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Pdcd1lg2 programmed cell death 1 ligand 2 [ Mus musculus (house mouse) ]

Gene ID: 58205, updated on 27-Feb-2024

Summary

Official Symbol
Pdcd1lg2provided by MGI
Official Full Name
programmed cell death 1 ligand 2provided by MGI
Primary source
MGI:MGI:1930125
See related
Ensembl:ENSMUSG00000016498 AllianceGenome:MGI:1930125
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Btdc; B7-DC; PD-L2; F730015O22Rik
Summary
Acts upstream of or within negative regulation of T cell proliferation and positive regulation of T cell proliferation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system epithelium; forebrain; nose; retina; and skin. Orthologous to human PDCD1LG2 (programmed cell death 1 ligand 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Pdcd1lg2 in Genome Data Viewer
Location:
19 C1; 19 23.93 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (29388319..29450327)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (29410919..29472927)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52390 Neighboring gene STARR-positive B cell enhancer ABC_E9996 Neighboring gene STARR-positive B cell enhancer ABC_E3250 Neighboring gene STARR-positive B cell enhancer ABC_E5694 Neighboring gene plasminogen receptor, C-terminal lysine transmembrane protein Neighboring gene CD274 antigen Neighboring gene STARR-positive B cell enhancer mm9_chr19:29465786-29466087 Neighboring gene predicted gene, 36043 Neighboring gene STARR-seq mESC enhancer starr_45884 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:29493177-29493330 Neighboring gene STARR-positive B cell enhancer mm9_chr19:29505524-29505825 Neighboring gene STARR-seq mESC enhancer starr_45885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:29528717-29528916 Neighboring gene RIKEN cDNA A930007I19 gene Neighboring gene STARR-positive B cell enhancer ABC_E3251 Neighboring gene STARR-positive B cell enhancer ABC_E8745 Neighboring gene RAB6A GEF complex partner 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC124039, MGC124040

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
programmed cell death 1 ligand 2
Names
PD-1 ligand 2
PDCD1 ligand 2
butyrophilin B7-DC
butyrophilin-like protein
programmed death ligand 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021396.2NP_067371.1  programmed cell death 1 ligand 2 precursor

    See identical proteins and their annotated locations for NP_067371.1

    Status: VALIDATED

    Source sequence(s)
    AC093339, BC104138, BY749628
    Consensus CDS
    CCDS29736.1
    UniProtKB/Swiss-Prot
    Q9WUL5
    UniProtKB/TrEMBL
    Q3U304
    Related
    ENSMUSP00000108195.3, ENSMUST00000112576.4
    Conserved Domains (2) summary
    smart00410
    Location:28119
    IG_like; Immunoglobulin like
    cl11960
    Location:130192
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    29388319..29450327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)