]

Gene ID: 59032, updated on 12-May-2024

Summary

Official Symbol
Ppp2r3cprovided by MGI
Official Full Name
protein phosphatase 2, regulatory subunit B'', gammaprovided by MGI
Primary source
MGI:MGI:1930009
See related
Ensembl:ENSMUSG00000021022 AllianceGenome:MGI:1930009
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G4-1; G5pr; 4930511A21Rik; 5730412A08Rik
Summary
Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including lymphocyte homeostasis; positive regulation of B cell differentiation; and spleen development. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in centrosome. Is expressed in embryo. Human ortholog(s) of this gene implicated in spermatogenic failure 36. Orthologous to human PPP2R3C (protein phosphatase 2 regulatory subunit B''gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 10.4), CNS E14 (RPKM 10.1) and 24 other tissues See more
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Genomic context

See Ppp2r3c in Genome Data Viewer
Location:
12 C1; 12 23.9 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (55327594..55350024, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (55280809..55303239, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 177 member A2 Neighboring gene STARR-positive B cell enhancer mm9_chr12:56329932-56330232 Neighboring gene predicted gene 2446 Neighboring gene signal recognition particle 54C Neighboring gene STARR-positive B cell enhancer ABC_E3052 Neighboring gene STARR-positive B cell enhancer ABC_E3053 Neighboring gene protein only RNase P catalytic subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:56490469-56490652 Neighboring gene STARR-positive B cell enhancer ABC_E8483 Neighboring gene ribosomal protein L18A, pseudogene 1 Neighboring gene proteasome subunit alpha 6 Neighboring gene mitochondrial import inner membrane translocase subunit Tim8 B pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within activation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cortical cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of B cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of antimicrobial humoral response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of mitochondrial depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spleen development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
Names
phosphatase subunit gene g4-1
protein phosphatase subunit G5PR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021529.4NP_067504.2  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

    See identical proteins and their annotated locations for NP_067504.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AC166323
    Consensus CDS
    CCDS36450.1
    UniProtKB/Swiss-Prot
    B2RR97, Q9CSA6, Q9JJD2, Q9JK24
    Related
    ENSMUSP00000021410.9, ENSMUST00000021410.10
    Conserved Domains (1) summary
    pfam17958
    Location:184258
    EF-hand_13; EF-hand domain

RNA

  1. NR_168549.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166323
  2. NR_168550.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166323
  3. NR_168551.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166323
  4. NR_168552.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166323

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    55327594..55350024 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246828.1XP_030102688.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1

    UniProtKB/Swiss-Prot
    B2RR97, Q9CSA6, Q9JJD2, Q9JK24
    Conserved Domains (1) summary
    pfam17958
    Location:184258
    EF-hand_13; EF-hand domain