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MIB1 mindbomb E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

Gene ID: 57534, updated on 4-Oct-2020

Summary

Official Symbol
MIB1provided by HGNC
Official Full Name
mindbomb E3 ubiquitin protein ligase 1provided by HGNC
Primary source
HGNC:HGNC:21086
See related
Ensembl:ENSG00000101752 MIM:608677
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIB; DIP1; ZZZ6; DIP-1; LVNC7; ZZANK2
Summary
This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013]
Expression
Ubiquitous expression in thyroid (RPKM 7.2), endometrium (RPKM 6.4) and 25 other tissues See more
Orthologs

Genomic context

See MIB1 in Genome Data Viewer
Location:
18q11.2
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (21740792..21870953)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (19321290..19450918)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 3, phospholipase Neighboring gene microRNA 320c-1 Neighboring gene uncharacterized LOC105376866 Neighboring gene VISTA enhancer hs1650 Neighboring gene RNA, 7SL, cytoplasmic 233, pseudogene Neighboring gene MIR133A1 host gene Neighboring gene microRNA 133a-1 Neighboring gene microRNA 1-2 Neighboring gene ribosomal protein L34 pseudogene 32 Neighboring gene RNA, U6 small nuclear 1038, pseudogene Neighboring gene uncharacterized LOC105372016

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90676, MGC129659, MGC129660, DKFZp686I0769, DKFZp761M1710

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
blood vessel development IEA
Inferred from Electronic Annotation
more info
 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heart looping IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
neural tube formation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endocytosis IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
somitogenesis IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase MIB1
Names
DAPK-interacting protein 1
RING-type E3 ubiquitin transferase MIB1
ubiquitin ligase mind bomb
zinc finger ZZ type with ankyrin repeat domain protein 2
NP_065825.1
XP_011524400.1
XP_016881362.1
XP_016881363.1
XP_016881364.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033272.2 RefSeqGene

    Range
    41373..171001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_759

mRNA and Protein(s)

  1. NM_020774.4NP_065825.1  E3 ubiquitin-protein ligase MIB1

    See identical proteins and their annotated locations for NP_065825.1

    Status: REVIEWED

    Source sequence(s)
    AC091038, AC103987, AY149908
    Consensus CDS
    CCDS11871.1
    UniProtKB/Swiss-Prot
    Q86YT6
    Related
    ENSP00000261537.6, ENST00000261537.6
    Conserved Domains (9) summary
    PHA03095
    Location:439710
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:83127
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:562593
    ANK; ANK repeat [structural motif]
    cd16724
    Location:818854
    RING1-HC_MIB1; RING finger 1, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
    cd16725
    Location:865901
    RING2-HC_MIB1; RING finger 2, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
    cd16727
    Location:9621003
    RING3-HC_MIB1; RING finger 3, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
    pfam06701
    Location:154218
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:670770
    Ank_2; Ankyrin repeats (3 copies)
    pfam18346
    Location:333397
    SH3_15; Mind bomb SH3 repeat domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    21740792..21870953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025874.1XP_016881363.1  E3 ubiquitin-protein ligase MIB1 isoform X3

  2. XM_017025875.1XP_016881364.1  E3 ubiquitin-protein ligase MIB1 isoform X4

  3. XM_017025873.1XP_016881362.1  E3 ubiquitin-protein ligase MIB1 isoform X1

  4. XM_011526098.1XP_011524400.1  E3 ubiquitin-protein ligase MIB1 isoform X2

    Conserved Domains (4) summary
    cd00204
    Location:34162
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:110206
    Ank_2; Ankyrin repeats (3 copies)
    pfam13920
    Location:372417
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]
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