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Isy1 ISY1 splicing factor homolog [ Mus musculus (house mouse) ]

Gene ID: 57905, updated on 19-May-2024

Summary

Official Symbol
Isy1provided by MGI
Official Full Name
ISY1 splicing factor homologprovided by MGI
Primary source
MGI:MGI:1923310
See related
Ensembl:ENSMUSG00000030056 AllianceGenome:MGI:1923310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5830446M03Rik
Summary
Predicted to be involved in generation of catalytic spliceosome for second transesterification step and mRNA 3'-splice site recognition. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleus. Predicted to be part of Prp19 complex and spliceosomal complex. Orthologous to several human genes including ISY1-RAB43 (ISY1-RAB43 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 22.8), liver E14 (RPKM 16.7) and 28 other tissues See more
Orthologs
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Genomic context

See Isy1 in Genome Data Viewer
Location:
6 D1; 6 39.13 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (87795429..87815723, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (87818447..87838923, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene glycoprotein 9 platelet Neighboring gene STARR-seq mESC enhancer starr_16566 Neighboring gene RAB43, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E10388 Neighboring gene STARR-positive B cell enhancer ABC_E11324 Neighboring gene STARR-seq mESC enhancer starr_16567 Neighboring gene cellular nucleic acid binding protein Neighboring gene STARR-seq mESC enhancer starr_16568 Neighboring gene STARR-positive B cell enhancer ABC_E2793 Neighboring gene coatomer protein complex, subunit gamma 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in generation of catalytic spliceosome for second transesterification step IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA 3'-splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of U2-type catalytic step 1 spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of post-mRNA release spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of post-spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pre-mRNA-splicing factor ISY1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417641.1NP_001404570.1  pre-mRNA-splicing factor ISY1 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158626
  2. NM_133934.5NP_598695.1  pre-mRNA-splicing factor ISY1 homolog isoform 2

    See identical proteins and their annotated locations for NP_598695.1

    Status: VALIDATED

    Source sequence(s)
    AC158626
    Consensus CDS
    CCDS39548.1
    UniProtKB/Swiss-Prot
    Q69ZQ2, Q8VDX4, Q9D3E2
    Related
    ENSMUSP00000086923.5, ENSMUST00000089497.7
    Conserved Domains (1) summary
    pfam06246
    Location:1266
    Isy1; Isy1-like splicing family

RNA

  1. NR_184547.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158626
  2. NR_184548.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158626

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    87795429..87815723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)