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KLHL42 kelch like family member 42 [ Homo sapiens (human) ]

Gene ID: 57542, updated on 21-Dec-2019

Summary

Official Symbol
KLHL42provided by HGNC
Official Full Name
kelch like family member 42provided by HGNC
Primary source
HGNC:HGNC:29252
See related
Ensembl:ENSG00000087448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ctb9; KLHDC5
Expression
Ubiquitous expression in brain (RPKM 7.6), endometrium (RPKM 5.0) and 25 other tissues See more
Orthologs

Genomic context

See KLHL42 in Genome Data Viewer
Location:
12p11.22
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (27780233..27803040)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (27933187..27955973)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S35 Neighboring gene MANSC domain containing 4 Neighboring gene uncharacterized LOC105369709 Neighboring gene RN7SK pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1340, MGC131714

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of microtubule-based process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kelch-like protein 42
Names
cullin-3-binding protein 9
kelch domain containing 5
kelch domain-containing protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020782.2NP_065833.1  kelch-like protein 42

    See identical proteins and their annotated locations for NP_065833.1

    Status: VALIDATED

    Source sequence(s)
    AC009511
    Consensus CDS
    CCDS31763.1
    UniProtKB/Swiss-Prot
    Q9P2K6
    UniProtKB/TrEMBL
    B2RNT7
    Related
    ENSP00000370671.2, ENST00000381271.7
    Conserved Domains (4) summary
    cd14735
    Location:129169
    BACK_Kelch; BTB-And-C-terminal-Kelch (BACK) domain of Kelch-like proteins
    sd00038
    Location:244287
    Kelch; KELCH repeat [structural motif]
    cl02518
    Location:769
    BTB; BTB/POZ domain
    cl28614
    Location:210497
    BTB; Broad-Complex, Tramtrack and Bric a brac

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    27780233..27803040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019698.2XP_016875187.1  kelch-like protein 42 isoform X1

    UniProtKB/TrEMBL
    F5H523
    Related
    ENSP00000444748.1, ENST00000539176.1
    Conserved Domains (4) summary
    cd14735
    Location:129169
    BACK_Kelch; BTB-And-C-terminal-Kelch (BACK) domain of Kelch-like proteins
    sd00038
    Location:244287
    Kelch; KELCH repeat [structural motif]
    cl02518
    Location:769
    BTB; BTB/POZ domain
    cl28614
    Location:217353
    BTB; Broad-Complex, Tramtrack and Bric a brac

RNA

  1. XR_931314.3 RNA Sequence

  2. XR_931315.3 RNA Sequence

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