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Wdr4 WD repeat domain 4 [ Mus musculus (house mouse) ]

Gene ID: 57773, updated on 13-Oct-2022

Summary

Official Symbol
Wdr4provided by MGI
Official Full Name
WD repeat domain 4provided by MGI
Primary source
MGI:MGI:1889002
See related
Ensembl:ENSMUSG00000024037 AllianceGenome:MGI:1889002
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wh; mWH; D530049K22Rik
Summary
Predicted to contribute to tRNA (guanine-N7-)-methyltransferase activity. Predicted to be involved in tRNA modification. Predicted to act upstream of or within cellular response to DNA damage stimulus and tRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of tRNA methyltransferase complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and thymus. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome. Orthologous to human WDR4 (WD repeat domain 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 9.8), limb E14.5 (RPKM 7.4) and 28 other tissues See more
Orthologs
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Genomic context

See Wdr4 in Genome Data Viewer
Location:
17; 17 B1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (31713296..31738946, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (31494322..31519985, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 37 (glycerol-3-phosphate transporter), member 1 Neighboring gene predicted gene, 30139 Neighboring gene phosphodiesterase 9A Neighboring gene predicted gene 9902 Neighboring gene NADH:ubiquinone oxidoreductase core subunit V3 Neighboring gene predicted gene, 50105

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in RNA (guanine-N7)-methylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tRNA modification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of tRNA methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of tRNA methyltransferase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
Names
WD repeat-containing protein 4
WD40 repeat protein 4
protein Wuho homolog
tRNA (guanine-N(7)-)-methyltransferase subunit WDR4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405110.1NP_001392039.1  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AC166172
  2. NM_001405114.1NP_001392043.1  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC166172
  3. NM_001405117.1NP_001392046.1  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC166172
  4. NM_001405119.1NP_001392048.1  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC166172
  5. NM_001405120.1NP_001392049.1  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC166172
  6. NM_021322.3NP_067297.2  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform a

    See identical proteins and their annotated locations for NP_067297.2

    Status: VALIDATED

    Source sequence(s)
    AC166172
    Consensus CDS
    CCDS28606.2
    UniProtKB/Swiss-Prot
    Q9EP82
    UniProtKB/TrEMBL
    E9Q156
    Related
    ENSMUSP00000126061.2, ENSMUST00000171171.9
    Conserved Domains (3) summary
    COG2319
    Location:187362
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:110147
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:60272
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    31713296..31738946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249935.2XP_030105795.1  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:642
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:33128
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_036160713.1XP_036016606.1  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:642
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:33128
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_006524715.5XP_006524778.1  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X1

    See identical proteins and their annotated locations for XP_006524778.1

    UniProtKB/TrEMBL
    E9Q156
    Conserved Domains (3) summary
    COG2319
    Location:187362
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:110147
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:60272
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_006524725.5XP_006524788.1  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:642
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:33128
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_036160712.1XP_036016605.1  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:642
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:33128
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_006524719.5XP_006524782.1  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X2

    See identical proteins and their annotated locations for XP_006524782.1

    Conserved Domains (2) summary
    sd00039
    Location:642
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:33128
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. XM_006524724.3XP_006524787.1  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X2

    See identical proteins and their annotated locations for XP_006524787.1

    Conserved Domains (2) summary
    sd00039
    Location:642
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:33128
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. XM_011246553.4XP_011244855.1  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X2

    See identical proteins and their annotated locations for XP_011244855.1

    Conserved Domains (2) summary
    sd00039
    Location:642
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:33128
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  9. XM_006524720.5XP_006524783.1  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:642
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:33128
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  10. XM_030249933.2XP_030105793.1  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:187362
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:110147
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:60272
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  11. XM_030249934.2XP_030105794.1  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:642
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:33128
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  12. XM_006524716.5XP_006524779.1  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X1

    See identical proteins and their annotated locations for XP_006524779.1

    UniProtKB/TrEMBL
    E9Q156
    Conserved Domains (3) summary
    COG2319
    Location:187362
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:110147
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:60272
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  13. XM_006524723.4XP_006524786.1  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X2

    See identical proteins and their annotated locations for XP_006524786.1

    Conserved Domains (2) summary
    sd00039
    Location:642
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:33128
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...