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DPP10 dipeptidyl peptidase like 10 [ Homo sapiens (human) ]

Gene ID: 57628, updated on 17-Jun-2019

Summary

Official Symbol
DPP10provided by HGNC
Official Full Name
dipeptidyl peptidase like 10provided by HGNC
Primary source
HGNC:HGNC:20823
See related
Ensembl:ENSG00000175497 MIM:608209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPL2; DPPY; DPRP3; DPRP-3
Summary
This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 7.5), adrenal (RPKM 2.9) and 2 other tissues See more
Orthologs

Genomic context

See DPP10 in Genome Data Viewer
Location:
2q14.1
Exon count:
33
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (114442641..115845752)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (115199899..116603328)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene selenophosphate synthetase 1 pseudogene 7 Neighboring gene RNA, U2 small nuclear 41, pseudogene Neighboring gene DPP10 antisense RNA 3 Neighboring gene uncharacterized LOC105373575 Neighboring gene uncharacterized LOC105373574 Neighboring gene uncharacterized LOC107985937 Neighboring gene DPP10 antisense RNA 1 Neighboring gene uncharacterized LOC107985938 Neighboring gene ribosomal protein SA pseudogene 23 Neighboring gene uncharacterized LOC105373572 Neighboring gene uncharacterized LOC105373576 Neighboring gene MT-CYB pseudogene 39

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT dipeptidyl-peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
potassium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
voltage-gated potassium channel complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
inactive dipeptidyl peptidase 10
Names
DPP X
dipeptidyl peptidase 10
dipeptidyl peptidase IV-related protein 3
dipeptidyl peptidase X
dipeptidyl peptidase-like protein 2
dipeptidyl-peptidase 10 (inactive)
dipeptidyl-peptidase 10 (non-functional)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004360.4NP_001004360.3  inactive dipeptidyl peptidase 10 isoform short

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 3. The resulting isoform (short, also referred to as DPL2-s and d) has a shorter and distinct N-terminus when compared to isoform c.
    Source sequence(s)
    AC016721, AC017040, AC066593, AC067947, AC105422
    Consensus CDS
    CCDS33278.1
    Related
    ENSP00000309066.8, ENST00000310323.12
  2. NM_001178034.1NP_001171505.1  inactive dipeptidyl peptidase 10 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC016721, AC066593, DQ857322
    Consensus CDS
    CCDS54388.1
    UniProtKB/Swiss-Prot
    Q8N608
    Related
    ENSP00000376855.2, ENST00000393147.6
    Conserved Domains (2) summary
    pfam00326
    Location:584786
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:137503
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
  3. NM_001178036.2NP_001171507.2  inactive dipeptidyl peptidase 10 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate 5' exon, as compared to variant 3. The resulting isoform (a) has a shorter and distinct N-terminus when compared to isoform c.
    Source sequence(s)
    AC010885, AC016721, AC017040, AC067947, AC105422
    Consensus CDS
    CCDS54389.1
    Related
    ENSP00000387038.1, ENST00000409163.5
  4. NM_001178037.2NP_001171508.2  inactive dipeptidyl peptidase 10 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate 5' exon, as compared to variant 3. The resulting isoform (b) has a shorter and distinct N-terminus when compared to isoform c.
    Source sequence(s)
    AC016721, AC017040, AC067947, AC093610, AC105422
  5. NM_001321905.2NP_001308834.2  inactive dipeptidyl peptidase 10 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC010885, AC012071, AC016721, AC017040, AC067947, AC105422
  6. NM_001321906.1NP_001308835.1  inactive dipeptidyl peptidase 10 isoform short

    Status: VALIDATED

    Source sequence(s)
    AC016721, AC066593, BM974067, DQ857322
    Consensus CDS
    CCDS33278.1
    UniProtKB/Swiss-Prot
    Q8N608
    UniProtKB/TrEMBL
    Q0GLB7
    Conserved Domains (2) summary
    pfam00326
    Location:573775
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:126492
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
  7. NM_001321907.2NP_001308836.2  inactive dipeptidyl peptidase 10 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC010885, AC016721, AC017040, AC067947, AC105422
  8. NM_001321908.2NP_001308837.2  inactive dipeptidyl peptidase 10 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC010885, AC016721, AC017040, AC067947, AC105422
  9. NM_001321909.2NP_001308838.2  inactive dipeptidyl peptidase 10 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC016721, AC017040, AC066593, AC067947, AC105422
  10. NM_001321910.2NP_001308839.2  inactive dipeptidyl peptidase 10 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC010885, AC012071, AC016721, AC017040, AC067947, AC105422
    Consensus CDS
    CCDS54389.1
  11. NM_001321911.2NP_001308840.2  inactive dipeptidyl peptidase 10 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC010885, AC016721, AC017040, AC067947, AC105422
    Consensus CDS
    CCDS54389.1
  12. NM_001321912.2NP_001308841.2  inactive dipeptidyl peptidase 10 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC010885, AC016721, AC017040, AC067947, AC105422
  13. NM_001321913.2NP_001308842.2  inactive dipeptidyl peptidase 10 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC010885, AC016721, AC017040, AC067947, AC105422
  14. NM_001321914.1NP_001308843.1  inactive dipeptidyl peptidase 10 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC016721, AC066593, BM974067, DQ857322
    UniProtKB/Swiss-Prot
    Q8N608
    Conserved Domains (2) summary
    pfam00326
    Location:326528
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:1245
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
  15. NM_020868.5NP_065919.3  inactive dipeptidyl peptidase 10 isoform long

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has an alternate 5' exon, as compared to variant 3. The resulting isoform (long, also referred to as DPL2-l) is slightly shorter and has a distinct N-terminus when compared to isoform c.
    Source sequence(s)
    AC010885, AC016721, AC017040, AC067947, AC105422
    Consensus CDS
    CCDS46400.1
    Related
    ENSP00000386565.1, ENST00000410059.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    114442641..115845752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453023.1XP_024308791.1  inactive dipeptidyl peptidase 10 isoform X1

    Conserved Domains (2) summary
    pfam00326
    Location:560762
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:126479
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
  2. XM_017004566.1XP_016860055.1  inactive dipeptidyl peptidase 10 isoform X2

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