Format

Send to:

Choose Destination

SIPA1L2 signal induced proliferation associated 1 like 2 [ Homo sapiens (human) ]

Gene ID: 57568, updated on 5-May-2020

Summary

Official Symbol
SIPA1L2provided by HGNC
Official Full Name
signal induced proliferation associated 1 like 2provided by HGNC
Primary source
HGNC:HGNC:23800
See related
Ensembl:ENSG00000116991 MIM:611609
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPAL2; SPAR2
Summary
This gene encodes a member of the signal-induced proliferation-associated 1 like family. Members of this family contain a GTPase activating domain, a PDZ domain and a C-terminal coiled-coil domain with a leucine zipper. A similar protein in rat acts as a GTPases for the small GTPase Rap. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in heart (RPKM 11.7), placenta (RPKM 10.4) and 24 other tissues See more
Orthologs

Genomic context

See SIPA1L2 in Genome Data Viewer
Location:
1q42.2
Exon count:
25
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (232397965..232630496, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (232533711..232765907, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373196 Neighboring gene uncharacterized LOC105373198 Neighboring gene RNA, U6 small nuclear 1211, pseudogene Neighboring gene long intergenic non-protein coding RNA 1745

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of clinical symptoms of dissociation in a trauma-exposed sample.
NHGRI GWA Catalog
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
NHGRI GWA Catalog
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
NHGRI GWA Catalog
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
NHGRI GWA Catalog
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23126, FLJ23632, KIAA1389

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
signal-induced proliferation-associated 1-like protein 2
Names
SIPA1-like protein 2
SPA-1-like 2
spine-associated RapGAP 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377488.1NP_001364417.1  signal-induced proliferation-associated 1-like protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL157409, AL355274, AL356965
  2. NM_020808.5NP_065859.3  signal-induced proliferation-associated 1-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_065859.3

    Status: REVIEWED

    Source sequence(s)
    AL157409, AL355274, AL356965
    Consensus CDS
    CCDS41474.1
    UniProtKB/Swiss-Prot
    Q9P2F8
    Conserved Domains (3) summary
    cd00992
    Location:9501020
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:625805
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14231666
    SPAR_C; C-terminal domain of SPAR protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    232397965..232630496 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001896.1XP_016857385.1  signal-induced proliferation-associated 1-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9P2F8
    Conserved Domains (3) summary
    cd00992
    Location:9501020
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:625805
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14231666
    SPAR_C; C-terminal domain of SPAR protein
  2. XM_005273212.4XP_005273269.1  signal-induced proliferation-associated 1-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005273269.1

    UniProtKB/Swiss-Prot
    Q9P2F8
    Conserved Domains (3) summary
    cd00992
    Location:9501020
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:625805
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14231666
    SPAR_C; C-terminal domain of SPAR protein
  3. XM_011544243.2XP_011542545.1  signal-induced proliferation-associated 1-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011542545.1

    UniProtKB/Swiss-Prot
    Q9P2F8
    Conserved Domains (3) summary
    cd00992
    Location:9501020
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:625805
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14231666
    SPAR_C; C-terminal domain of SPAR protein
  4. XM_005273213.4XP_005273270.1  signal-induced proliferation-associated 1-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005273270.1

    UniProtKB/Swiss-Prot
    Q9P2F8
    Related
    ENSP00000262861.4, ENST00000262861.8
    Conserved Domains (3) summary
    cd00992
    Location:9501020
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:625805
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14231666
    SPAR_C; C-terminal domain of SPAR protein
  5. XM_017001897.2XP_016857386.1  signal-induced proliferation-associated 1-like protein 2 isoform X2

    Conserved Domains (3) summary
    cd00992
    Location:9501020
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:625805
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14231648
    SPAR_C; C-terminal domain of SPAR protein
Support Center