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TENM2 teneurin transmembrane protein 2 [ Homo sapiens (human) ]

Gene ID: 57451, updated on 29-Mar-2023

Summary

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Official Symbol
TENM2provided by HGNC
Official Full Name
teneurin transmembrane protein 2provided by HGNC
Primary source
HGNC:HGNC:29943
See related
Ensembl:ENSG00000145934 MIM:610119; AllianceGenome:HGNC:29943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ODZ2; TEN2; TNM2; ten-2; TEN-M2
Summary
Enables cell adhesion molecule binding activity and signaling receptor binding activity. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and retrograde trans-synaptic signaling by trans-synaptic protein complex. Located in cell-cell junction and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart (RPKM 7.7), brain (RPKM 2.7) and 6 other tissues See more
Orthologs
mouse all
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Genomic context

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See TENM2 in Genome Data Viewer
Location:
5q34
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (166979029..168264157)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (167513669..168798988)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (166406034..167691162)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1947 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:166405091-166405592 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:166405593-166406092 Neighboring gene uncharacterized LOC101927908 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:166721659-166722858 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:166724659-166725364 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:166730399-166730914 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:166732502-166733336 Neighboring gene uncharacterized LOC124901126 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:167000055-167000680 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:167000681-167001306 Neighboring gene uncharacterized LOC124901127 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:167125182-167125888 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:167126594-167127299 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:167286415-167286982 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:167342965-167344164 Neighboring gene uncharacterized LOC105377709 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:167364582-167365781 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:167372775-167373276 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:167420767-167421268 Neighboring gene uncharacterized LOC124900211 Neighboring gene Sharpr-MPRA regulatory region 1255 Neighboring gene NANOG hESC enhancer GRCh37_chr5:167474734-167475491 Neighboring gene NANOG hESC enhancer GRCh37_chr5:167537301-167537860 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:167551431-167552630 Neighboring gene uncharacterized LOC124901128 Neighboring gene microRNA 12125 Neighboring gene TENM2 antisense RNA 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:167741294-167741817 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:167754608-167755524 Neighboring gene WW and C2 domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones. Vysokov NV, et al. Elife, 2018 Nov 20. PMID 30457553, Free PMC Article
  2. Teneurin-2 (TENM2) deficiency induces UCP1 expression in differentiating human fat cells. Tews D, et al. Mol Cell Endocrinol, 2017 Mar 5. PMID 28088466
  3. Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities. Silva JP, et al. Proc Natl Acad Sci U S A, 2011 Jul 19. PMID 21724987, Free PMC Article
  4. Mucosa-associated lymphoid tissue lymphoma: novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3. Vinatzer U, et al. Clin Cancer Res, 2008 Oct 15. PMID 18927281
  5. The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription. Bagutti C, et al. J Cell Sci, 2003 Jul 15. PMID 12783990

See all (23) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings reveal a novel mechanism of axonal pathfinding, whereby latrophilin-1 and Lasso mediate both short-range interaction that supports synaptogenesis, and long-range signaling that induces axonal attraction.
    Title: Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones.
  2. TENM2 knockdown induces both UCP1 mRNA and protein expression upon adipogenic differentiation without affecting mitochondrial mass.
    Title: Teneurin-2 (TENM2) deficiency induces UCP1 expression in differentiating human fat cells.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  4. Gene rearrangements of ODZ2 is associated with mucosa-associated lymphoid tissue lymphoma.
    Title: Mucosa-associated lymphoid tissue lymphoma: novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3.
  5. intracellular domain of teneurin-2 has a nuclear function and role in repressing zic-1-mediated transcription
    Title: The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
EBI GWAS Catalog
Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia.
EBI GWAS Catalog
Genome-wide association studies and heritability estimates of body mass index related phenotypes in bangladeshi adults.
EBI GWAS Catalog
Genome-wide association study of periodontal pathogen colonization.
EBI GWAS Catalog
Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686A1568

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron development IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of filopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in PML body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell junction ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in filopodium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in growth cone ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
teneurin-2
Names
neurestin alpha
odd Oz/ten-m homolog 2
odz, odd Oz/ten-m homolog 2
protein Odd Oz/ten-m homolog 2
tenascin-M2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080428.3 → NP_001073897.2  teneurin-2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and has multiple difference in the central coding region compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB032953, AC093304, AK056053, AL137500, BF950845, BQ774782, BX648178, CR936703
    Consensus CDS
    CCDS83040.1
    UniProtKB/Swiss-Prot
    Q9NT68
    UniProtKB/TrEMBL
    F8VNQ3
    Related
    ENSP00000427874.1, ENST00000520394.5
    Conserved Domains (12) summary
    COG3209
    Location:1450 → 2243
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:439 → 468
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:1046 → 1095
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2152 → 2228
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:502 → 650
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:1443 → 1481
    RHS_repeat; RHS Repeat
    pfam06484
    Location:16 → 183
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:348 → 370
    EGF_2; EGF-like domain
    pfam13715
    Location:700 → 784
    CarbopepD_reg_2; CarboxypepD_reg-like domain
    pfam15636
    Location:2453 → 2528
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1008 → 1331
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:523 → 564
    DSL; Delta serrate ligand

