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TMIGD3 transmembrane and immunoglobulin domain containing 3 [ Homo sapiens (human) ]

Gene ID: 57413, updated on 11-Jun-2021

Summary

Official Symbol
TMIGD3provided by HGNC
Official Full Name
transmembrane and immunoglobulin domain containing 3provided by HGNC
Primary source
HGNC:HGNC:51375
See related
Ensembl:ENSG00000121933
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AD026
Summary
This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 5' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:140), thus resulting in a fusion product. [provided by RefSeq, Nov 2014]
Expression
Biased expression in testis (RPKM 14.5), adrenal (RPKM 4.5) and 10 other tissues See more
Orthologs
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Genomic context

See TMIGD3 in Genome Data Viewer
Location:
1p13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (111483348..111563962, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (112025970..112106584, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene WD repeat domain 77 Neighboring gene ATP synthase peripheral stalk-membrane subunit b Neighboring gene chromosome 1 open reading frame 162 Neighboring gene RNA, U6 small nuclear 792, pseudogene Neighboring gene adenosine A3 receptor Neighboring gene RAP1A, member of RAS oncogene family Neighboring gene long intergenic non-protein coding RNA 1160 Neighboring gene uncharacterized LOC107985184 Neighboring gene Sharpr-MPRA regulatory region 155

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General protein information

Preferred Names
transmembrane and immunoglobulin domain containing 3
Names
AD026 protein (AD026)
transmembrane domain-containing protein TMIGD3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081976.3NP_001075445.1  transmembrane and immunoglobulin domain containing 3 isoform 3

    See identical proteins and their annotated locations for NP_001075445.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, resulting in an alternate 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1, and it does not share any similarity with the adenosine A3 receptor.
    Source sequence(s)
    BC041707, HY011888
    Consensus CDS
    CCDS41369.1
    UniProtKB/Swiss-Prot
    P0DMS9
    Related
    ENSP00000358731.4, ENST00000369717.8
    Conserved Domains (1) summary
    cl11960
    Location:88156
    Ig; Immunoglobulin domain
  2. NM_001302680.2NP_001289609.1  transmembrane and immunoglobulin domain containing 3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon, lacks an internal exon and uses an alternate splice site in another exon, thus resulting in an alternate 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1, and it does not share any similarity with the adenosine A3 receptor.
    Source sequence(s)
    BC041707, BI828255, HY011888
    UniProtKB/Swiss-Prot
    P0DMS9
    Related
    ENSP00000398770.1, ENST00000443498.5
    Conserved Domains (1) summary
    cl11960
    Location:5168
    Ig; Immunoglobulin domain
  3. NM_020683.7NP_065734.5  transmembrane and immunoglobulin domain containing 3 isoform 1

    See identical proteins and their annotated locations for NP_065734.5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). It shares its 5' terminal exon with the adenosine A3 receptor gene (GeneID:140), and it thus produces a fusion protein that includes the adenosine A3 receptor protein N-terminus fused to the product of this gene (GeneID:57413).
    Source sequence(s)
    AL390195, AY358644
    Consensus CDS
    CCDS838.1
    UniProtKB/Swiss-Prot
    P0DMS9
    Related
    ENSP00000358730.4, ENST00000369716.9
    Conserved Domains (2) summary
    cl11960
    Location:169237
    Ig; Immunoglobulin domain
    cl21561
    Location:21109
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    111483348..111563962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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