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Mogs mannosyl-oligosaccharide glucosidase [ Mus musculus (house mouse) ]

Gene ID: 57377, updated on 14-May-2024

Summary

Official Symbol
Mogsprovided by MGI
Official Full Name
mannosyl-oligosaccharide glucosidaseprovided by MGI
Primary source
MGI:MGI:1929872
See related
Ensembl:ENSMUSG00000030036 AllianceGenome:MGI:1929872
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gcs1; 1810017N02Rik
Summary
Predicted to enable Glc3Man9GlcNAc2 oligosaccharide glucosidase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIb. Orthologous to human MOGS (mannosyl-oligosaccharide glucosidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 54.3), ovary adult (RPKM 52.3) and 28 other tissues See more
Orthologs
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Genomic context

See Mogs in Genome Data Viewer
Location:
6 C3; 6 35.94 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83092477..83095883)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83115506..83118902)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene microRNA 3470a Neighboring gene coiled-coil domain containing 142 Neighboring gene mitochondrial ribosomal protein L53 Neighboring gene STARR-positive B cell enhancer ABC_E6446 Neighboring gene STARR-positive B cell enhancer ABC_E344 Neighboring gene WW domain binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E9669 Neighboring gene INO80 complex subunit B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in oligosaccharide metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mannosyl-oligosaccharide glucosidase
Names
ER glu I
endoplasmic reticulum alpha-glucosidase I
glucosidase 1
glycoprotein-processing glucosidase I
NP_065644.2
XP_006506487.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020619.3NP_065644.2  mannosyl-oligosaccharide glucosidase

    See identical proteins and their annotated locations for NP_065644.2

    Status: VALIDATED

    Source sequence(s)
    BC051949, BY625811
    Consensus CDS
    CCDS20273.1
    UniProtKB/Swiss-Prot
    Q80UM7, Q9Z2W5
    UniProtKB/TrEMBL
    Q3U026, Q3UME9
    Related
    ENSMUSP00000032114.8, ENSMUST00000032114.8
    Conserved Domains (2) summary
    pfam03200
    Location:349832
    Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain
    pfam16923
    Location:92243
    Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    83092477..83095883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506424.3XP_006506487.1  mannosyl-oligosaccharide glucosidase isoform X1

    Conserved Domains (1) summary
    pfam03200
    Location:75558
    Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain