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TENM2 teneurin transmembrane protein 2 [ Homo sapiens (human) ]

Gene ID: 57451, updated on 13-Mar-2020

Summary

Official Symbol
TENM2provided by HGNC
Official Full Name
teneurin transmembrane protein 2provided by HGNC
Primary source
HGNC:HGNC:29943
See related
Ensembl:ENSG00000145934 MIM:610119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ODZ2; TEN2; TNM2; ten-2; TEN-M2
Expression
Biased expression in heart (RPKM 7.7), brain (RPKM 2.7) and 6 other tissues See more
Orthologs

Genomic context

See TENM2 in Genome Data Viewer
Location:
5q34
Exon count:
36
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (166979066..168264159)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (166406083..167691162)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377706 Neighboring gene long intergenic non-protein coding RNA 1947 Neighboring gene uncharacterized LOC101927908 Neighboring gene uncharacterized LOC105377709 Neighboring gene uncharacterized LOC101927862 Neighboring gene microRNA 12125 Neighboring gene WW and C2 domain containing 1 Neighboring gene arginyl-tRNA synthetase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
NHGRI GWA Catalog
Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia.
NHGRI GWA Catalog
Genome-wide association studies and heritability estimates of body mass index related phenotypes in bangladeshi adults.
NHGRI GWA Catalog
Genome-wide association study of periodontal pathogen colonization.
NHGRI GWA Catalog
Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686A1568

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of filopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
PML body ISS
Inferred from Sequence or Structural Similarity
more info
 
cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
filopodium ISS
Inferred from Sequence or Structural Similarity
more info
 
growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
teneurin-2
Names
neurestin alpha
odd Oz/ten-m homolog 2
odz, odd Oz/ten-m homolog 2
protein Odd Oz/ten-m homolog 2
tenascin-M2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080428.3NP_001073897.2  teneurin-2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and has multiple difference in the central coding region compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB032953, AC093304, AK056053, AL137500, BF950845, BQ774782, BX648178, CR936703
    Consensus CDS
    CCDS83040.1
    UniProtKB/Swiss-Prot
    Q9NT68
    UniProtKB/TrEMBL
    F8VNQ3
    Related
    ENSP00000427874.1, ENST00000520394.5
    Conserved Domains (12) summary
    COG3209
    Location:14502243
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:439468
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:10461095
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:21522228
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:502650
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:14431481
    RHS_repeat; RHS Repeat
    pfam06484
    Location:16183
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:348370
    EGF_2; EGF-like domain
    pfam13715
    Location:700784
    CarbopepD_reg_2; CarboxypepD_reg-like domain
    pfam15636
    Location:24532528
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:10081331
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:523564
    DSL; Delta serrate ligand
  2. NM_001122679.2NP_001116151.1  teneurin-2 isoform 1

    See identical proteins and their annotated locations for NP_001116151.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC008464, AC008601, AC008607, AC008637, AC008642, AC008705, AC011369, AC026689, AC093304
    Conserved Domains (11) summary
    COG3209
    Location:16802473
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:671700
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:12311270
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:23822458
    Rhs_assc_core; RHS repeat-associated core domain
    pfam05593
    Location:16731711
    RHS_repeat; RHS Repeat
    pfam06484
    Location:10374
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:580602
    EGF_2; EGF-like domain
    pfam13715
    Location:9231007
    CarbopepD_reg_2; CarboxypepD_reg-like domain
    pfam15636
    Location:26832758
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:12311561
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:755796
    DSL; Delta serrate ligand
  3. NM_001368145.1NP_001355074.1  teneurin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008464, AC008634, AC008637, AC008705, AC011369, AC026689, AC093304
  4. NM_001368146.1NP_001355075.1  teneurin-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC008464, AC008634, AC008637, AC008705, AC011369, AC026689, AC093304

