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AMIGO1 adhesion molecule with Ig like domain 1 [ Homo sapiens (human) ]

Gene ID: 57463, updated on 22-Aug-2020

Summary

Official Symbol
AMIGO1provided by HGNC
Official Full Name
adhesion molecule with Ig like domain 1provided by HGNC
Primary source
HGNC:HGNC:20824
See related
Ensembl:ENSG00000181754 MIM:615689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALI2; AMIGO; AMIGO-1
Expression
Ubiquitous expression in brain (RPKM 9.3), adrenal (RPKM 6.7) and 24 other tissues See more
Orthologs

Genomic context

See AMIGO1 in Genome Data Viewer
Location:
1p13.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (109504178..109509742, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110049446..110052336, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ataxin 7 like 2 Neighboring gene cytochrome b561 family member D1 Neighboring gene uncharacterized LOC105378893 Neighboring gene G protein-coupled receptor 61

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
New loci associated with kidney function and chronic kidney disease.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
potassium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
axonal fasciculation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
axonogenesis IEA
Inferred from Electronic Annotation
more info
 
brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to L-glutamate IEA
Inferred from Electronic Annotation
more info
 
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
myelination ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
pericellular basket IEA
Inferred from Electronic Annotation
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
amphoterin-induced protein 1
Names
alivin-2
amphoterin-induced gene and ORF

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020703.4NP_065754.2  amphoterin-induced protein 1 precursor

    See identical proteins and their annotated locations for NP_065754.2

    Status: VALIDATED

    Source sequence(s)
    AK295678, AL355145, HY122839
    Consensus CDS
    CCDS30795.1
    UniProtKB/Swiss-Prot
    Q86WK6
    Related
    ENSP00000358880.4, ENST00000369864.5
    Conserved Domains (3) summary
    smart00410
    Location:279358
    IG_like; Immunoglobulin like
    COG4886
    Location:66242
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:6687
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    109504178..109509742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541812.2XP_011540114.1  amphoterin-induced protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011540114.1

    UniProtKB/Swiss-Prot
    Q86WK6
    Related
    ENSP00000358878.1, ENST00000369862.1
    Conserved Domains (3) summary
    smart00410
    Location:279358
    IG_like; Immunoglobulin like
    COG4886
    Location:66242
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:6687
    LRR_RI; leucine-rich repeat [structural motif]
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