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MARCHF4 membrane associated ring-CH-type finger 4 [ Homo sapiens (human) ]

Gene ID: 57574, updated on 11-Jun-2025
Official Symbol
MARCHF4provided by HGNC
Official Full Name
membrane associated ring-CH-type finger 4provided by HGNC
Primary source
HGNC:HGNC:29269
See related
Ensembl:ENSG00000144583 MIM:608208; AllianceGenome:HGNC:29269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MARCH4; RNF174; MARCH-IV
Summary
MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]
Expression
Biased expression in brain (RPKM 3.9), stomach (RPKM 1.1) and 2 other tissues See more
Orthologs
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See MARCHF4 in Genome Data Viewer
Location:
2q35
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (216257865..216372483, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (216740406..216854601, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (217122588..217237206, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene X-ray repair cross complementing 5 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17093 Neighboring gene long intergenic non-protein coding RNA 1963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:217147950-217148470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:217148471-217148990 Neighboring gene MARCHF4 antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:217180211-217181410 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:217183431-217184162 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:217184163-217184894 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:217205324-217206036 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:217214111-217214808 Neighboring gene SMARCAL1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:217256655-217257184 Neighboring gene uncharacterized LOC107985984 Neighboring gene Sharpr-MPRA regulatory region 13820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17096 Neighboring gene SNF2 related chromatin remodeling annealing helicase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:217339556-217340056

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

EBI GWAS Catalog

Description
Genome-wide association analysis identifies susceptibility loci for migraine without aura.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC104908

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in Golgi stack IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi stack IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi stack IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
E3 ubiquitin-protein ligase MARCHF4
Names
E3 ubiquitin-protein ligase MARCH4
RING finger protein 174
RING-type E3 ubiquitin transferase MARCH4
RING-type E3 ubiquitin transferase MARCHF4
membrane associated ring finger 4
membrane-associated RING finger protein 4
membrane-associated RING-CH protein IV
membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
NP_065865.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020814.3NP_065865.1  E3 ubiquitin-protein ligase MARCHF4 precursor

    See identical proteins and their annotated locations for NP_065865.1

    Status: VALIDATED

    Source sequence(s)
    AB037820, AC012513, AC098820, AW051292, BC048793, BC098448
    Consensus CDS
    CCDS33376.1
    UniProtKB/Swiss-Prot
    Q4KMN7, Q86WR8, Q9P2E8
    Related
    ENSP00000273067.3, ENST00000273067.5
    Conserved Domains (1) summary
    smart00744
    Location:163208
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    216257865..216372483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    216740406..216854601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)