Format

Send to:

Choose Destination

RIC1 RIC1 homolog, RAB6A GEF complex partner 1 [ Homo sapiens (human) ]

Gene ID: 57589, updated on 2-Mar-2021

Summary

Official Symbol
RIC1provided by HGNC
Official Full Name
RIC1 homolog, RAB6A GEF complex partner 1provided by HGNC
Primary source
HGNC:HGNC:17686
See related
Ensembl:ENSG00000107036 MIM:610354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CATIFA; CIP150; KIAA1432; bA207C16.1
Expression
Ubiquitous expression in lymph node (RPKM 6.0), testis (RPKM 5.0) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See RIC1 in Genome Data Viewer
Location:
9p24.1
Exon count:
28
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (5629030..5778633)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (5629107..5776557)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene CD274 molecule Neighboring gene programmed cell death 1 ligand 2 Neighboring gene endoplasmic reticulum metallopeptidase 1 Neighboring gene Sharpr-MPRA regulatory region 2314 Neighboring gene adenylate kinase 4 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12580, KIAA1432

Gene Ontology Provided by GOA

Function Evidence Code Pubs
guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
small GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cranial skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cellular protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of extracellular matrix constituent secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Ric1-Rgp1 guanyl-nucleotide exchange factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Ric1-Rgp1 guanyl-nucleotide exchange factor complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
guanine nucleotide exchange factor subunit RIC1
Names
RAB6A GEF complex partner 1
RAB6A-GEF complex partner protein 1
connexin 43-interacting protein 150 kDa
connexin-43-interacting protein of 150 kDa
protein RIC1 homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135920.4NP_001129392.2  guanine nucleotide exchange factor subunit RIC1 isoform b

    See identical proteins and their annotated locations for NP_001129392.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AL136875, AL136980, AL354744
    Consensus CDS
    CCDS47949.2
    UniProtKB/Swiss-Prot
    Q4ADV7
    Related
    ENSP00000251879.6, ENST00000251879.10
    Conserved Domains (1) summary
    pfam07064
    Location:733990
    RIC1; RIC1
  2. NM_001206557.2NP_001193486.1  guanine nucleotide exchange factor subunit RIC1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks and in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a.
    Source sequence(s)
    AA250979, AL136875, AL136980, AL354744, BC144296
    Consensus CDS
    CCDS75811.1
    UniProtKB/Swiss-Prot
    Q4ADV7
    Related
    ENSP00000402240.4, ENST00000418622.7
    Conserved Domains (1) summary
    pfam07064
    Location:696953
    RIC1; RIC1
  3. NM_020829.4NP_065880.2  guanine nucleotide exchange factor subunit RIC1 isoform a

    See identical proteins and their annotated locations for NP_065880.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA250979, AL136875, AL136980, AL354744, BC136616
    Consensus CDS
    CCDS34982.2
    UniProtKB/Swiss-Prot
    Q4ADV7
    Related
    ENSP00000416696.2, ENST00000414202.7
    Conserved Domains (1) summary
    pfam07064
    Location:733990
    RIC1; RIC1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    5629030..5778633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251523.3XP_005251580.1  guanine nucleotide exchange factor subunit RIC1 isoform X1

    See identical proteins and their annotated locations for XP_005251580.1

    Conserved Domains (1) summary
    pfam07064
    Location:732989
    RIC1; RIC1
  2. XM_017014934.1XP_016870423.1  guanine nucleotide exchange factor subunit RIC1 isoform X2

  3. XM_017014936.1XP_016870425.1  guanine nucleotide exchange factor subunit RIC1 isoform X2

  4. XM_017014935.1XP_016870424.1  guanine nucleotide exchange factor subunit RIC1 isoform X2

  5. XM_011517967.2XP_011516269.1  guanine nucleotide exchange factor subunit RIC1 isoform X3

    Conserved Domains (1) summary
    pfam07064
    Location:422679
    RIC1; RIC1
  6. XM_011517968.2XP_011516270.1  guanine nucleotide exchange factor subunit RIC1 isoform X4

    Conserved Domains (1) summary
    pfam07064
    Location:196453
    RIC1; RIC1

RNA

  1. XR_428426.3 RNA Sequence

Support Center