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Sh3kbp1 SH3-domain kinase binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 58194, updated on 31-Jan-2019

Summary

Official Symbol
Sh3kbp1provided by MGI
Official Full Name
SH3-domain kinase binding protein 1provided by MGI
Primary source
MGI:MGI:1889583
See related
Ensembl:ENSMUSG00000040990
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ruk; IN85; Seta; Cin85; AI447724; 1200007H22Rik; 1700125L08Rik; 5830464D22Rik
Expression
Ubiquitous expression in thymus adult (RPKM 11.5), heart adult (RPKM 11.3) and 27 other tissues See more
Orthologs

Genomic context

See Sh3kbp1 in Genome Data Viewer
Location:
X; X F4
Exon count:
27
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (159627028..159975920)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (156065340..156413849)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene Bclaf1 and Thrap3 family member 3 Neighboring gene hepatitis B virus x interacting protein pseudogene Neighboring gene transmembrane protein 126A pseudogene Neighboring gene mitogen-activated protein kinase kinase kinase 15 Neighboring gene cofilin 1, non-muscle pseudogene Neighboring gene predicted gene, 39547 Neighboring gene pyruvate dehydrogenase E1 alpha 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SH3 domain-containing kinase-binding protein 1
Names
Ruk(deltaA) protein
Ruk(h) protein
Ruk(l) protein
Ruk(m1) protein
Ruk(m3) protein
Ruk(t) protein
Ruk(xl) protein
SH3-containing, expressed in tumorigenic astrocytes
regulator of ubiquitous kinase

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135727.2NP_001129199.1  SH3 domain-containing kinase-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001129199.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as Ruk1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI447724, AK028299, AK049182, AK080930, AK142295, BB853873
    Consensus CDS
    CCDS53234.1
    UniProtKB/Swiss-Prot
    Q8R550
    UniProtKB/TrEMBL
    Q3TA88, Q3TT90
    Related
    ENSMUSP00000108075.2, ENSMUST00000112456.8
    Conserved Domains (3) summary
    cd12052
    Location:355
    SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
    cd12055
    Location:102154
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:271326
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
  2. NM_001135728.2NP_001129200.1  SH3 domain-containing kinase-binding protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001129200.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3, also known as Rukm3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AI447724, AK004636, AK028299, AK142295
    Consensus CDS
    CCDS53235.1
    UniProtKB/Swiss-Prot
    Q8R550
    UniProtKB/TrEMBL
    Q3TT90
    Related
    ENSMUSP00000108070.1, ENSMUST00000112451.7
    Conserved Domains (2) summary
    cd12057
    Location:3388
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    cl20817
    Location:365416
    GBP_C; Guanylate-binding protein, C-terminal domain
  3. NM_001290661.1NP_001277590.1  SH3 domain-containing kinase-binding protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001277590.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4, also known as Rukh2) lacks multiple coding exons and contains an alternate 5' exon, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (4) has a shorter N-terminus than isoform 1. Variants 4 and 5 encode the same isoform (4).
    Source sequence(s)
    AI447724, AK028299, AK142295, AK161512
    UniProtKB/Swiss-Prot
    Q8R550
    UniProtKB/TrEMBL
    Q3TT90
    Conserved Domains (1) summary
    cl26721
    Location:2389
    ERG8; Phosphomevalonate kinase [Lipid transport and metabolism]
  4. NM_001290664.1NP_001277593.1  SH3 domain-containing kinase-binding protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001277593.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5, also known as Rukh4) lacks multiple coding exons and contains an alternate 5' exon, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (4) has a shorter N-terminus than isoform 1. Variants 4 and 5 encode the same isoform (4).
    Source sequence(s)
    AI447724, AK028299, AK052260, AK142295, AK161512
    UniProtKB/Swiss-Prot
    Q8R550
    UniProtKB/TrEMBL
    Q3TT90
    Conserved Domains (1) summary
    cl26721
    Location:2389
    ERG8; Phosphomevalonate kinase [Lipid transport and metabolism]
  5. NM_021389.6NP_067364.2  SH3 domain-containing kinase-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_067364.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as RukdeltaA) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AI447724, AK004636, AK028299, AK030839, AK142295
    Consensus CDS
    CCDS41194.1
    UniProtKB/Swiss-Prot
    Q8R550
    UniProtKB/TrEMBL
    Q3TT90
    Related
    ENSMUSP00000079257.6, ENSMUST00000080394.12
    Conserved Domains (2) summary
    cd12055
    Location:65117
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:234289
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

RNA

  1. NR_110969.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs at the 5' end, lacks an internal exon, and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI447724, AK028299, AK030839, AK142295
  2. NR_110970.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs at the 5' end and uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI447724, AK028299, AK030839, AK142295, AL929452
    Related
    ENSMUST00000112447.7

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

    Range
    159627028..159975920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528924.3XP_006528987.1  SH3 domain-containing kinase-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006528987.1

    UniProtKB/Swiss-Prot
    Q8R550
    Conserved Domains (3) summary
    cd12052
    Location:355
    SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
    cd12055
    Location:102154
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:315370
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
  2. XM_006528928.3XP_006528991.1  SH3 domain-containing kinase-binding protein 1 isoform X5

    Conserved Domains (3) summary
    cd12052
    Location:355
    SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
    cd12055
    Location:102154
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:315370
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
  3. XM_017318584.1XP_017174073.1  SH3 domain-containing kinase-binding protein 1 isoform X6

  4. XM_011247849.2XP_011246151.1  SH3 domain-containing kinase-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011246151.1

    UniProtKB/Swiss-Prot
    Q8R550
    Related
    ENSMUSP00000072840.3, ENSMUST00000073094.9
    Conserved Domains (3) summary
    cd12052
    Location:355
    SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
    cd12055
    Location:102154
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:315370
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
  5. XM_017318585.1XP_017174074.1  SH3 domain-containing kinase-binding protein 1 isoform X7

  6. XM_006528926.3XP_006528989.1  SH3 domain-containing kinase-binding protein 1 isoform X3

    Conserved Domains (3) summary
    cd12052
    Location:355
    SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
    cd12055
    Location:102154
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:290345
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
  7. XM_006528925.3XP_006528988.1  SH3 domain-containing kinase-binding protein 1 isoform X2

    Conserved Domains (3) summary
    cd12052
    Location:355
    SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
    cd12055
    Location:102154
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:296351
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
  8. XM_017318586.1XP_017174075.1  SH3 domain-containing kinase-binding protein 1 isoform X9

  9. XM_006528929.3XP_006528992.1  SH3 domain-containing kinase-binding protein 1 isoform X8

    Conserved Domains (2) summary
    cd12055
    Location:4395
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:212267
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
  10. XM_006528927.3XP_006528990.1  SH3 domain-containing kinase-binding protein 1 isoform X4

    Conserved Domains (2) summary
    cd12055
    Location:65117
    SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
    cd12057
    Location:278333
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
  11. XM_006528932.2XP_006528995.1  SH3 domain-containing kinase-binding protein 1 isoform X10

    Conserved Domains (2) summary
    cd12057
    Location:3388
    SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    cl20817
    Location:322379
    GBP_C; Guanylate-binding protein, C-terminal domain
  12. XM_011247851.2XP_011246153.1  SH3 domain-containing kinase-binding protein 1 isoform X11

    See identical proteins and their annotated locations for XP_011246153.1

    UniProtKB/Swiss-Prot
    Q8R550
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