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    166979066..168264159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009660.1XP_016865149.1  teneurin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q9NT68
    Related
    ENSP00000429430.1, ENST00000518659.5
    Conserved Domains (12) summary
    COG3209
    Location:16892482
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:671700
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:12401279
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:23912467
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:734882
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:16821720
    RHS_repeat; RHS Repeat
    pfam06484
    Location:10374
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:580602
    EGF_2; EGF-like domain
    pfam13715
    Location:9321016
    CarbopepD_reg_2; CarboxypepD_reg-like domain
    pfam15636
    Location:26922767
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:12401570
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:755796
    DSL; Delta serrate ligand
  2. XM_017009661.1XP_016865150.1  teneurin-2 isoform X2

  3. XM_006714897.2XP_006714960.1  teneurin-2 isoform X4

    Conserved Domains (11) summary
    COG3209
    Location:16732466
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:671700
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:12691318
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:23752451
    Rhs_assc_core; RHS repeat-associated core domain
    pfam05593
    Location:16661704
    RHS_repeat; RHS Repeat
    pfam06484
    Location:10374
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:580602
    EGF_2; EGF-like domain
    pfam13715
    Location:9231007
    CarbopepD_reg_2; CarboxypepD_reg-like domain
    pfam15636
    Location:26762751
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:12311554
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:755796
    DSL; Delta serrate ligand
  4. XM_011534604.2XP_011532906.1  teneurin-2 isoform X6

    Conserved Domains (11) summary
    COG3209
    Location:16182411
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:671700
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:11691208
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:23202396
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:640811
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:16111649
    RHS_repeat; RHS Repeat
    pfam06484
    Location:10374
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:576602
    EGF_2; EGF-like domain
    pfam13715
    Location:861945
    CarbopepD_reg_2; CarboxypepD_reg-like domain
    pfam15636
    Location:26212696
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:11691499
    NHL; NHL repeat unit of beta-propeller proteins
  5. XM_005265950.2XP_005266007.1  teneurin-2 isoform X3

    See identical proteins and their annotated locations for XP_005266007.1

    Conserved Domains (11) summary
    COG3209
    Location:16802473
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:671700
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:12311270
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:23822458
    Rhs_assc_core; RHS repeat-associated core domain
    pfam05593
    Location:16731711
    RHS_repeat; RHS Repeat
    pfam06484
    Location:10374
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:580602
    EGF_2; EGF-like domain
    pfam13715
    Location:9231007
    CarbopepD_reg_2; CarboxypepD_reg-like domain
    pfam15636
    Location:26832758
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:12311561
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:755796
    DSL; Delta serrate ligand
  6. XM_017009662.1XP_016865151.1  teneurin-2 isoform X5

  7. XM_017009665.1XP_016865154.1  teneurin-2 isoform X9

  8. XM_017009669.1XP_016865158.1  teneurin-2 isoform X12

  9. XM_017009663.2XP_016865152.1  teneurin-2 isoform X7

  10. XM_017009664.1XP_016865153.1  teneurin-2 isoform X8

    UniProtKB/TrEMBL
    G3V106
    Related
    ENSP00000428964.1, ENST00000519204.5
    Conserved Domains (12) summary
    COG3209
    Location:15682361
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:550579
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:11191158
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:22702346
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:613761
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:15611599
    RHS_repeat; RHS Repeat
    pfam06484
    Location:44253
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:459481
    EGF_2; EGF-like domain
    pfam13715
    Location:811895
    CarbopepD_reg_2; CarboxypepD_reg-like domain
    pfam15636
    Location:25712646
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:11191449
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:634675
    DSL; Delta serrate ligand
  11. XM_017009668.1XP_016865157.1  teneurin-2 isoform X12

  12. XM_005265952.2XP_005266009.1  teneurin-2 isoform X13

    Conserved Domains (11) summary
    COG3209
    Location:12932086
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:275304
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:844883
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:19952071
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:338486
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:12861324
    RHS_repeat; RHS Repeat
    pfam07974
    Location:184206
    EGF_2; EGF-like domain
    pfam13715
    Location:536620
    CarbopepD_reg_2; CarboxypepD_reg-like domain
    pfam15636
    Location:22962371
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:8441174
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:359400
    DSL; Delta serrate ligand
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