  2. NM_001122679.2 → NP_001116151.1  teneurin-2 isoform 1

    See identical proteins and their annotated locations for NP_001116151.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC008464, AC008601, AC008607, AC008637, AC008642, AC008705, AC011369, AC026689, AC093304
    Conserved Domains (10) summary
    COG3209
    Location:1946 → 2432
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:798 → 831
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:1231 → 1270
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2382 → 2458
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1231 → 1561
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1673 → 1709
    RHS_repeat; RHS Repeat
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2681 → 2758
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    pfam19232
    Location:575 → 734
    DUF5885; Family of unknown function (DUF5885)
    cl19567
    Location:755 → 796
    DSL; Delta serrate ligand

  3. NM_001368145.1 → NP_001355074.1  teneurin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008464, AC008634, AC008637, AC008705, AC011369, AC026689, AC093304

  4. NM_001368146.1 → NP_001355075.1  teneurin-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC008464, AC008634, AC008637, AC008705, AC011369, AC026689, AC093304
    Consensus CDS
    CCDS93819.1
    UniProtKB/TrEMBL
    A0A8Q3SI97
    Related
    ENSP00000512239.1, ENST00000695886.1

  5. NM_001395460.1 → NP_001382389.1  teneurin-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC008464, AC008601, AC008607, AC008637, AC008642, AC008705, AC011369, AC026689, AC026729, AC093304
    Consensus CDS
    CCDS93818.1
    UniProtKB/Swiss-Prot
    Q9ULU2
    Related
    ENSP00000429430.1, ENST00000518659.6
    Conserved Domains (8) summary
    COG3209
    Location:1955 → 2441
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1240 → 1279
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2391 → 2467
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1240 → 1570
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1682 → 1718
    RHS_repeat; RHS Repeat
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2690 → 2767
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:570 → 885
    exchanger_TraA; outer membrane exchange protein TraA

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    166979029..168264157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417418.1 → XP_047273374.1  teneurin-2 isoform X3

  2. XM_017009661.2 → XP_016865150.1  teneurin-2 isoform X1

  3. XM_005265950.3 → XP_005266007.1  teneurin-2 isoform X2

    See identical proteins and their annotated locations for XP_005266007.1

    Conserved Domains (10) summary
    COG3209
    Location:1946 → 2432
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:798 → 831
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:1231 → 1270
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2382 → 2458
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1231 → 1561
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1673 → 1709
    RHS_repeat; RHS Repeat
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2681 → 2758
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    pfam19232
    Location:575 → 734
    DUF5885; Family of unknown function (DUF5885)
    cl19567
    Location:755 → 796
    DSL; Delta serrate ligand

  4. XM_011534604.3 → XP_011532906.1  teneurin-2 isoform X5

    Conserved Domains (11) summary
    COG3209
    Location:1618 → 2411
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:671 → 700
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:1169 → 1208
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2320 → 2396
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:640 → 811
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:1611 → 1649
    RHS_repeat; RHS Repeat
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:576 → 602
    EGF_2; EGF-like domain
    pfam13715
    Location:861 → 945
    CarbopepD_reg_2; CarboxypepD_reg-like domain
    pfam15636
    Location:2621 → 2696
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1169 → 1499
    NHL; NHL repeat unit of beta-propeller proteins

  5. XM_047417420.1 → XP_047273376.1  teneurin-2 isoform X8

  6. XM_017009662.2 → XP_016865151.1  teneurin-2 isoform X4

  7. XM_047417419.1 → XP_047273375.1  teneurin-2 isoform X7

  8. XM_017009665.2 → XP_016865154.1  teneurin-2 isoform X16

  9. XM_047417427.1 → XP_047273383.1  teneurin-2 isoform X17

  10. XM_017009669.2 → XP_016865158.1  teneurin-2 isoform X20

    UniProtKB/TrEMBL
    A0A8Q3SIA3

  11. XM_017009663.3 → XP_016865152.1  teneurin-2 isoform X6

  12. XM_047417421.1 → XP_047273377.1  teneurin-2 isoform X9

  13. XM_047417422.1 → XP_047273378.1  teneurin-2 isoform X10

  14. XM_047417423.1 → XP_047273379.1  teneurin-2 isoform X11

  15. XM_017009664.2 → XP_016865153.1  teneurin-2 isoform X12

    UniProtKB/TrEMBL
    G3V106
    Related
    ENSP00000428964.1, ENST00000519204.5
    Conserved Domains (12) summary
    COG3209
    Location:1568 → 2361
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:550 → 579
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:1119 → 1158
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2270 → 2346
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:613 → 761
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:1561 → 1599
    RHS_repeat; RHS Repeat
    pfam06484
    Location:44 → 253
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:459 → 481
    EGF_2; EGF-like domain
    pfam13715
    Location:811 → 895
    CarbopepD_reg_2; CarboxypepD_reg-like domain
    pfam15636
    Location:2571 → 2646
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1119 → 1449
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:634 → 675
    DSL; Delta serrate ligand

