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NCOA5 nuclear receptor coactivator 5 [ Homo sapiens (human) ]

Gene ID: 57727, updated on 5-Jul-2020

Summary

Official Symbol
NCOA5provided by HGNC
Official Full Name
nuclear receptor coactivator 5provided by HGNC
Primary source
HGNC:HGNC:15909
See related
Ensembl:ENSG00000124160 MIM:616825
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIA; bA465L10.6
Summary
This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017]
Expression
Ubiquitous expression in testis (RPKM 19.7), ovary (RPKM 15.7) and 25 other tissues See more
Orthologs

Genomic context

See NCOA5 in Genome Data Viewer
Location:
20q13.12
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (46060991..46089962, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44689624..44718580, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 12 member 5 Neighboring gene Sharpr-MPRA regulatory region 13245 Neighboring gene Sharpr-MPRA regulatory region 3425 Neighboring gene ribosomal protein L13 pseudogene 2 Neighboring gene CD40 molecule

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
extracellular space HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
nuclear receptor coactivator 5
Names
NCoA-5
coactivator independent of AF-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348148.2NP_001335077.1  nuclear receptor coactivator 5 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL035662, AL162458
    Conserved Domains (1) summary
    cl28413
    Location:81151
    HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
  2. NM_001348149.2NP_001335078.1  nuclear receptor coactivator 5 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL035662, AL162458
    Conserved Domains (2) summary
    cl28310
    Location:32118
    Rho; Transcription termination factor Rho [Transcription]
    cl28413
    Location:186256
    HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
  3. NM_001348150.2NP_001335079.1  nuclear receptor coactivator 5 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL035662, AL162458, BC056872, CN369226
    Conserved Domains (1) summary
    cl28413
    Location:123193
    HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
  4. NM_001348151.2NP_001335080.1  nuclear receptor coactivator 5 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL035662, AL162458
    Conserved Domains (1) summary
    cl28413
    Location:81151
    HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
  5. NM_020967.3NP_066018.1  nuclear receptor coactivator 5 isoform 1

    See identical proteins and their annotated locations for NP_066018.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF230533, AL035662, AL162458, CN369226
    Consensus CDS
    CCDS13392.1
    UniProtKB/Swiss-Prot
    Q9HCD5
    Related
    ENSP00000290231.6, ENST00000290231.11
    Conserved Domains (1) summary
    pfam03153
    Location:400576
    TFIIA; Transcription factor IIA, alpha/beta subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    46060991..46089962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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