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PTH2R parathyroid hormone 2 receptor [ Homo sapiens (human) ]

Gene ID: 5746, updated on 7-Jun-2020

Summary

Official Symbol
PTH2Rprovided by HGNC
Official Full Name
parathyroid hormone 2 receptorprovided by HGNC
Primary source
HGNC:HGNC:9609
See related
Ensembl:ENSG00000144407 MIM:601469
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTHR2
Summary
The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Expression
Biased expression in bone marrow (RPKM 1.3), salivary gland (RPKM 0.8) and 10 other tissues See more
Orthologs

Genomic context

See PTH2R in Genome Data Viewer
Location:
2q34
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (208359692..208494506)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (209224569..209359231)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene IDH1 antisense RNA 1 Neighboring gene phosphoinositide kinase, FYVE-type zinc finger containing Neighboring gene myosin light chain 6B pseudogene 1 Neighboring gene ARPC1B pseudogene 1 Neighboring gene uncharacterized LOC105373855 Neighboring gene H3 histone pseudogene 9 Neighboring gene uncharacterized LOC101927960 Neighboring gene uncharacterized LOC105373857 Neighboring gene uncharacterized LOC105373856

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
NHGRI GWA Catalog
Genome-wide gene-environment interaction analysis for asbestos exposure in lung cancer susceptibility.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
parathyroid hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
parathyroid hormone 2 receptor
Names
PTH2 receptor
parathyroid hormone receptor 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309516.2NP_001296445.1  parathyroid hormone 2 receptor isoform 2

    See identical proteins and their annotated locations for NP_001296445.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon, resulting in the use of an in-frame downstream start site, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC012362, AC019185, AK294181, BC036811, DB536374
    Consensus CDS
    CCDS82565.1
    UniProtKB/Swiss-Prot
    P49190
    UniProtKB/TrEMBL
    B4DFN8
    Related
    ENSP00000482485.1, ENST00000617735.4
    Conserved Domains (1) summary
    pfam00002
    Location:30298
    7tm_2; 7 transmembrane receptor (Secretin family)
  2. NM_001371905.1NP_001358834.1  parathyroid hormone 2 receptor isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC012362, AC019185, KF495708
  3. NM_001371906.1NP_001358835.1  parathyroid hormone 2 receptor isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC012362, AC019185, KF495708
  4. NM_001371907.1NP_001358836.1  parathyroid hormone 2 receptor isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC012362, AC019185, KF495708
  5. NM_005048.4NP_005039.1  parathyroid hormone 2 receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_005039.1

    Status: REVIEWED

    Source sequence(s)
    AC012362, AC019185
    Consensus CDS
    CCDS2383.1
    UniProtKB/Swiss-Prot
    P49190
    Related
    ENSP00000272847.2, ENST00000272847.6
    Conserved Domains (2) summary
    smart00008
    Location:60125
    HormR; Domain present in hormone receptors
    cd15982
    Location:141430
    7tmB1_PTH2R; parathyroid hormone 2 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

RNA

  1. NR_163991.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC012362, AC019185, KF495708
  2. NR_163992.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC012362, AC019185, KF495708
  3. NR_163993.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC012362, AC019185, KF495708
  4. NR_163994.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC012362, AC019185, KF495708

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    208359692..208494506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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