  16. XM_047417424.1 → XP_047273380.1  teneurin-2 isoform X13

  17. XM_047417425.1 → XP_047273381.1  teneurin-2 isoform X14

  18. XM_047417426.1 → XP_047273382.1  teneurin-2 isoform X15

  19. XM_047417432.1 → XP_047273388.1  teneurin-2 isoform X21

  20. XM_047417430.1 → XP_047273386.1  teneurin-2 isoform X19

  21. XM_017009668.2 → XP_016865157.1  teneurin-2 isoform X20

    UniProtKB/TrEMBL
    A0A8Q3SIA3
    Related
    ENSP00000512289.1, ENST00000695961.1

  22. XM_047417431.1 → XP_047273387.1  teneurin-2 isoform X19

  23. XM_047417428.1 → XP_047273384.1  teneurin-2 isoform X18

  24. XM_047417429.1 → XP_047273385.1  teneurin-2 isoform X19

  25. XM_047417433.1 → XP_047273389.1  teneurin-2 isoform X22

  26. XM_005265952.3 → XP_005266009.1  teneurin-2 isoform X23

    Related
    ENSP00000512290.1, ENST00000695962.1
    Conserved Domains (11) summary
    COG3209
    Location:1293 → 2086
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:275 → 304
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:844 → 883
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:1995 → 2071
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:338 → 486
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:1286 → 1324
    RHS_repeat; RHS Repeat
    pfam07974
    Location:184 → 206
    EGF_2; EGF-like domain
    pfam13715
    Location:536 → 620
    CarbopepD_reg_2; CarboxypepD_reg-like domain
    pfam15636
    Location:2296 → 2371
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:844 → 1174
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:359 → 400
    DSL; Delta serrate ligand

  27. XM_047417434.1 → XP_047273390.1  teneurin-2 isoform X24

  28. XM_047417435.1 → XP_047273391.1  teneurin-2 isoform X25

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    167513669..168798988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352965.1 → XP_054208940.1  teneurin-2 isoform X3

  2. XM_054352963.1 → XP_054208938.1  teneurin-2 isoform X1

  3. XM_054352964.1 → XP_054208939.1  teneurin-2 isoform X2

  4. XM_054352971.1 → XP_054208946.1  teneurin-2 isoform X5

  5. XM_054352973.1 → XP_054208948.1  teneurin-2 isoform X8

  6. XM_054352970.1 → XP_054208945.1  teneurin-2 isoform X4

  7. XM_054352972.1 → XP_054208947.1  teneurin-2 isoform X7

  8. XM_054352978.1 → XP_054208953.1  teneurin-2 isoform X16

  9. XM_054352979.1 → XP_054208954.1  teneurin-2 isoform X17

  10. XM_054352985.1 → XP_054208960.1  teneurin-2 isoform X20

  11. XM_054352966.1 → XP_054208941.1  teneurin-2 isoform X26

  12. XM_054352967.1 → XP_054208942.1  teneurin-2 isoform X27

  13. XM_054352968.1 → XP_054208943.1  teneurin-2 isoform X28

  14. XM_054352969.1 → XP_054208944.1  teneurin-2 isoform X29

  15. XM_054352974.1 → XP_054208949.1  teneurin-2 isoform X12

  16. XM_054352975.1 → XP_054208950.1  teneurin-2 isoform X13

  17. XM_054352976.1 → XP_054208951.1  teneurin-2 isoform X14

  18. XM_054352977.1 → XP_054208952.1  teneurin-2 isoform X15

  19. XM_054352986.1 → XP_054208961.1  teneurin-2 isoform X21

  20. XM_054352982.1 → XP_054208957.1  teneurin-2 isoform X19

  21. XM_054352983.1 → XP_054208958.1  teneurin-2 isoform X19

  22. XM_054352984.1 → XP_054208959.1  teneurin-2 isoform X20

  23. XM_054352980.1 → XP_054208955.1  teneurin-2 isoform X18

  24. XM_054352981.1 → XP_054208956.1  teneurin-2 isoform X19

  25. XM_054352987.1 → XP_054208962.1  teneurin-2 isoform X22

  26. XM_054352988.1 → XP_054208963.1  teneurin-2 isoform X23

  27. XM_054352989.1 → XP_054208964.1  teneurin-2 isoform X24

  28. XM_054352990.1 → XP_054208965.1  teneurin-2 isoform X25

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NT68.3 GenPept UniProtKB/Swiss-Prot:Q9NT68

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