MIR520C microRNA 520c [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR520Cprovided by HGNC
Official Full Name: microRNA 520cprovided by HGNC
Primary source: HGNC:HGNC:32108
See related: Ensembl:ENSG00000207738 MIM:615908; miRBase:MI0003158; AllianceGenome:HGNC:32108
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN520C
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 19q13.42

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (53707453..53707539)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (56786957..56787043)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (54210707..54210793)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of lncRNA HOXA-AS2 promotes the progression of oral squamous cell carcinoma by mediating SNX5 expression.
Title: Overexpression of lncRNA HOXA-AS2 promotes the progression of oral squamous cell carcinoma by mediating SNX5 expression.
Deciphering miR-520c-3p as a probable target for immunometabolism in non-small cell lung cancer using systems biology approach.
Title: Deciphering miR-520c-3p as a probable target for immunometabolism in non-small cell lung cancer using systems biology approach.
Melatonin regulates trophoblast pyroptosis, invasion and migration in preeclampsia by inhibiting HtrA1 transcription through the microRNA-520c-3p/SETD7 axis.
Title: Melatonin regulates trophoblast pyroptosis, invasion and migration in preeclampsia by inhibiting HtrA1 transcription through the microRNA-520c-3p/SETD7 axis.
MicroRNA-520c-3p targeting of RelA/p65 suppresses atherosclerotic plaque formation.
Title: MicroRNA-520c-3p targeting of RelA/p65 suppresses atherosclerotic plaque formation.
MicroRNA-520c-3p suppresses vascular endothelium dysfunction by targeting RELA and regulating the AKT and NF-kappaB signaling pathways.
Title: MicroRNA-520c-3p suppresses vascular endothelium dysfunction by targeting RELA and regulating the AKT and NF-κB signaling pathways.
MicroRNA-520c-3p Modulates Doxorubicin-Chemosensitivity in HepG2 Cells.
Title: MicroRNA-520c-3p Modulates Doxorubicin-Chemosensitivity in HepG2 Cells.
MiR-520c-3p alleviates LPS-induced A549 cell and mice lung injury via targeting NLRC5.
Title: MiR-520c-3p alleviates LPS-induced A549 cell and mice lung injury via targeting NLRC5.
LncRNA TPTE2P1 promotes the proliferation of thyroid carcinoma by inhibiting miR-520c-3p.
Title: LncRNA TPTE2P1 promotes the proliferation of thyroid carcinoma by inhibiting miR-520c-3p.
as a potent tumor suppressor, miR-520c-3p shows a significantly lower expression level in lung adenocarcinoma.
Title: MicroRNA-520c-3p functions as a novel tumor suppressor in lung adenocarcinoma.
Collectively, miR-520c-3p could potentially inhibit NLRP3 inflammasome activation and inflammatory cascade in preeclampsia (PE) by downregulating NLRP3, highlighting the potential of miR-520c-3p as a therapeutic target for PE treatment.
Title: microRNA-520c-3p suppresses NLRP3 inflammasome activation and inflammatory cascade in preeclampsia by downregulating NLRP3.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA base-pairing translational repressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in miRNA-mediated gene silencing by inhibition of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated gene silencing by mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of amyloid precursor protein biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of cellular biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of glycoprotein biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-8 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of cell adhesion molecule production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.