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AMIGO1 adhesion molecule with Ig like domain 1 [ Homo sapiens (human) ]

Gene ID: 57463, updated on 17-May-2023

Summary

Official Symbol
AMIGO1provided by HGNC
Official Full Name
adhesion molecule with Ig like domain 1provided by HGNC
Primary source
HGNC:HGNC:20824
See related
Ensembl:ENSG00000181754 MIM:615689; AllianceGenome:HGNC:20824
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALI2; AMIGO; AMIGO-1
Summary
Predicted to enable potassium channel regulator activity. Predicted to be involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and nervous system development. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in dendrite and neuronal cell body membrane. Predicted to be integral component of membrane. Predicted to colocalize with voltage-gated potassium channel complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 9.3), adrenal (RPKM 6.7) and 24 other tissues See more
Orthologs
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Genomic context

See AMIGO1 in Genome Data Viewer
Location:
1p13.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (109504178..109509727, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (109536945..109542494, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110046800..110052349, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cytochrome b561 family member D1 Neighboring gene Sharpr-MPRA regulatory region 8825 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110042111-110042610 Neighboring gene uncharacterized LOC105378893 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110082007-110082508 Neighboring gene G protein-coupled receptor 61

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables potassium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in axonal fasciculation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in axonogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to L-glutamate IEA
Inferred from Electronic Annotation
more info
 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in myelination ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuronal cell body membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in pericellular basket IEA
Inferred from Electronic Annotation
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
amphoterin-induced protein 1
Names
alivin-2
amphoterin-induced gene and ORF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020703.4NP_065754.2  amphoterin-induced protein 1 precursor

    See identical proteins and their annotated locations for NP_065754.2

    Status: VALIDATED

    Source sequence(s)
    AK295678, AL355145, HY122839
    Consensus CDS
    CCDS30795.1
    UniProtKB/Swiss-Prot
    Q86WK6, Q9ULQ7
    Related
    ENSP00000358880.4, ENST00000369864.5
    Conserved Domains (3) summary
    smart00409
    Location:279358
    IG; Immunoglobulin
    COG4886
    Location:66242
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:6687
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    109504178..109509727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541812.3XP_011540114.1  amphoterin-induced protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011540114.1

    UniProtKB/Swiss-Prot
    Q86WK6, Q9ULQ7
    Related
    ENSP00000358878.1, ENST00000369862.1
    Conserved Domains (3) summary
    smart00409
    Location:279358
    IG; Immunoglobulin
    COG4886
    Location:66242
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:6687
    LRR_RI; leucine-rich repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    109536945..109542494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337816.1XP_054193791.1  amphoterin-induced protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9ULQ7