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CADM3 cell adhesion molecule 3 [ Homo sapiens (human) ]

Gene ID: 57863, updated on 3-Jun-2018
Official Symbol
CADM3provided by HGNC
Official Full Name
cell adhesion molecule 3provided by HGNC
Primary source
HGNC:HGNC:17601
See related
Ensembl:ENSG00000162706 MIM:609743; Vega:OTTHUMG00000037177
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BIgR; NECL1; TSLL1; IGSF4B; Necl-1; synCAM3
Summary
The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene. [provided by RefSeq, Oct 2016]
Expression
Biased expression in brain (RPKM 106.6), placenta (RPKM 39.2) and 4 other tissues See more
Orthologs
See CADM3 in Genome Data Viewer
Location:
1q23.2
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (159171564..159203313)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159141377..159172932)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene absent in melanoma 2 Neighboring gene RAD1 pseudogene 2 Neighboring gene transfer RNA-Arg (TCT) 4-1 Neighboring gene RNA, 5S ribosomal pseudogene 60 Neighboring gene CADM3 antisense RNA 1 Neighboring gene atypical chemokine receptor 1 (Duffy blood group) Neighboring gene mucosal pentraxin 1 (pseudogene)

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.
NHGRI GWA Catalog
Genome-wide association with select biomarker traits in the Framingham Heart Study.
NHGRI GWA Catalog
  • Adherens junctions interactions, organism-specific biosystem (from REACTOME)
    Adherens junctions interactions, organism-specific biosystemThe adherens junctions (AJ) are multiprotein complexes that promote homotypic cell adhesion in nearly all types of tissue by linking membrane and cytoskeletal components at discrete contact regions (...
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell junction organization, organism-specific biosystem (from REACTOME)
    Cell junction organization, organism-specific biosystem
    Cell junction organization
  • Cell-Cell communication, organism-specific biosystem (from REACTOME)
    Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
  • Cell-cell junction organization, organism-specific biosystem (from REACTOME)
    Cell-cell junction organization, organism-specific biosystemEpithelial cell-cell contacts consist of three major adhesion systems: adherens junctions (AJs), tight junctions (TJs), and desmosomes. These adhesion systems differ in their function and compositio...
  • Nectin/Necl trans heterodimerization, organism-specific biosystem (from REACTOME)
    Nectin/Necl trans heterodimerization, organism-specific biosystemNectins and Nectin-like molecules (Necls) also undergo trans-heterophilic interactions to interact with other nectin or Necl family members. Besides these trans interactions among nectins and nectin-...

Markers

Homology

Clone Names

  • FLJ10698

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
adherens junction organization TAS
Traceable Author Statement
more info
 
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein localization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
cell adhesion molecule 3
Names
TSLC1-like 1
brain immunoglobulin receptor
dendritic cell nectin-like protein 1 short isoform
immunoglobulin superfamily member 4B
synaptic cell adhesion molecule 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051933.1 RefSeqGene

    Range
    5001..36750
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001127173.2NP_001120645.1  cell adhesion molecule 3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001120645.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF363367, DA221489, HY346099
    Consensus CDS
    CCDS44251.1
    UniProtKB/Swiss-Prot
    Q8N126
    Related
    ENSP00000357107.4, OTTHUMP00000035289, ENST00000368125.8, OTTHUMT00000090330
    Conserved Domains (5) summary
    smart00294
    Location:354369
    4.1m; putative band 4.1 homologues' binding motif
    cd05882
    Location:32126
    Ig1_Necl-1; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3))
    cd07705
    Location:147229
    Ig2_Necl-1; Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3))
    smart00410
    Location:245316
    IG_like; Immunoglobulin like
    pfam13895
    Location:237302
    Ig_2; Immunoglobulin domain
  2. NM_001346510.1NP_001333439.1  cell adhesion molecule 3 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL035403
    UniProtKB/Swiss-Prot
    Q8N126
  3. NM_021189.4NP_067012.1  cell adhesion molecule 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_067012.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF363367, AK289541, AL035403, DA221489, HY346099
    Consensus CDS
    CCDS1182.1
    UniProtKB/Swiss-Prot
    Q8N126
    Related
    ENSP00000357106.4, OTTHUMP00000035290, ENST00000368124.8, OTTHUMT00000090331
    Conserved Domains (4) summary
    cd05882
    Location:66160
    Ig1_Necl-1; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3))
    cd07705
    Location:181263
    Ig2_Necl-1; Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3))
    smart00410
    Location:279350
    IG_like; Immunoglobulin like
    pfam13895
    Location:271336
    Ig_2; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    159171564..159203313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448760.1XP_024304528.1  cell adhesion molecule 3 isoform X1

    Conserved Domains (4) summary
    smart00294
    Location:437452
    4.1m; putative band 4.1 homologues' binding motif
    cd05882
    Location:115209
    Ig1_Necl-1; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3))
    cd07705
    Location:230312
    Ig2_Necl-1; Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3))
    smart00410
    Location:328399
    IG_like; Immunoglobulin like
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