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WDFY4 WDFY family member 4 [ Homo sapiens (human) ]

Gene ID: 57705, updated on 26-Oct-2022

Summary

Official Symbol
WDFY4provided by HGNC
Official Full Name
WDFY family member 4provided by HGNC
Primary source
HGNC:HGNC:29323
See related
Ensembl:ENSG00000128815 MIM:613316; AllianceGenome:HGNC:29323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C10orf64
Summary
Predicted to be involved in autophagy. Predicted to act upstream of or within with a positive effect on CD8-positive, alpha-beta T cell activation. Predicted to act upstream of or within antigen processing and presentation and cellular response to virus. Predicted to be located in early endosome and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lymph node (RPKM 13.1), spleen (RPKM 9.3) and 10 other tissues See more
Orthologs
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Genomic context

See WDFY4 in Genome Data Viewer
Location:
10q11.23
Exon count:
67
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (48684873..48982956)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (49534432..49832184)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (49892918..50191001)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 22 Neighboring gene Sharpr-MPRA regulatory region 14185 Neighboring gene ARHGAP22 intronic transcript 1 Neighboring gene ribosomal protein L13a pseudogene 19 Neighboring gene uncharacterized LOC105378299 Neighboring gene leucine rich repeat containing 18 Neighboring gene uncharacterized LOC105378298 Neighboring gene microRNA 4294 Neighboring gene V-set and transmembrane domain containing 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.
EBI GWAS Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog
Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study.
EBI GWAS Catalog
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
EBI GWAS Catalog
Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus.
EBI GWAS Catalog
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
EBI GWAS Catalog
Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ17416, FLJ36288, FLJ45748, KIAA1607, MGC40604, MGC45899

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in CD8-positive, alpha-beta T cell activation IEA
Inferred from Electronic Annotation
more info
 
involved_in antigen processing and presentation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to virus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
WD repeat- and FYVE domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370153.1NP_001357082.1  WD repeat- and FYVE domain-containing protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC035139, AC068898
  2. NM_001370154.1NP_001357083.1  WD repeat- and FYVE domain-containing protein 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC068898, BC034937
    Consensus CDS
    CCDS91241.1
    Related
    ENSP00000354141.2, ENST00000360890.6
  3. NM_001394531.1NP_001381460.1  WD repeat- and FYVE domain-containing protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC035139, AC060234, AC068898
    Consensus CDS
    CCDS44385.1
    UniProtKB/Swiss-Prot
    Q9HCG5
    Related
    ENSP00000320563.5, ENST00000325239.12
    Conserved Domains (4) summary
    cd01201
    Location:23882512
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
    sd00039
    Location:29372980
    7WD40; WD40 repeat [structural motif]
    pfam02138
    Location:25402821
    Beach; Beige/BEACH domain
    cl29593
    Location:29023100
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_020945.2NP_065996.1  WD repeat- and FYVE domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_065996.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC035139, AC060234, AC068898
    Consensus CDS
    CCDS44385.1
    UniProtKB/Swiss-Prot
    Q6ZS81, Q9HCG5
    Conserved Domains (4) summary
    cd01201
    Location:23882512
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
    sd00039
    Location:29372980
    7WD40; WD40 repeat [structural motif]
    pfam02138
    Location:25402821
    Beach; Beige/BEACH domain
    cl29593
    Location:29023100
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    48684873..48982956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539988.3XP_011538290.1  WD repeat- and FYVE domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011538290.1

    UniProtKB/Swiss-Prot
    Q6ZS81, Q9HCG5
    Conserved Domains (4) summary
    cd01201
    Location:23882512
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
    sd00039
    Location:29372980
    7WD40; WD40 repeat [structural motif]
    pfam02138
    Location:25402821
    Beach; Beige/BEACH domain
    cl29593
    Location:29023100
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_017016463.2XP_016871952.1  WD repeat- and FYVE domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZS81, Q9HCG5
    Conserved Domains (4) summary
    cd01201
    Location:23882512
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
    sd00039
    Location:29372980
    7WD40; WD40 repeat [structural motif]
    pfam02138
    Location:25402821
    Beach; Beige/BEACH domain
    cl29593
    Location:29023100
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_011539986.4XP_011538288.3  WD repeat- and FYVE domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9HCG5
  4. XM_011539987.3XP_011538289.3  WD repeat- and FYVE domain-containing protein 4 isoform X2

  5. XM_011539990.4XP_011538292.2  WD repeat- and FYVE domain-containing protein 4 isoform X4

  6. XM_011539991.4XP_011538293.2  WD repeat- and FYVE domain-containing protein 4 isoform X5

    UniProtKB/TrEMBL
    A0A1W7HCV9
  7. XM_011539992.3XP_011538294.2  WD repeat- and FYVE domain-containing protein 4 isoform X7

  8. XM_047425565.1XP_047281521.1  WD repeat- and FYVE domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9HCG5
  9. XM_047425566.1XP_047281522.1  WD repeat- and FYVE domain-containing protein 4 isoform X3

  10. XM_017016464.1XP_016871953.1  WD repeat- and FYVE domain-containing protein 4 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    49534432..49832184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)