Format

Send to:

Choose Destination

MARCHF4 membrane associated ring-CH-type finger 4 [ Homo sapiens (human) ]

Gene ID: 57574, updated on 21-Dec-2019

Summary

Official Symbol
MARCHF4provided by HGNC
Official Full Name
membrane associated ring-CH-type finger 4provided by HGNC
Primary source
HGNC:HGNC:29269
See related
Ensembl:ENSG00000144583 MIM:608208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MARCH4; RNF174; MARCH-IV
Summary
MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]
Expression
Biased expression in brain (RPKM 3.9), stomach (RPKM 1.1) and 2 other tissues See more
Orthologs

Genomic context

See MARCHF4 in Genome Data Viewer
Location:
2q35
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (216257865..216372483, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (217122585..217236750, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene X-ray repair cross complementing 5 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene long intergenic non-protein coding RNA 1963 Neighboring gene uncharacterized LOC107985983 Neighboring gene uncharacterized LOC107985985 Neighboring gene uncharacterized LOC107985984 Neighboring gene Sharpr-MPRA regulatory region 13820 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis identifies susceptibility loci for migraine without aura.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC104908

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi stack IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase MARCH4
Names
RING finger protein 174
RING-type E3 ubiquitin transferase MARCH4
membrane associated ring finger 4
membrane-associated RING finger protein 4
membrane-associated RING-CH protein IV
membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
NP_065865.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020814.3NP_065865.1  E3 ubiquitin-protein ligase MARCH4 precursor

    See identical proteins and their annotated locations for NP_065865.1

    Status: VALIDATED

    Source sequence(s)
    AB037820, AC012513, AC098820, AW051292, BC048793, BC098448
    Consensus CDS
    CCDS33376.1
    UniProtKB/Swiss-Prot
    Q9P2E8
    Related
    ENSP00000273067.3, ENST00000273067.5
    Conserved Domains (1) summary
    smart00744
    Location:163208
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    216257865..216372483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center