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Myoz2 myozenin 2 [ Mus musculus (house mouse) ]

Gene ID: 59006, updated on 4-Jun-2024

Summary

Official Symbol
Myoz2provided by MGI
Official Full Name
myozenin 2provided by MGI
Primary source
MGI:MGI:1913063
See related
Ensembl:ENSMUSG00000028116 AllianceGenome:MGI:1913063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fatz-2; Myozl2; 1110012I24Rik
Summary
Enables actin binding activity. Involved in several processes, including negative regulation of calcineurin-NFAT signaling cascade; sarcomere organization; and skeletal muscle fiber adaptation. Located in Z disc and actin cytoskeleton. Is expressed in several structures, including diaphragm; foregut; heart; liver; and skeletal musculature. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 16. Orthologous to human MYOZ2 (myozenin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward heart adult (RPKM 172.8) See more
Orthologs
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Genomic context

See Myoz2 in Genome Data Viewer
Location:
3 G1; 3 53.78 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (122799855..122828649, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (123006206..123035003, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810037I17 gene Neighboring gene STARR-seq mESC enhancer starr_08897 Neighboring gene STARR-positive B cell enhancer ABC_E6116 Neighboring gene STARR-seq mESC enhancer starr_08899 Neighboring gene ubiquitin specific peptidase 53 Neighboring gene STARR-seq mESC enhancer starr_08901 Neighboring gene predicted gene, 54182 Neighboring gene synaptopodin 2 Neighboring gene STARR-seq mESC enhancer starr_08902 Neighboring gene STARR-positive B cell enhancer ABC_E10211 Neighboring gene STARR-seq mESC enhancer starr_08903 Neighboring gene STARR-seq mESC enhancer starr_08904 Neighboring gene SEC24 homolog D, COPII coat complex component

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FATZ binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables telethonin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables telethonin binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin cytoskeleton IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
myozenin-2
Names
FATZ-related protein 2
calsarcin-1
myozenin-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355462.1NP_001342391.1  myozenin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121540
    Conserved Domains (1) summary
    pfam05556
    Location:1235
    Calsarcin; Calcineurin-binding protein (Calsarcin)
  2. NM_021503.2NP_067478.1  myozenin-2 isoform 1

    See identical proteins and their annotated locations for NP_067478.1

    Status: VALIDATED

    Source sequence(s)
    AC121540
    Consensus CDS
    CCDS17816.1
    UniProtKB/Swiss-Prot
    Q9JJW5
    Related
    ENSMUSP00000029761.8, ENSMUST00000029761.14
    Conserved Domains (1) summary
    pfam05556
    Location:1264
    Calsarcin; Calcineurin-binding protein (Calsarcin)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    122799855..122828649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501830.4XP_006501893.1  myozenin-2 isoform X2

    See identical proteins and their annotated locations for XP_006501893.1

    Conserved Domains (1) summary
    pfam05556
    Location:29185
    Calsarcin; Calcineurin-binding protein (Calsarcin)
  2. XM_006501828.4XP_006501891.1  myozenin-2 isoform X1

    See identical proteins and their annotated locations for XP_006501891.1

    Conserved Domains (1) summary
    pfam05556
    Location:1235
    Calsarcin; Calcineurin-binding protein (Calsarcin)