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SLC46A2 solute carrier family 46 member 2 [ Homo sapiens (human) ]

Gene ID: 57864, updated on 21-Dec-2019

Summary

Official Symbol
SLC46A2provided by HGNC
Official Full Name
solute carrier family 46 member 2provided by HGNC
Primary source
HGNC:HGNC:16055
See related
Ensembl:ENSG00000119457 MIM:608956
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ly110; TSCOT
Expression
Biased expression in lung (RPKM 9.2), skin (RPKM 5.1) and 6 other tissues See more
Orthologs

Genomic context

See SLC46A2 in Genome Data Viewer
Location:
9q32
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (112878920..112895538, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (115641200..115653193, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987117 Neighboring gene sorting nexin family member 30 Neighboring gene uncharacterized LOC107987118 Neighboring gene uncharacterized LOC112268054 Neighboring gene major urinary protein, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
symporter activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
T cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
thymus development IEA
Inferred from Electronic Annotation
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
thymic stromal cotransporter homolog
Names
thymic stromal co-transporter

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033051.4NP_149040.3  thymic stromal cotransporter homolog

    See identical proteins and their annotated locations for NP_149040.3

    Status: VALIDATED

    Source sequence(s)
    AF242557, BC048285, DA593062
    Consensus CDS
    CCDS6786.1
    UniProtKB/Swiss-Prot
    Q9BY10
    UniProtKB/TrEMBL
    A0A024QYV1
    Related
    ENSP00000363345.4, ENST00000374228.5
    Conserved Domains (2) summary
    pfam07690
    Location:84421
    MFS_1; Major Facilitator Superfamily
    cl21472
    Location:282453
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    112878920..112895538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001746356.2 RNA Sequence

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